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The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients

Background: The ongoing COVID-19 pandemic has put a constant strain on hospital resources, so there is a dire need for investigation methods that are widely available and that can predict mortality and the need for critical care. Hematological indices, which can be easily calculated from a complete...

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Autores principales: Chelariu, Andrei-Costin, Coman, Adorata Elena, Lionte, Catalina, Gorciac, Victoria, Sorodoc, Victorita, Haliga, Raluca Ecaterina, Petris, Ovidiu Rusalim, Bologa, Cristina, Puha, Gabriela, Stoica, Alexandra, Constantin, Mihai, Sirbu, Oana, Ceasovschih, Alexandr, Sorodoc, Laurentiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781715/
https://www.ncbi.nlm.nih.gov/pubmed/36556258
http://dx.doi.org/10.3390/jpm12122037
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author Chelariu, Andrei-Costin
Coman, Adorata Elena
Lionte, Catalina
Gorciac, Victoria
Sorodoc, Victorita
Haliga, Raluca Ecaterina
Petris, Ovidiu Rusalim
Bologa, Cristina
Puha, Gabriela
Stoica, Alexandra
Constantin, Mihai
Sirbu, Oana
Ceasovschih, Alexandr
Sorodoc, Laurentiu
author_facet Chelariu, Andrei-Costin
Coman, Adorata Elena
Lionte, Catalina
Gorciac, Victoria
Sorodoc, Victorita
Haliga, Raluca Ecaterina
Petris, Ovidiu Rusalim
Bologa, Cristina
Puha, Gabriela
Stoica, Alexandra
Constantin, Mihai
Sirbu, Oana
Ceasovschih, Alexandr
Sorodoc, Laurentiu
author_sort Chelariu, Andrei-Costin
collection PubMed
description Background: The ongoing COVID-19 pandemic has put a constant strain on hospital resources, so there is a dire need for investigation methods that are widely available and that can predict mortality and the need for critical care. Hematological indices, which can be easily calculated from a complete blood count (CBC), are useful in determining a patient’s inflammatory response to infectious diseases. Aim: This was a prospective cohort study that aimed to assess the prognostic value of scores based on CBCs in hospitalized patients with mild or moderate COVID-19 and medical comorbidities regarding the need for intensive care unit (ICU) therapy and short-term mortality. Methods: We included 607 patients with confirmed COVID-19, followed up for the need for ICU admission (15.5%) and 30 day mortality post-discharge (21.7%). CBC-derived scores were tested upon emergency department (ED) admission and after a median of 8 days. Results: In a multivariate model, elevated followed-up neutrophil-to-lymphocyte ratio (NLR) predicted increased odds for ICU admission (OR: 1.14 [95%CI: 1.06–1.22], p < 0.001) and short-term mortality (OR: 1.30 [95%CI: 1.09–1.57], p = 0.005). Monocyte-to-lymphocyte ratio (MLR) predicted 2.5-fold increased odds for ICU admission and 2.2-fold increased odds for mortality. Conclusion: NLR and MLR followed up 8 days post-admission are predictive for adverse outcomes in mild or moderate COVID-19 patients.
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spelling pubmed-97817152022-12-24 The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients Chelariu, Andrei-Costin Coman, Adorata Elena Lionte, Catalina Gorciac, Victoria Sorodoc, Victorita Haliga, Raluca Ecaterina Petris, Ovidiu Rusalim Bologa, Cristina Puha, Gabriela Stoica, Alexandra Constantin, Mihai Sirbu, Oana Ceasovschih, Alexandr Sorodoc, Laurentiu J Pers Med Article Background: The ongoing COVID-19 pandemic has put a constant strain on hospital resources, so there is a dire need for investigation methods that are widely available and that can predict mortality and the need for critical care. Hematological indices, which can be easily calculated from a complete blood count (CBC), are useful in determining a patient’s inflammatory response to infectious diseases. Aim: This was a prospective cohort study that aimed to assess the prognostic value of scores based on CBCs in hospitalized patients with mild or moderate COVID-19 and medical comorbidities regarding the need for intensive care unit (ICU) therapy and short-term mortality. Methods: We included 607 patients with confirmed COVID-19, followed up for the need for ICU admission (15.5%) and 30 day mortality post-discharge (21.7%). CBC-derived scores were tested upon emergency department (ED) admission and after a median of 8 days. Results: In a multivariate model, elevated followed-up neutrophil-to-lymphocyte ratio (NLR) predicted increased odds for ICU admission (OR: 1.14 [95%CI: 1.06–1.22], p < 0.001) and short-term mortality (OR: 1.30 [95%CI: 1.09–1.57], p = 0.005). Monocyte-to-lymphocyte ratio (MLR) predicted 2.5-fold increased odds for ICU admission and 2.2-fold increased odds for mortality. Conclusion: NLR and MLR followed up 8 days post-admission are predictive for adverse outcomes in mild or moderate COVID-19 patients. MDPI 2022-12-09 /pmc/articles/PMC9781715/ /pubmed/36556258 http://dx.doi.org/10.3390/jpm12122037 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chelariu, Andrei-Costin
Coman, Adorata Elena
Lionte, Catalina
Gorciac, Victoria
Sorodoc, Victorita
Haliga, Raluca Ecaterina
Petris, Ovidiu Rusalim
Bologa, Cristina
Puha, Gabriela
Stoica, Alexandra
Constantin, Mihai
Sirbu, Oana
Ceasovschih, Alexandr
Sorodoc, Laurentiu
The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients
title The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients
title_full The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients
title_fullStr The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients
title_full_unstemmed The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients
title_short The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients
title_sort value of early and follow-up elevated scores based on peripheral complete blood cell count for predicting adverse outcomes in covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781715/
https://www.ncbi.nlm.nih.gov/pubmed/36556258
http://dx.doi.org/10.3390/jpm12122037
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