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Primary Breast Angiosarcoma: Comparative Transcriptome Analysis

Primary breast angiosarcoma, with de novo appearance and not associated with exposure to radiation or lymphedema, is a rare pathology representing less than 0.05% of the neoplasms related to this organ. The pathology is characterized by its aggressiveness, poor prognosis, and difficulties in its dif...

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Autores principales: Rincón-Riveros, Andrés, De la Peña, Jairo, Rubiano, Wilson, Olivella, Fabio, Martinez-Agüero, María, Villegas, Victoria E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781631/
https://www.ncbi.nlm.nih.gov/pubmed/36555675
http://dx.doi.org/10.3390/ijms232416032
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author Rincón-Riveros, Andrés
De la Peña, Jairo
Rubiano, Wilson
Olivella, Fabio
Martinez-Agüero, María
Villegas, Victoria E.
author_facet Rincón-Riveros, Andrés
De la Peña, Jairo
Rubiano, Wilson
Olivella, Fabio
Martinez-Agüero, María
Villegas, Victoria E.
author_sort Rincón-Riveros, Andrés
collection PubMed
description Primary breast angiosarcoma, with de novo appearance and not associated with exposure to radiation or lymphedema, is a rare pathology representing less than 0.05% of the neoplasms related to this organ. The pathology is characterized by its aggressiveness, poor prognosis, and difficulties in its differential diagnosis. This article reports the case of a 55-year-old white woman with no family history of cancer, with a rapidly growing mass in the left mammary gland that ulcerates and bleeds. It is confirmed as primary breast angiosarcoma by immunostaining in the tumor tissue for CD31, CD34, and FLI-1. In addition, a sample of neoplastic and healthy tissues is collected from the patient for RNA sequencing; the results are contrasted with a tissue sample from a patient with Luminal A subtype of breast cancer, as well as data from other cases of angiosarcoma available in public databases. These findings revealed a genetic profile associated with the immune and inflammatory response in the patient’s sample when compared to available angiosarcoma data; these molecular patterns are consistent with other recent studies. Due to the rarity of the disease, the studies carried out on each patient contribute to the expanding knowledge of the etiology and molecular pathways that are still partially known and continue to be the subject of research. Aside from a comparative transcriptome study, this article aims to provide an update on the state of knowledge about this disease.
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spelling pubmed-97816312022-12-24 Primary Breast Angiosarcoma: Comparative Transcriptome Analysis Rincón-Riveros, Andrés De la Peña, Jairo Rubiano, Wilson Olivella, Fabio Martinez-Agüero, María Villegas, Victoria E. Int J Mol Sci Case Report Primary breast angiosarcoma, with de novo appearance and not associated with exposure to radiation or lymphedema, is a rare pathology representing less than 0.05% of the neoplasms related to this organ. The pathology is characterized by its aggressiveness, poor prognosis, and difficulties in its differential diagnosis. This article reports the case of a 55-year-old white woman with no family history of cancer, with a rapidly growing mass in the left mammary gland that ulcerates and bleeds. It is confirmed as primary breast angiosarcoma by immunostaining in the tumor tissue for CD31, CD34, and FLI-1. In addition, a sample of neoplastic and healthy tissues is collected from the patient for RNA sequencing; the results are contrasted with a tissue sample from a patient with Luminal A subtype of breast cancer, as well as data from other cases of angiosarcoma available in public databases. These findings revealed a genetic profile associated with the immune and inflammatory response in the patient’s sample when compared to available angiosarcoma data; these molecular patterns are consistent with other recent studies. Due to the rarity of the disease, the studies carried out on each patient contribute to the expanding knowledge of the etiology and molecular pathways that are still partially known and continue to be the subject of research. Aside from a comparative transcriptome study, this article aims to provide an update on the state of knowledge about this disease. MDPI 2022-12-16 /pmc/articles/PMC9781631/ /pubmed/36555675 http://dx.doi.org/10.3390/ijms232416032 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Rincón-Riveros, Andrés
De la Peña, Jairo
Rubiano, Wilson
Olivella, Fabio
Martinez-Agüero, María
Villegas, Victoria E.
Primary Breast Angiosarcoma: Comparative Transcriptome Analysis
title Primary Breast Angiosarcoma: Comparative Transcriptome Analysis
title_full Primary Breast Angiosarcoma: Comparative Transcriptome Analysis
title_fullStr Primary Breast Angiosarcoma: Comparative Transcriptome Analysis
title_full_unstemmed Primary Breast Angiosarcoma: Comparative Transcriptome Analysis
title_short Primary Breast Angiosarcoma: Comparative Transcriptome Analysis
title_sort primary breast angiosarcoma: comparative transcriptome analysis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781631/
https://www.ncbi.nlm.nih.gov/pubmed/36555675
http://dx.doi.org/10.3390/ijms232416032
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