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Myocardial Injury Is Associated with the Incidence of Major Adverse Cardiac Events in Patients with Severe Trauma

Background: Severe trauma potentially results in end-organ damage such as myocardial injury. Data suggest that myocardial injury is associated with increased mortality in this cohort, but the association with the incidence of in-hospital major adverse cardiac events (MACE) remains undetermined. Meth...

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Autores principales: Stroda, Alexandra, Jaekel, Carina, M’Pembele, René, Guenther, Alexander, Tenge, Theresa, Thielmann, Carl Maximilian, Thelen, Simon, Schiffner, Erik, Bieler, Dan, Bernhard, Michael, Huhn, Ragnar, Lurati Buse, Giovanna, Roth, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781602/
https://www.ncbi.nlm.nih.gov/pubmed/36556048
http://dx.doi.org/10.3390/jcm11247432
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author Stroda, Alexandra
Jaekel, Carina
M’Pembele, René
Guenther, Alexander
Tenge, Theresa
Thielmann, Carl Maximilian
Thelen, Simon
Schiffner, Erik
Bieler, Dan
Bernhard, Michael
Huhn, Ragnar
Lurati Buse, Giovanna
Roth, Sebastian
author_facet Stroda, Alexandra
Jaekel, Carina
M’Pembele, René
Guenther, Alexander
Tenge, Theresa
Thielmann, Carl Maximilian
Thelen, Simon
Schiffner, Erik
Bieler, Dan
Bernhard, Michael
Huhn, Ragnar
Lurati Buse, Giovanna
Roth, Sebastian
author_sort Stroda, Alexandra
collection PubMed
description Background: Severe trauma potentially results in end-organ damage such as myocardial injury. Data suggest that myocardial injury is associated with increased mortality in this cohort, but the association with the incidence of in-hospital major adverse cardiac events (MACE) remains undetermined. Methods: Retrospective cohort study including adult patients with severe trauma treated at the University Hospital Duesseldorf between January 2016 and December 2019. The main exposure was myocardial injury at presentation. Endpoints were in-hospital incidence of MACE and incidence of acute kidney injury (AKI) within 72 h. Discrimination of hsTnT for MACE and AKI was examined by the receiver operating characteristic curve (ROC) and the area under the curve (AUC). We conducted multivariate logistic regression analysis. Results: We included 353 patients in our final analysis (72.5% male (256/353), age: 55 ± 21 years). The AUC for hsTnT and MACE was 0.68 [95% confidence interval (CI): 0.59–0.78]. The AUC for hsTnT and AKI was 0.64 [95% (CI): 0.55–0.72]. The adjusted odds ratio (OR) for myocardial injury and MACE was 2.97 [95% (CI): 1.31–6.72], and it was 2.14 [95% (CI): 1.03–4.46] for myocardial injury and AKI. Conclusion: Myocardial injury at presentation in patients with severe trauma is independently associated with the incidence of in-hospital MACE and AKI.
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spelling pubmed-97816022022-12-24 Myocardial Injury Is Associated with the Incidence of Major Adverse Cardiac Events in Patients with Severe Trauma Stroda, Alexandra Jaekel, Carina M’Pembele, René Guenther, Alexander Tenge, Theresa Thielmann, Carl Maximilian Thelen, Simon Schiffner, Erik Bieler, Dan Bernhard, Michael Huhn, Ragnar Lurati Buse, Giovanna Roth, Sebastian J Clin Med Article Background: Severe trauma potentially results in end-organ damage such as myocardial injury. Data suggest that myocardial injury is associated with increased mortality in this cohort, but the association with the incidence of in-hospital major adverse cardiac events (MACE) remains undetermined. Methods: Retrospective cohort study including adult patients with severe trauma treated at the University Hospital Duesseldorf between January 2016 and December 2019. The main exposure was myocardial injury at presentation. Endpoints were in-hospital incidence of MACE and incidence of acute kidney injury (AKI) within 72 h. Discrimination of hsTnT for MACE and AKI was examined by the receiver operating characteristic curve (ROC) and the area under the curve (AUC). We conducted multivariate logistic regression analysis. Results: We included 353 patients in our final analysis (72.5% male (256/353), age: 55 ± 21 years). The AUC for hsTnT and MACE was 0.68 [95% confidence interval (CI): 0.59–0.78]. The AUC for hsTnT and AKI was 0.64 [95% (CI): 0.55–0.72]. The adjusted odds ratio (OR) for myocardial injury and MACE was 2.97 [95% (CI): 1.31–6.72], and it was 2.14 [95% (CI): 1.03–4.46] for myocardial injury and AKI. Conclusion: Myocardial injury at presentation in patients with severe trauma is independently associated with the incidence of in-hospital MACE and AKI. MDPI 2022-12-15 /pmc/articles/PMC9781602/ /pubmed/36556048 http://dx.doi.org/10.3390/jcm11247432 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stroda, Alexandra
Jaekel, Carina
M’Pembele, René
Guenther, Alexander
Tenge, Theresa
Thielmann, Carl Maximilian
Thelen, Simon
Schiffner, Erik
Bieler, Dan
Bernhard, Michael
Huhn, Ragnar
Lurati Buse, Giovanna
Roth, Sebastian
Myocardial Injury Is Associated with the Incidence of Major Adverse Cardiac Events in Patients with Severe Trauma
title Myocardial Injury Is Associated with the Incidence of Major Adverse Cardiac Events in Patients with Severe Trauma
title_full Myocardial Injury Is Associated with the Incidence of Major Adverse Cardiac Events in Patients with Severe Trauma
title_fullStr Myocardial Injury Is Associated with the Incidence of Major Adverse Cardiac Events in Patients with Severe Trauma
title_full_unstemmed Myocardial Injury Is Associated with the Incidence of Major Adverse Cardiac Events in Patients with Severe Trauma
title_short Myocardial Injury Is Associated with the Incidence of Major Adverse Cardiac Events in Patients with Severe Trauma
title_sort myocardial injury is associated with the incidence of major adverse cardiac events in patients with severe trauma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781602/
https://www.ncbi.nlm.nih.gov/pubmed/36556048
http://dx.doi.org/10.3390/jcm11247432
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