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The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea
The human body contains a very complex and dynamic ecosystem of bacteria. The bacteriome interacts with the host bi-directionally, and changes in either factor impact the entire system. It has long been known that chronic airway diseases are associated with disturbances in the lung bacteriome. Howev...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781820/ https://www.ncbi.nlm.nih.gov/pubmed/36557710 http://dx.doi.org/10.3390/microorganisms10122457 |
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author | Bikov, Andras Dragonieri, Silvano Csoma, Balazs Mazzuca, Carmen Finamore, Panaiotis Rocchi, Giulia Putignani, Lorenza Guarino, Michele Scarlata, Simone |
author_facet | Bikov, Andras Dragonieri, Silvano Csoma, Balazs Mazzuca, Carmen Finamore, Panaiotis Rocchi, Giulia Putignani, Lorenza Guarino, Michele Scarlata, Simone |
author_sort | Bikov, Andras |
collection | PubMed |
description | The human body contains a very complex and dynamic ecosystem of bacteria. The bacteriome interacts with the host bi-directionally, and changes in either factor impact the entire system. It has long been known that chronic airway diseases are associated with disturbances in the lung bacteriome. However, less is known about the role of gut bacteriome in the most common respiratory diseases. Here, we aim to summarise the evidence concerning the role of the intestinal bacteriome in the pathogenesis and disease course of bronchial asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea. Furthermore, we discuss the consequences of an altered gut bacteriome on the most common comorbidities of these lung diseases. Lastly, we also reflect on the therapeutic potential of influencing the gut microbiome to improve disease outcomes. |
format | Online Article Text |
id | pubmed-9781820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97818202022-12-24 The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea Bikov, Andras Dragonieri, Silvano Csoma, Balazs Mazzuca, Carmen Finamore, Panaiotis Rocchi, Giulia Putignani, Lorenza Guarino, Michele Scarlata, Simone Microorganisms Review The human body contains a very complex and dynamic ecosystem of bacteria. The bacteriome interacts with the host bi-directionally, and changes in either factor impact the entire system. It has long been known that chronic airway diseases are associated with disturbances in the lung bacteriome. However, less is known about the role of gut bacteriome in the most common respiratory diseases. Here, we aim to summarise the evidence concerning the role of the intestinal bacteriome in the pathogenesis and disease course of bronchial asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea. Furthermore, we discuss the consequences of an altered gut bacteriome on the most common comorbidities of these lung diseases. Lastly, we also reflect on the therapeutic potential of influencing the gut microbiome to improve disease outcomes. MDPI 2022-12-13 /pmc/articles/PMC9781820/ /pubmed/36557710 http://dx.doi.org/10.3390/microorganisms10122457 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bikov, Andras Dragonieri, Silvano Csoma, Balazs Mazzuca, Carmen Finamore, Panaiotis Rocchi, Giulia Putignani, Lorenza Guarino, Michele Scarlata, Simone The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea |
title | The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea |
title_full | The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea |
title_fullStr | The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea |
title_full_unstemmed | The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea |
title_short | The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea |
title_sort | role of gut bacteriome in asthma, chronic obstructive pulmonary disease and obstructive sleep apnoea |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781820/ https://www.ncbi.nlm.nih.gov/pubmed/36557710 http://dx.doi.org/10.3390/microorganisms10122457 |
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