A Single Amino Acid Replacement Boosts the Analgesic Activity of α-Conotoxin AuIB through the Inhibition of the GABA(B)R-Coupled N-Type Calcium Channel

α-conotoxin AuIB is the only one of the 4/6 type α-conotoxins (α-CTxs) that inhibits the γ-aminobutyric acid receptor B (GABA(B)R)-coupled N-type calcium channel (Ca(V)2.2). To improve its inhibitory activity, a series of variants were synthesized and evaluated according to the structure–activity re...

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Detalles Bibliográficos
Autores principales: Wei, Yuanmei, Zhang, Min, Yu, Shuo, Huang, Qiuyuan, Chen, Rongfang, Xu, Shujing, Huang, Yue, Yu, Yunzhou, Liao, Ming, Dai, Qiuyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781320/
https://www.ncbi.nlm.nih.gov/pubmed/36547897
http://dx.doi.org/10.3390/md20120750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781320/
https://www.ncbi.nlm.nih.gov/pubmed/36547897
http://dx.doi.org/10.3390/md20120750

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