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Thyrotropin Levels in Patients with Coronavirus Disease 2019: Assessment during Hospitalization and in the Medium Term after Discharge

Background: The objectives of this study were (1) to compare TSH levels between inpatients with critical versus non-critical coronavirus disease 19 (COVID-19), and (2) to describe the status of TSH levels three months after hospitalization. Methods: We collected data on adult patients hospitalized w...

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Autores principales: Al-Salameh, Abdallah, Scherman, Noémie, Adda, Imane, André, Juliette, Zerbib, Yoann, Maizel, Julien, Lalau, Jean-Daniel, Brochot, Etienne, Andrejak, Claire, Desailloud, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781661/
https://www.ncbi.nlm.nih.gov/pubmed/36556379
http://dx.doi.org/10.3390/life12122014
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author Al-Salameh, Abdallah
Scherman, Noémie
Adda, Imane
André, Juliette
Zerbib, Yoann
Maizel, Julien
Lalau, Jean-Daniel
Brochot, Etienne
Andrejak, Claire
Desailloud, Rachel
author_facet Al-Salameh, Abdallah
Scherman, Noémie
Adda, Imane
André, Juliette
Zerbib, Yoann
Maizel, Julien
Lalau, Jean-Daniel
Brochot, Etienne
Andrejak, Claire
Desailloud, Rachel
author_sort Al-Salameh, Abdallah
collection PubMed
description Background: The objectives of this study were (1) to compare TSH levels between inpatients with critical versus non-critical coronavirus disease 19 (COVID-19), and (2) to describe the status of TSH levels three months after hospitalization. Methods: We collected data on adult patients hospitalized with COVID-19 at Amiens University Hospital. We compared TSH levels between inpatients with critical (intensive care unit admission and/or death) versus non-critical COVID-19. Thereafter, survivors were invited to return for a three-month post-discharge visit where thyroid function tests were performed, regardless of the availability of TSH measurement during hospitalization. Results: Among 448 inpatients with COVID-19, TSH assay data during hospitalization were available for 139 patients without prior thyroid disease. Patients with critical and non-critical forms of COVID-19 did not differ significantly with regard to the median (interquartile range) TSH level (0.96 (0.68–1.71) vs. 1.27 mIU/L (0.75–1.79), p = 0.40). Abnormal TSH level was encountered in 17 patients (12.2%); most of them had subclinical thyroid disease. TSH assay data at the three-month post-discharge visit were available for 151 patients without prior thyroid disease. Only seven of them (4.6%) had abnormal TSH levels. Median TSH level at the post-discharge visit was significantly higher than median TSH level during hospitalization. Conclusions: Our findings suggest that COVID-19 is associated with a transient suppression of TSH in a minority of patients regardless of the clinical form. The higher TSH levels three months after COVID-19 might suggest recovery from non-thyroidal illness syndrome.
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spelling pubmed-97816612022-12-24 Thyrotropin Levels in Patients with Coronavirus Disease 2019: Assessment during Hospitalization and in the Medium Term after Discharge Al-Salameh, Abdallah Scherman, Noémie Adda, Imane André, Juliette Zerbib, Yoann Maizel, Julien Lalau, Jean-Daniel Brochot, Etienne Andrejak, Claire Desailloud, Rachel Life (Basel) Article Background: The objectives of this study were (1) to compare TSH levels between inpatients with critical versus non-critical coronavirus disease 19 (COVID-19), and (2) to describe the status of TSH levels three months after hospitalization. Methods: We collected data on adult patients hospitalized with COVID-19 at Amiens University Hospital. We compared TSH levels between inpatients with critical (intensive care unit admission and/or death) versus non-critical COVID-19. Thereafter, survivors were invited to return for a three-month post-discharge visit where thyroid function tests were performed, regardless of the availability of TSH measurement during hospitalization. Results: Among 448 inpatients with COVID-19, TSH assay data during hospitalization were available for 139 patients without prior thyroid disease. Patients with critical and non-critical forms of COVID-19 did not differ significantly with regard to the median (interquartile range) TSH level (0.96 (0.68–1.71) vs. 1.27 mIU/L (0.75–1.79), p = 0.40). Abnormal TSH level was encountered in 17 patients (12.2%); most of them had subclinical thyroid disease. TSH assay data at the three-month post-discharge visit were available for 151 patients without prior thyroid disease. Only seven of them (4.6%) had abnormal TSH levels. Median TSH level at the post-discharge visit was significantly higher than median TSH level during hospitalization. Conclusions: Our findings suggest that COVID-19 is associated with a transient suppression of TSH in a minority of patients regardless of the clinical form. The higher TSH levels three months after COVID-19 might suggest recovery from non-thyroidal illness syndrome. MDPI 2022-12-02 /pmc/articles/PMC9781661/ /pubmed/36556379 http://dx.doi.org/10.3390/life12122014 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Al-Salameh, Abdallah
Scherman, Noémie
Adda, Imane
André, Juliette
Zerbib, Yoann
Maizel, Julien
Lalau, Jean-Daniel
Brochot, Etienne
Andrejak, Claire
Desailloud, Rachel
Thyrotropin Levels in Patients with Coronavirus Disease 2019: Assessment during Hospitalization and in the Medium Term after Discharge
title Thyrotropin Levels in Patients with Coronavirus Disease 2019: Assessment during Hospitalization and in the Medium Term after Discharge
title_full Thyrotropin Levels in Patients with Coronavirus Disease 2019: Assessment during Hospitalization and in the Medium Term after Discharge
title_fullStr Thyrotropin Levels in Patients with Coronavirus Disease 2019: Assessment during Hospitalization and in the Medium Term after Discharge
title_full_unstemmed Thyrotropin Levels in Patients with Coronavirus Disease 2019: Assessment during Hospitalization and in the Medium Term after Discharge
title_short Thyrotropin Levels in Patients with Coronavirus Disease 2019: Assessment during Hospitalization and in the Medium Term after Discharge
title_sort thyrotropin levels in patients with coronavirus disease 2019: assessment during hospitalization and in the medium term after discharge
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781661/
https://www.ncbi.nlm.nih.gov/pubmed/36556379
http://dx.doi.org/10.3390/life12122014
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