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The Injection Molding of Biodegradable Polydioxanone—A Study of the Dependence of the Structural and Mechanical Properties on Thermal Processing Conditions

Recent years have observed a significant increase in the use of degradable materials in medicine due to their minimal impact on the patient and broad range of applicability. The biodegradable polymer Polydioxanone (PDO) provides a good example of the use of such one polymer that can represent the af...

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Detalles Bibliográficos
Autores principales: Erben, Jakub, Blatonova, Katerina, Kalous, Tomas, Capek, Lukas, Behalek, Lubos, Boruvka, Martin, Chvojka, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781196/
https://www.ncbi.nlm.nih.gov/pubmed/36559895
http://dx.doi.org/10.3390/polym14245528
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author Erben, Jakub
Blatonova, Katerina
Kalous, Tomas
Capek, Lukas
Behalek, Lubos
Boruvka, Martin
Chvojka, Jiri
author_facet Erben, Jakub
Blatonova, Katerina
Kalous, Tomas
Capek, Lukas
Behalek, Lubos
Boruvka, Martin
Chvojka, Jiri
author_sort Erben, Jakub
collection PubMed
description Recent years have observed a significant increase in the use of degradable materials in medicine due to their minimal impact on the patient and broad range of applicability. The biodegradable polymer Polydioxanone (PDO) provides a good example of the use of such one polymer that can represent the aforementioned medical materials in the field of medicine, due to its high level of biocompatibility and interesting mechanical properties. PDO is used to produce absorbable medical devices such as sutures and stents, and is also suitable for the fabrication of certain orthopedic implants. Polydioxanone can be processed using the injection molding method due to its thermoplastic nature; this method allows for the precise and easily-controllable production of medical materials without the need for toxic additives. A number of small commercial polymer implants have recently been introduced onto the market based on this processing method. It is important to note that, to date, no relevant information on the molding of PDO is available either for the scientific or the general public, and no study has been published that describes the potential of the injection molding of PDO. Hence, we present our research on the basic technological and material parameters that allow for the processing of PDO using the laboratory microinjection molding method. In addition to determining the basic parameters of the process, the research also focused on the study of the structural and mechanical properties of samples based on the thermal conditions during processing. A technological frame work was successfully determined for the processing of PDO via the microinjection molding approach that allows for the production of samples with the required homogeneity, shape stability and surface quality in a laboratory scale. The research revealed that PDO is a polymer with a major share of crystalline phases, and that it is sensitive to the annealing temperature profile in the mold, which has the potential to impact the final crystalline structure, the fracture morphology and the mechanical properties.
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spelling pubmed-97811962022-12-24 The Injection Molding of Biodegradable Polydioxanone—A Study of the Dependence of the Structural and Mechanical Properties on Thermal Processing Conditions Erben, Jakub Blatonova, Katerina Kalous, Tomas Capek, Lukas Behalek, Lubos Boruvka, Martin Chvojka, Jiri Polymers (Basel) Article Recent years have observed a significant increase in the use of degradable materials in medicine due to their minimal impact on the patient and broad range of applicability. The biodegradable polymer Polydioxanone (PDO) provides a good example of the use of such one polymer that can represent the aforementioned medical materials in the field of medicine, due to its high level of biocompatibility and interesting mechanical properties. PDO is used to produce absorbable medical devices such as sutures and stents, and is also suitable for the fabrication of certain orthopedic implants. Polydioxanone can be processed using the injection molding method due to its thermoplastic nature; this method allows for the precise and easily-controllable production of medical materials without the need for toxic additives. A number of small commercial polymer implants have recently been introduced onto the market based on this processing method. It is important to note that, to date, no relevant information on the molding of PDO is available either for the scientific or the general public, and no study has been published that describes the potential of the injection molding of PDO. Hence, we present our research on the basic technological and material parameters that allow for the processing of PDO using the laboratory microinjection molding method. In addition to determining the basic parameters of the process, the research also focused on the study of the structural and mechanical properties of samples based on the thermal conditions during processing. A technological frame work was successfully determined for the processing of PDO via the microinjection molding approach that allows for the production of samples with the required homogeneity, shape stability and surface quality in a laboratory scale. The research revealed that PDO is a polymer with a major share of crystalline phases, and that it is sensitive to the annealing temperature profile in the mold, which has the potential to impact the final crystalline structure, the fracture morphology and the mechanical properties. MDPI 2022-12-16 /pmc/articles/PMC9781196/ /pubmed/36559895 http://dx.doi.org/10.3390/polym14245528 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Erben, Jakub
Blatonova, Katerina
Kalous, Tomas
Capek, Lukas
Behalek, Lubos
Boruvka, Martin
Chvojka, Jiri
The Injection Molding of Biodegradable Polydioxanone—A Study of the Dependence of the Structural and Mechanical Properties on Thermal Processing Conditions
title The Injection Molding of Biodegradable Polydioxanone—A Study of the Dependence of the Structural and Mechanical Properties on Thermal Processing Conditions
title_full The Injection Molding of Biodegradable Polydioxanone—A Study of the Dependence of the Structural and Mechanical Properties on Thermal Processing Conditions
title_fullStr The Injection Molding of Biodegradable Polydioxanone—A Study of the Dependence of the Structural and Mechanical Properties on Thermal Processing Conditions
title_full_unstemmed The Injection Molding of Biodegradable Polydioxanone—A Study of the Dependence of the Structural and Mechanical Properties on Thermal Processing Conditions
title_short The Injection Molding of Biodegradable Polydioxanone—A Study of the Dependence of the Structural and Mechanical Properties on Thermal Processing Conditions
title_sort injection molding of biodegradable polydioxanone—a study of the dependence of the structural and mechanical properties on thermal processing conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781196/
https://www.ncbi.nlm.nih.gov/pubmed/36559895
http://dx.doi.org/10.3390/polym14245528
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