Cargando…

Systemic Oxidative Stress in Women with Ovarian and Pelvic Endometriosis: Role of Hormonal Therapy

This study was performed to evaluate the systemic oxidative stress balance in women with either ovarian or deep infiltrating endometriosis (DIE) and any alterations of the same during hormone therapy. Free oxygen radicals (FORT) and free oxidant radical defense (FORD) were measured in the capillary...

Descripción completa

Detalles Bibliográficos
Autores principales: Biasioli, Anna, Xholli, Anjeza, Previtera, Francesca, Balzano, Alessandro, Capodicasa, Valentina, Tassi, Alice, Londero, Ambrogio P., Cagnacci, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781540/
https://www.ncbi.nlm.nih.gov/pubmed/36556076
http://dx.doi.org/10.3390/jcm11247460
_version_ 1784857099322261504
author Biasioli, Anna
Xholli, Anjeza
Previtera, Francesca
Balzano, Alessandro
Capodicasa, Valentina
Tassi, Alice
Londero, Ambrogio P.
Cagnacci, Angelo
author_facet Biasioli, Anna
Xholli, Anjeza
Previtera, Francesca
Balzano, Alessandro
Capodicasa, Valentina
Tassi, Alice
Londero, Ambrogio P.
Cagnacci, Angelo
author_sort Biasioli, Anna
collection PubMed
description This study was performed to evaluate the systemic oxidative stress balance in women with either ovarian or deep infiltrating endometriosis (DIE) and any alterations of the same during hormone therapy. Free oxygen radicals (FORT) and free oxidant radical defense (FORD) were measured in the capillary blood of 24 women without endometriosis, 26 women with endometrioma, and 26 women with DIE with or without endometrioma. Endometriosis was diagnosed by clinical and ultrasound assessment. Dietary factors, lifestyle habits, and intake of any substances interfering with the oxidative status were recorded. Women were prescribed contraceptive hormones, and the baseline assessments were repeated at the 3rd month of use, revealing a higher oxidative stress balance (FORT/FORD) in women with endometriosis than in controls (4.75 ± 4.4 vs. 2.79 ± 2.2; p = 0.05). The highest values were found in women with DIE (5.34 ± 4.6; p = 0.028 vs. controls). Regression analysis revealed an independent link between FORT/FORD and endometrioma (b 2.874, 95% CI 0.345, 5.403; p = 0.027) and DIE (b 4.419, 95% CI 1.775, 7.064; p = 0.001) but a negative correlation with HDL-cholesterol (b −0.063, 95% CI −0.125, −0.002; p = 0.043). In controls, the hormone therapy increased FORT (p = 0.003), but also FORD (p = 0.012), with the FORT/FORD balance remaining stable (2.72 ± 2.2 vs. 2.73 ± 1.8; p = 0.810). In women with endometriosis, FORT remained unchanged, but FORD increased (p = 0.004), and the FORT/FORD ratio significantly decreased (4.75 ± 4.4 vs. 2.57 ± 1.76; p = 0.002) to values similar to the control levels. These data indicate that systemic oxidative stress balance increased in women with endometriosis, particularly in those with DIE. The hormonal therapy did not change the oxidative stress balance in control women but significantly improved it in women with endometriosis, particularly those suffering from DIE.
format Online
Article
Text
id pubmed-9781540
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97815402022-12-24 Systemic Oxidative Stress in Women with Ovarian and Pelvic Endometriosis: Role of Hormonal Therapy Biasioli, Anna Xholli, Anjeza Previtera, Francesca Balzano, Alessandro Capodicasa, Valentina Tassi, Alice Londero, Ambrogio P. Cagnacci, Angelo J Clin Med Article This study was performed to evaluate the systemic oxidative stress balance in women with either ovarian or deep infiltrating endometriosis (DIE) and any alterations of the same during hormone therapy. Free oxygen radicals (FORT) and free oxidant radical