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Comparison of Retinal Imaging Techniques in Individuals with Pulmonary Artery Hypertension Using Vessel Generation Analysis
(1) Background: Retinal vascular imaging plays an essential role in diagnosing and managing chronic diseases such as diabetic retinopathy, sickle cell retinopathy, and systemic hypertension. Previously, we have shown that individuals with pulmonary arterial hypertension (PAH), a rare disorder, exhib...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781977/ https://www.ncbi.nlm.nih.gov/pubmed/36556350 http://dx.doi.org/10.3390/life12121985 |
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author | DuPont, Mariana Hunsicker, John Shirley, Simona Warriner, William Rowland, Annabelle Taylor, Reddhyia DuPont, Michael Lagatuz, Mark Yilmaz, Taygan Foderaro, Andrew Lahm, Tim Ventetuolo, Corey E. Grant, Maria B. |
author_facet | DuPont, Mariana Hunsicker, John Shirley, Simona Warriner, William Rowland, Annabelle Taylor, Reddhyia DuPont, Michael Lagatuz, Mark Yilmaz, Taygan Foderaro, Andrew Lahm, Tim Ventetuolo, Corey E. Grant, Maria B. |
author_sort | DuPont, Mariana |
collection | PubMed |
description | (1) Background: Retinal vascular imaging plays an essential role in diagnosing and managing chronic diseases such as diabetic retinopathy, sickle cell retinopathy, and systemic hypertension. Previously, we have shown that individuals with pulmonary arterial hypertension (PAH), a rare disorder, exhibit unique retinal vascular changes as seen using fluorescein angiography (FA) and that these changes correlate with PAH severity. This study aimed to determine if color fundus (CF) imaging could garner identical retinal information as previously seen using FA images in individuals with PAH. (2) Methods: VESGEN, computer software which provides detailed vascular patterns, was used to compare manual segmentations of FA to CF imaging in PAH subjects (n = 9) followed by deep learning (DL) processing of CF imaging to increase the speed of analysis and facilitate a noninvasive clinical translation. (3) Results: When manual segmentation of FA and CF images were compared using VESGEN analysis, both showed identical tortuosity and vessel area density measures. This remained true even when separating images based on arterial trees only. However, this was not observed with microvessels. DL segmentation when compared to manual segmentation of CF images showed similarities in vascular structure as defined by fractal dimension. Similarities were lost for tortuosity and vessel area density when comparing manual CF imaging to DL imaging. (4) Conclusions: Noninvasive imaging such as CF can be used with VESGEN to provide an accurate and safe assessment of retinal vascular changes in individuals with PAH. In addition to providing insight into possible future clinical translational use. |
format | Online Article Text |
id | pubmed-9781977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97819772022-12-24 Comparison of Retinal Imaging Techniques in Individuals with Pulmonary Artery Hypertension Using Vessel Generation Analysis DuPont, Mariana Hunsicker, John Shirley, Simona Warriner, William Rowland, Annabelle Taylor, Reddhyia DuPont, Michael Lagatuz, Mark Yilmaz, Taygan Foderaro, Andrew Lahm, Tim Ventetuolo, Corey E. Grant, Maria B. Life (Basel) Article (1) Background: Retinal vascular imaging plays an essential role in diagnosing and managing chronic diseases such as diabetic retinopathy, sickle cell retinopathy, and systemic hypertension. Previously, we have shown that individuals with pulmonary arterial hypertension (PAH), a rare disorder, exhibit unique retinal vascular changes as seen using fluorescein angiography (FA) and that these changes correlate with PAH severity. This study aimed to determine if color fundus (CF) imaging could garner identical retinal information as previously seen using FA images in individuals with PAH. (2) Methods: VESGEN, computer software which provides detailed vascular patterns, was used to compare manual segmentations of FA to CF imaging in PAH subjects (n = 9) followed by deep learning (DL) processing of CF imaging to increase the speed of analysis and facilitate a noninvasive clinical translation. (3) Results: When manual segmentation of FA and CF images were compared using VESGEN analysis, both showed identical tortuosity and vessel area density measures. This remained true even when separating images based on arterial trees only. However, this was not observed with microvessels. DL segmentation when compared to manual segmentation of CF images showed similarities in vascular structure as defined by fractal dimension. Similarities were lost for tortuosity and vessel area density when comparing manual CF imaging to DL imaging. (4) Conclusions: Noninvasive imaging such as CF can be used with VESGEN to provide an accurate and safe assessment of retinal vascular changes in individuals with PAH. In addition to providing insight into possible future clinical translational use. MDPI 2022-11-28 /pmc/articles/PMC9781977/ /pubmed/36556350 http://dx.doi.org/10.3390/life12121985 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article DuPont, Mariana Hunsicker, John Shirley, Simona Warriner, William Rowland, Annabelle Taylor, Reddhyia DuPont, Michael Lagatuz, Mark Yilmaz, Taygan Foderaro, Andrew Lahm, Tim Ventetuolo, Corey E. Grant, Maria B. Comparison of Retinal Imaging Techniques in Individuals with Pulmonary Artery Hypertension Using Vessel Generation Analysis |
title | Comparison of Retinal Imaging Techniques in Individuals with Pulmonary Artery Hypertension Using Vessel Generation Analysis |
title_full | Comparison of Retinal Imaging Techniques in Individuals with Pulmonary Artery Hypertension Using Vessel Generation Analysis |
title_fullStr | Comparison of Retinal Imaging Techniques in Individuals with Pulmonary Artery Hypertension Using Vessel Generation Analysis |
title_full_unstemmed | Comparison of Retinal Imaging Techniques in Individuals with Pulmonary Artery Hypertension Using Vessel Generation Analysis |
title_short | Comparison of Retinal Imaging Techniques in Individuals with Pulmonary Artery Hypertension Using Vessel Generation Analysis |
title_sort | comparison of retinal imaging techniques in individuals with pulmonary artery hypertension using vessel generation analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781977/ https://www.ncbi.nlm.nih.gov/pubmed/36556350 http://dx.doi.org/10.3390/life12121985 |
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