A Review: Meridianins and Meridianins Derivatives

Meridianins are a family of indole alkaloids derived from Antarctic tunicates with extensive pharmacological activities. A series of meridianin derivatives had been synthesized by drug researchers. This article reviews the extraction and purification methods, biological activities and pharmacologica...

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Detalles Bibliográficos
Autor principal: Xiao, Linxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781522/
https://www.ncbi.nlm.nih.gov/pubmed/36557848
http://dx.doi.org/10.3390/molecules27248714
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author Xiao, Linxia
author_facet Xiao, Linxia
author_sort Xiao, Linxia
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description Meridianins are a family of indole alkaloids derived from Antarctic tunicates with extensive pharmacological activities. A series of meridianin derivatives had been synthesized by drug researchers. This article reviews the extraction and purification methods, biological activities and pharmacological applications, pharmacokinetic characters and chemical synthesis of meridianins and their derivatives. And prospects on discovering new bioactivities of meridianins and optimizing their structure for the improvement of the ADMET properties are provided.
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spelling pubmed-97815222022-12-24 A Review: Meridianins and Meridianins Derivatives Xiao, Linxia Molecules Review Meridianins are a family of indole alkaloids derived from Antarctic tunicates with extensive pharmacological activities. A series of meridianin derivatives had been synthesized by drug researchers. This article reviews the extraction and purification methods, biological activities and pharmacological applications, pharmacokinetic characters and chemical synthesis of meridianins and their derivatives. And prospects on discovering new bioactivities of meridianins and optimizing their structure for the improvement of the ADMET properties are provided. MDPI 2022-12-09 /pmc/articles/PMC9781522/ /pubmed/36557848 http://dx.doi.org/10.3390/molecules27248714 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xiao, Linxia
A Review: Meridianins and Meridianins Derivatives
title A Review: Meridianins and Meridianins Derivatives
title_full A Review: Meridianins and Meridianins Derivatives
title_fullStr A Review: Meridianins and Meridianins Derivatives
title_full_unstemmed A Review: Meridianins and Meridianins Derivatives
title_short A Review: Meridianins and Meridianins Derivatives
title_sort review: meridianins and meridianins derivatives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781522/
https://www.ncbi.nlm.nih.gov/pubmed/36557848
http://dx.doi.org/10.3390/molecules27248714
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