defense (FORD) were measured in the capillary blood of 24 women without endometriosis, 26 women with endometrioma, and 26 women with DIE with or without endometrioma. Endometriosis was diagnosed by clinical and ultrasound assessment. Dietary factors, lifestyle habits, and intake of any substances interfering with the oxidative status were recorded. Women were prescribed contraceptive hormones, and the baseline assessments were repeated at the 3rd month of use, revealing a higher oxidative stress balance (FORT/FORD) in women with endometriosis than in controls (4.75 ± 4.4 vs. 2.79 ± 2.2; p = 0.05). The highest values were found in women with DIE (5.34 ± 4.6; p = 0.028 vs. controls). Regression analysis revealed an independent link between FORT/FORD and endometrioma (b 2.874, 95% CI 0.345, 5.403; p = 0.027) and DIE (b 4.419, 95% CI 1.775, 7.064; p = 0.001) but a negative correlation with HDL-cholesterol (b −0.063, 95% CI −0.125, −0.002; p = 0.043). In controls, the hormone therapy increased FORT (p = 0.003), but also FORD (p = 0.012), with the FORT/FORD balance remaining stable (2.72 ± 2.2 vs. 2.73 ± 1.8; p = 0.810). In women with endometriosis, FORT remained unchanged, but FORD increased (p = 0.004), and the FORT/FORD ratio significantly decreased (4.75 ± 4.4 vs. 2.57 ± 1.76; p = 0.002) to values similar to the control levels. These data indicate that systemic oxidative stress balance increased in women with endometriosis, particularly in those with DIE. The hormonal therapy did not change the oxidative stress balance in control women but significantly improved it in women with endometriosis, particularly those suffering from DIE. MDPI 2022-12-16 /pmc/articles/PMC9781540/ /pubmed/36556076 http://dx.doi.org/10.3390/jcm11247460 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Biasioli, Anna
Xholli, Anjeza
Previtera, Francesca
Balzano, Alessandro
Capodicasa, Valentina
Tassi, Alice
Londero, Ambrogio P.
Cagnacci, Angelo
Systemic Oxidative Stress in Women with Ovarian and Pelvic Endometriosis: Role of Hormonal Therapy
title Systemic Oxidative Stress in Women with Ovarian and Pelvic Endometriosis: Role of Hormonal Therapy
title_full Systemic Oxidative Stress in Women with Ovarian and Pelvic Endometriosis: Role of Hormonal Therapy
title_fullStr Systemic Oxidative Stress in Women with Ovarian and Pelvic Endometriosis: Role of Hormonal Therapy
title_full_unstemmed Systemic Oxidative Stress in Women with Ovarian and Pelvic Endometriosis: Role of Hormonal Therapy
title_short Systemic Oxidative Stress in Women with Ovarian and Pelvic Endometriosis: Role of Hormonal Therapy
title_sort systemic oxidative stress in women with ovarian and pelvic endometriosis: role of hormonal therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781540/
https://www.ncbi.nlm.nih.gov/pubmed/36556076
http://dx.doi.org/10.3390/jcm11247460
work_keys_str_mv AT biasiolianna systemicoxidativestressinwomenwithovarianandpelvicendometriosisroleofhormonaltherapy
AT xhollianjeza systemicoxidativestressinwomenwithovarianandpelvicendometriosisroleofhormonaltherapy
AT previterafrancesca systemicoxidativestressinwomenwithovarianandpelvicendometriosisroleofhormonaltherapy
AT balzanoalessandro systemicoxidativestressinwomenwithovarianandpelvicendometriosisroleofhormonaltherapy
AT capodicasavalentina systemicoxidativestressinwomenwithovarianandpelvicendometriosisroleofhormonaltherapy
AT tassialice systemicoxidativestressinwomenwithovarianandpelvicendometriosisroleofhormonaltherapy
AT londeroambrogiop systemicoxidativestressinwomenwithovarianandpelvicendometriosisroleofhormonaltherapy
AT cagnacciangelo systemicoxidativestressinwomenwithovarianandpelvicendometriosisroleofhormonaltherapy