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Phytochemical Study of Euphorbia turcomanica Boiss.

The attraction to the Euphorbia genus, with its remarkable diversity in species, is due to its variety of chemical compositions. Euphorbia turcomanica is one of the species of the spurge family growing wildly in Iran. This research aims to investigate the presence of secondary metabolites, specially...

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Autores principales: Motinia, Newsha, Ghannadian, Mustafa, Zolfaghari, Behzad, Yazdiniapour, Zeinab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781534/
https://www.ncbi.nlm.nih.gov/pubmed/36557238
http://dx.doi.org/10.3390/metabo12121200
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author Motinia, Newsha
Ghannadian, Mustafa
Zolfaghari, Behzad
Yazdiniapour, Zeinab
author_facet Motinia, Newsha
Ghannadian, Mustafa
Zolfaghari, Behzad
Yazdiniapour, Zeinab
author_sort Motinia, Newsha
collection PubMed
description The attraction to the Euphorbia genus, with its remarkable diversity in species, is due to its variety of chemical compositions. Euphorbia turcomanica is one of the species of the spurge family growing wildly in Iran. This research aims to investigate the presence of secondary metabolites, specially terpenoid compounds, in terms of structural determination. Samples of E. tucomanica were finely powdered and macerated with acetone/dichloromethane 2:1. Repeated column chromatography using silica gel, MPLC, and HPLC methods followed by the analysis of data obtained from spectroscopic means was carried out to purify and identify the terpenoid constituents. The chemical structures of nine known terpenoids were determined for the first time from E. turcomanica during this study. Loliolide (1), a monoterpene, and eight steroids and triterpenes, including simiarenol (2), isomultiflorenol (3), cycloart-25-ene-3β,24-diol (4), β-sitosterol (5), cycloart-23-ene-3β,25-diol (6), 3α, 11α-dihydroxyurs-12-ene (7), 3β, 24β, 25-trihydroxycycloartane (8), and 7α-hydroxystigmasterol (9) were isolated and identified. E. tucomanica, with a rich terpenoid profile, can be one of the valuable and economic sources providing compounds for drug development.
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spelling pubmed-97815342022-12-24 Phytochemical Study of Euphorbia turcomanica Boiss. Motinia, Newsha Ghannadian, Mustafa Zolfaghari, Behzad Yazdiniapour, Zeinab Metabolites Article The attraction to the Euphorbia genus, with its remarkable diversity in species, is due to its variety of chemical compositions. Euphorbia turcomanica is one of the species of the spurge family growing wildly in Iran. This research aims to investigate the presence of secondary metabolites, specially terpenoid compounds, in terms of structural determination. Samples of E. tucomanica were finely powdered and macerated with acetone/dichloromethane 2:1. Repeated column chromatography using silica gel, MPLC, and HPLC methods followed by the analysis of data obtained from spectroscopic means was carried out to purify and identify the terpenoid constituents. The chemical structures of nine known terpenoids were determined for the first time from E. turcomanica during this study. Loliolide (1), a monoterpene, and eight steroids and triterpenes, including simiarenol (2), isomultiflorenol (3), cycloart-25-ene-3β,24-diol (4), β-sitosterol (5), cycloart-23-ene-3β,25-diol (6), 3α, 11α-dihydroxyurs-12-ene (7), 3β, 24β, 25-trihydroxycycloartane (8), and 7α-hydroxystigmasterol (9) were isolated and identified. E. tucomanica, with a rich terpenoid profile, can be one of the valuable and economic sources providing compounds for drug development. MDPI 2022-11-30 /pmc/articles/PMC9781534/ /pubmed/36557238 http://dx.doi.org/10.3390/metabo12121200 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Motinia, Newsha
Ghannadian, Mustafa
Zolfaghari, Behzad
Yazdiniapour, Zeinab
Phytochemical Study of Euphorbia turcomanica Boiss.
title Phytochemical Study of Euphorbia turcomanica Boiss.
title_full Phytochemical Study of Euphorbia turcomanica Boiss.
title_fullStr Phytochemical Study of Euphorbia turcomanica Boiss.
title_full_unstemmed Phytochemical Study of Euphorbia turcomanica Boiss.
title_short Phytochemical Study of Euphorbia turcomanica Boiss.
title_sort phytochemical study of euphorbia turcomanica boiss.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781534/
https://www.ncbi.nlm.nih.gov/pubmed/36557238
http://dx.doi.org/10.3390/metabo12121200
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AT yazdiniapourzeinab phytochemicalstudyofeuphorbiaturcomanicaboiss