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The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea

The human body contains a very complex and dynamic ecosystem of bacteria. The bacteriome interacts with the host bi-directionally, and changes in either factor impact the entire system. It has long been known that chronic airway diseases are associated with disturbances in the lung bacteriome. Howev...

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Autores principales: Bikov, Andras, Dragonieri, Silvano, Csoma, Balazs, Mazzuca, Carmen, Finamore, Panaiotis, Rocchi, Giulia, Putignani, Lorenza, Guarino, Michele, Scarlata, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781820/
https://www.ncbi.nlm.nih.gov/pubmed/36557710
http://dx.doi.org/10.3390/microorganisms10122457
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author Bikov, Andras
Dragonieri, Silvano
Csoma, Balazs
Mazzuca, Carmen
Finamore, Panaiotis
Rocchi, Giulia
Putignani, Lorenza
Guarino, Michele
Scarlata, Simone
author_facet Bikov, Andras
Dragonieri, Silvano
Csoma, Balazs
Mazzuca, Carmen
Finamore, Panaiotis
Rocchi, Giulia
Putignani, Lorenza
Guarino, Michele
Scarlata, Simone
author_sort Bikov, Andras
collection PubMed
description The human body contains a very complex and dynamic ecosystem of bacteria. The bacteriome interacts with the host bi-directionally, and changes in either factor impact the entire system. It has long been known that chronic airway diseases are associated with disturbances in the lung bacteriome. However, less is known about the role of gut bacteriome in the most common respiratory diseases. Here, we aim to summarise the evidence concerning the role of the intestinal bacteriome in the pathogenesis and disease course of bronchial asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea. Furthermore, we discuss the consequences of an altered gut bacteriome on the most common comorbidities of these lung diseases. Lastly, we also reflect on the therapeutic potential of influencing the gut microbiome to improve disease outcomes.
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spelling pubmed-97818202022-12-24 The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea Bikov, Andras Dragonieri, Silvano Csoma, Balazs Mazzuca, Carmen Finamore, Panaiotis Rocchi, Giulia Putignani, Lorenza Guarino, Michele Scarlata, Simone Microorganisms Review The human body contains a very complex and dynamic ecosystem of bacteria. The bacteriome interacts with the host bi-directionally, and changes in either factor impact the entire system. It has long been known that chronic airway diseases are associated with disturbances in the lung bacteriome. However, less is known about the role of gut bacteriome in the most common respiratory diseases. Here, we aim to summarise the evidence concerning the role of the intestinal bacteriome in the pathogenesis and disease course of bronchial asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea. Furthermore, we discuss the consequences of an altered gut bacteriome on the most common comorbidities of these lung diseases. Lastly, we also reflect on the therapeutic potential of influencing the gut microbiome to improve disease outcomes. MDPI 2022-12-13 /pmc/articles/PMC9781820/ /pubmed/36557710 http://dx.doi.org/10.3390/microorganisms10122457 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bikov, Andras
Dragonieri, Silvano
Csoma, Balazs
Mazzuca, Carmen
Finamore, Panaiotis
Rocchi, Giulia
Putignani, Lorenza
Guarino, Michele
Scarlata, Simone
The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea
title The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea
title_full The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea
title_fullStr The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea
title_full_unstemmed The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea
title_short The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea
title_sort role of gut bacteriome in asthma, chronic obstructive pulmonary disease and obstructive sleep apnoea
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781820/
https://www.ncbi.nlm.nih.gov/pubmed/36557710
http://dx.doi.org/10.3390/microorganisms10122457
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