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Predictive Factors for Poor Outcome following Chemonucleolysis with Condoliase in Lumbar Disc Herniation
Background and Objectives: Condoliase, a chondroitin sulfate ABC endolyase, is a novel and minimally invasive chemonucleolytic drug for lumbar disc herniation. Despite the growing number of treatments for lumbar disc herniation, the predicting factors for poor outcomes following treatment remain unc...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781337/ https://www.ncbi.nlm.nih.gov/pubmed/36557070 http://dx.doi.org/10.3390/medicina58121868 |
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author | Takeuchi, Shu Hanakita, Junya Takahashi, Toshiyuki Inoue, Tomoo Minami, Manabu Suda, Izumi Nakamura, Sho Kanematsu, Ryo |
author_facet | Takeuchi, Shu Hanakita, Junya Takahashi, Toshiyuki Inoue, Tomoo Minami, Manabu Suda, Izumi Nakamura, Sho Kanematsu, Ryo |
author_sort | Takeuchi, Shu |
collection | PubMed |
description | Background and Objectives: Condoliase, a chondroitin sulfate ABC endolyase, is a novel and minimally invasive chemonucleolytic drug for lumbar disc herniation. Despite the growing number of treatments for lumbar disc herniation, the predicting factors for poor outcomes following treatment remain unclear. The aim of this study was to determine the predictive factors for unsuccessful clinical outcome following condoliase therapy. Material and Methods: We performed a retrospective single-center analysis of 101 patients who underwent chemonucleolysis with condoliase from January 2019 to December 2021. Patients were divided into good outcome (i.e., favorable outcome) and poor outcome (i.e., requiring additional surgical treatment) groups. Patient demographics and imaging findings were collected. Clinical outcomes were evaluated using the numerical rating scale and Japanese Orthopaedic Association scores at baseline and at 1- and 3-month follow-up. Pretreatment indicators for additional surgery were compared between the 2 groups. Results: There was a significant difference in baseline leg numbness between the good outcome and poor outcome groups (6.27 ± 1.90 vs. 4.42 ± 2.90, respectively; p = 0.033). Of the 101 included patients, 32 received a preoperative computed tomography scan. In those patients, the presence of calcification or ossification in disc hernia occurred more often in the poor outcome group (61.5% vs. 5.3%, respectively; p < 0.001; odds ratio = 22.242; p = 0.014). Receiver-operating characteristics curve analysis for accompanying calcification or ossification showed an area under the curve of 0.858 (95% confidence interval, 0.715–1.000; p = 0.001). Conclusions: Calcified or ossified disc herniation may be useful predictors of unsuccessful treatment in patients with condoliase administration. |
format | Online Article Text |
id | pubmed-9781337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97813372022-12-24 Predictive Factors for Poor Outcome following Chemonucleolysis with Condoliase in Lumbar Disc Herniation Takeuchi, Shu Hanakita, Junya Takahashi, Toshiyuki Inoue, Tomoo Minami, Manabu Suda, Izumi Nakamura, Sho Kanematsu, Ryo Medicina (Kaunas) Article Background and Objectives: Condoliase, a chondroitin sulfate ABC endolyase, is a novel and minimally invasive chemonucleolytic drug for lumbar disc herniation. Despite the growing number of treatments for lumbar disc herniation, the predicting factors for poor outcomes following treatment remain unclear. The aim of this study was to determine the predictive factors for unsuccessful clinical outcome following condoliase therapy. Material and Methods: We performed a retrospective single-center analysis of 101 patients who underwent chemonucleolysis with condoliase from January 2019 to December 2021. Patients were divided into good outcome (i.e., favorable outcome) and poor outcome (i.e., requiring additional surgical treatment) groups. Patient demographics and imaging findings were collected. Clinical outcomes were evaluated using the numerical rating scale and Japanese Orthopaedic Association scores at baseline and at 1- and 3-month follow-up. Pretreatment indicators for additional surgery were compared between the 2 groups. Results: There was a significant difference in baseline leg numbness between the good outcome and poor outcome groups (6.27 ± 1.90 vs. 4.42 ± 2.90, respectively; p = 0.033). Of the 101 included patients, 32 received a preoperative computed tomography scan. In those patients, the presence of calcification or ossification in disc hernia occurred more often in the poor outcome group (61.5% vs. 5.3%, respectively; p < 0.001; odds ratio = 22.242; p = 0.014). Receiver-operating characteristics curve analysis for accompanying calcification or ossification showed an area under the curve of 0.858 (95% confidence interval, 0.715–1.000; p = 0.001). Conclusions: Calcified or ossified disc herniation may be useful predictors of unsuccessful treatment in patients with condoliase administration. MDPI 2022-12-18 /pmc/articles/PMC9781337/ /pubmed/36557070 http://dx.doi.org/10.3390/medicina58121868 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Takeuchi, Shu Hanakita, Junya Takahashi, Toshiyuki Inoue, Tomoo Minami, Manabu Suda, Izumi Nakamura, Sho Kanematsu, Ryo Predictive Factors for Poor Outcome following Chemonucleolysis with Condoliase in Lumbar Disc Herniation |
title | Predictive Factors for Poor Outcome following Chemonucleolysis with Condoliase in Lumbar Disc Herniation |
title_full | Predictive Factors for Poor Outcome following Chemonucleolysis with Condoliase in Lumbar Disc Herniation |
title_fullStr | Predictive Factors for Poor Outcome following Chemonucleolysis with Condoliase in Lumbar Disc Herniation |
title_full_unstemmed | Predictive Factors for Poor Outcome following Chemonucleolysis with Condoliase in Lumbar Disc Herniation |
title_short | Predictive Factors for Poor Outcome following Chemonucleolysis with Condoliase in Lumbar Disc Herniation |
title_sort | predictive factors for poor outcome following chemonucleolysis with condoliase in lumbar disc herniation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781337/ https://www.ncbi.nlm.nih.gov/pubmed/36557070 http://dx.doi.org/10.3390/medicina58121868 |
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