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The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients
Background: The ongoing COVID-19 pandemic has put a constant strain on hospital resources, so there is a dire need for investigation methods that are widely available and that can predict mortality and the need for critical care. Hematological indices, which can be easily calculated from a complete...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781715/ https://www.ncbi.nlm.nih.gov/pubmed/36556258 http://dx.doi.org/10.3390/jpm12122037 |
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author | Chelariu, Andrei-Costin Coman, Adorata Elena Lionte, Catalina Gorciac, Victoria Sorodoc, Victorita Haliga, Raluca Ecaterina Petris, Ovidiu Rusalim Bologa, Cristina Puha, Gabriela Stoica, Alexandra Constantin, Mihai Sirbu, Oana Ceasovschih, Alexandr Sorodoc, Laurentiu |
author_facet | Chelariu, Andrei-Costin Coman, Adorata Elena Lionte, Catalina Gorciac, Victoria Sorodoc, Victorita Haliga, Raluca Ecaterina Petris, Ovidiu Rusalim Bologa, Cristina Puha, Gabriela Stoica, Alexandra Constantin, Mihai Sirbu, Oana Ceasovschih, Alexandr Sorodoc, Laurentiu |
author_sort | Chelariu, Andrei-Costin |
collection | PubMed |
description | Background: The ongoing COVID-19 pandemic has put a constant strain on hospital resources, so there is a dire need for investigation methods that are widely available and that can predict mortality and the need for critical care. Hematological indices, which can be easily calculated from a complete blood count (CBC), are useful in determining a patient’s inflammatory response to infectious diseases. Aim: This was a prospective cohort study that aimed to assess the prognostic value of scores based on CBCs in hospitalized patients with mild or moderate COVID-19 and medical comorbidities regarding the need for intensive care unit (ICU) therapy and short-term mortality. Methods: We included 607 patients with confirmed COVID-19, followed up for the need for ICU admission (15.5%) and 30 day mortality post-discharge (21.7%). CBC-derived scores were tested upon emergency department (ED) admission and after a median of 8 days. Results: In a multivariate model, elevated followed-up neutrophil-to-lymphocyte ratio (NLR) predicted increased odds for ICU admission (OR: 1.14 [95%CI: 1.06–1.22], p < 0.001) and short-term mortality (OR: 1.30 [95%CI: 1.09–1.57], p = 0.005). Monocyte-to-lymphocyte ratio (MLR) predicted 2.5-fold increased odds for ICU admission and 2.2-fold increased odds for mortality. Conclusion: NLR and MLR followed up 8 days post-admission are predictive for adverse outcomes in mild or moderate COVID-19 patients. |
format | Online Article Text |
id | pubmed-9781715 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97817152022-12-24 The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients Chelariu, Andrei-Costin Coman, Adorata Elena Lionte, Catalina Gorciac, Victoria Sorodoc, Victorita Haliga, Raluca Ecaterina Petris, Ovidiu Rusalim Bologa, Cristina Puha, Gabriela Stoica, Alexandra Constantin, Mihai Sirbu, Oana Ceasovschih, Alexandr Sorodoc, Laurentiu J Pers Med Article Background: The ongoing COVID-19 pandemic has put a constant strain on hospital resources, so there is a dire need for investigation methods that are widely available and that can predict mortality and the need for critical care. Hematological indices, which can be easily calculated from a complete blood count (CBC), are useful in determining a patient’s inflammatory response to infectious diseases. Aim: This was a prospective cohort study that aimed to assess the prognostic value of scores based on CBCs in hospitalized patients with mild or moderate COVID-19 and medical comorbidities regarding the need for intensive care unit (ICU) therapy and short-term mortality. Methods: We included 607 patients with confirmed COVID-19, followed up for the need for ICU admission (15.5%) and 30 day mortality post-discharge (21.7%). CBC-derived scores were tested upon emergency department (ED) admission and after a median of 8 days. Results: In a multivariate model, elevated followed-up neutrophil-to-lymphocyte ratio (NLR) predicted increased odds for ICU admission (OR: 1.14 [95%CI: 1.06–1.22], p < 0.001) and short-term mortality (OR: 1.30 [95%CI: 1.09–1.57], p = 0.005). Monocyte-to-lymphocyte ratio (MLR) predicted 2.5-fold increased odds for ICU admission and 2.2-fold increased odds for mortality. Conclusion: NLR and MLR followed up 8 days post-admission are predictive for adverse outcomes in mild or moderate COVID-19 patients. MDPI 2022-12-09 /pmc/articles/PMC9781715/ /pubmed/36556258 http://dx.doi.org/10.3390/jpm12122037 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chelariu, Andrei-Costin Coman, Adorata Elena Lionte, Catalina Gorciac, Victoria Sorodoc, Victorita Haliga, Raluca Ecaterina Petris, Ovidiu Rusalim Bologa, Cristina Puha, Gabriela Stoica, Alexandra Constantin, Mihai Sirbu, Oana Ceasovschih, Alexandr Sorodoc, Laurentiu The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients |
title | The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients |
title_full | The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients |
title_fullStr | The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients |
title_full_unstemmed | The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients |
title_short | The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients |
title_sort | value of early and follow-up elevated scores based on peripheral complete blood cell count for predicting adverse outcomes in covid-19 patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781715/ https://www.ncbi.nlm.nih.gov/pubmed/36556258 http://dx.doi.org/10.3390/jpm12122037 |
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