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Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification
Sinomenine is the main component of the vine Sinomenium acutum. It was first isolated in the early 1920s and has since attracted special interest as a potential anti-rheumatoid arthritis (RA) agent, owing to its successful application in traditional Chinese medicine for the treatment of neuralgia an...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781648/ https://www.ncbi.nlm.nih.gov/pubmed/36557779 http://dx.doi.org/10.3390/molecules27248645 |
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author | Zhang, Cuili Zhang, Shujie Liao, Jingjing Gong, Zipeng Chai, Xin Lyu, Haining |
author_facet | Zhang, Cuili Zhang, Shujie Liao, Jingjing Gong, Zipeng Chai, Xin Lyu, Haining |
author_sort | Zhang, Cuili |
collection | PubMed |
description | Sinomenine is the main component of the vine Sinomenium acutum. It was first isolated in the early 1920s and has since attracted special interest as a potential anti-rheumatoid arthritis (RA) agent, owing to its successful application in traditional Chinese medicine for the treatment of neuralgia and rheumatoid diseases. In the past few decades, significant advances have broadened our understanding of the molecular mechanisms through which sinomenine treats RA, as well as the structural modifications necessary for improved pharmacological activity. In this review, we summarize up-to-date reports on the pharmacological properties of sinomenine in RA treatment, document their underlying mechanisms, and provide an overview of promising sinomenine derivatives as potential RA drug therapies. |
format | Online Article Text |
id | pubmed-9781648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97816482022-12-24 Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification Zhang, Cuili Zhang, Shujie Liao, Jingjing Gong, Zipeng Chai, Xin Lyu, Haining Molecules Review Sinomenine is the main component of the vine Sinomenium acutum. It was first isolated in the early 1920s and has since attracted special interest as a potential anti-rheumatoid arthritis (RA) agent, owing to its successful application in traditional Chinese medicine for the treatment of neuralgia and rheumatoid diseases. In the past few decades, significant advances have broadened our understanding of the molecular mechanisms through which sinomenine treats RA, as well as the structural modifications necessary for improved pharmacological activity. In this review, we summarize up-to-date reports on the pharmacological properties of sinomenine in RA treatment, document their underlying mechanisms, and provide an overview of promising sinomenine derivatives as potential RA drug therapies. MDPI 2022-12-07 /pmc/articles/PMC9781648/ /pubmed/36557779 http://dx.doi.org/10.3390/molecules27248645 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Cuili Zhang, Shujie Liao, Jingjing Gong, Zipeng Chai, Xin Lyu, Haining Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification |
title | Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification |
title_full | Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification |
title_fullStr | Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification |
title_full_unstemmed | Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification |
title_short | Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification |
title_sort | towards better sinomenine-type drugs to treat rheumatoid arthritis: molecular mechanisms and structural modification |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781648/ https://www.ncbi.nlm.nih.gov/pubmed/36557779 http://dx.doi.org/10.3390/molecules27248645 |
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