Cargando…

Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification

Sinomenine is the main component of the vine Sinomenium acutum. It was first isolated in the early 1920s and has since attracted special interest as a potential anti-rheumatoid arthritis (RA) agent, owing to its successful application in traditional Chinese medicine for the treatment of neuralgia an...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Cuili, Zhang, Shujie, Liao, Jingjing, Gong, Zipeng, Chai, Xin, Lyu, Haining
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781648/
https://www.ncbi.nlm.nih.gov/pubmed/36557779
http://dx.doi.org/10.3390/molecules27248645
_version_ 1784857125736939520
author Zhang, Cuili
Zhang, Shujie
Liao, Jingjing
Gong, Zipeng
Chai, Xin
Lyu, Haining
author_facet Zhang, Cuili
Zhang, Shujie
Liao, Jingjing
Gong, Zipeng
Chai, Xin
Lyu, Haining
author_sort Zhang, Cuili
collection PubMed
description Sinomenine is the main component of the vine Sinomenium acutum. It was first isolated in the early 1920s and has since attracted special interest as a potential anti-rheumatoid arthritis (RA) agent, owing to its successful application in traditional Chinese medicine for the treatment of neuralgia and rheumatoid diseases. In the past few decades, significant advances have broadened our understanding of the molecular mechanisms through which sinomenine treats RA, as well as the structural modifications necessary for improved pharmacological activity. In this review, we summarize up-to-date reports on the pharmacological properties of sinomenine in RA treatment, document their underlying mechanisms, and provide an overview of promising sinomenine derivatives as potential RA drug therapies.
format Online
Article
Text
id pubmed-9781648
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97816482022-12-24 Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification Zhang, Cuili Zhang, Shujie Liao, Jingjing Gong, Zipeng Chai, Xin Lyu, Haining Molecules Review Sinomenine is the main component of the vine Sinomenium acutum. It was first isolated in the early 1920s and has since attracted special interest as a potential anti-rheumatoid arthritis (RA) agent, owing to its successful application in traditional Chinese medicine for the treatment of neuralgia and rheumatoid diseases. In the past few decades, significant advances have broadened our understanding of the molecular mechanisms through which sinomenine treats RA, as well as the structural modifications necessary for improved pharmacological activity. In this review, we summarize up-to-date reports on the pharmacological properties of sinomenine in RA treatment, document their underlying mechanisms, and provide an overview of promising sinomenine derivatives as potential RA drug therapies. MDPI 2022-12-07 /pmc/articles/PMC9781648/ /pubmed/36557779 http://dx.doi.org/10.3390/molecules27248645 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Cuili
Zhang, Shujie
Liao, Jingjing
Gong, Zipeng
Chai, Xin
Lyu, Haining
Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification
title Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification
title_full Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification
title_fullStr Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification
title_full_unstemmed Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification
title_short Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification
title_sort towards better sinomenine-type drugs to treat rheumatoid arthritis: molecular mechanisms and structural modification
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781648/
https://www.ncbi.nlm.nih.gov/pubmed/36557779
http://dx.doi.org/10.3390/molecules27248645
work_keys_str_mv AT zhangcuili towardsbettersinomeninetypedrugstotreatrheumatoidarthritismolecularmechanismsandstructuralmodification
AT zhangshujie towardsbettersinomeninetypedrugstotreatrheumatoidarthritismolecularmechanismsandstructuralmodification
AT liaojingjing towardsbettersinomeninetypedrugstotreatrheumatoidarthritismolecularmechanismsandstructuralmodification
AT gongzipeng towardsbettersinomeninetypedrugstotreatrheumatoidarthritismolecularmechanismsandstructuralmodification
AT chaixin towardsbettersinomeninetypedrugstotreatrheumatoidarthritismolecularmechanismsandstructuralmodification
AT lyuhaining towardsbettersinomeninetypedrugstotreatrheumatoidarthritismolecularmechanismsandstructuralmodification