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Gingerol, a Natural Antioxidant, Attenuates Hyperglycemia and Downstream Complications

Hyperglycemia is seen in approximately 68 percent of patients admitted to a medical intensive care unit (ICU). In many acute circumstances, such as myocardial infarction, brain, injury and stroke, it is an independent predictor of mortality. Hyperglycemia is induced by a mix of genetic, environmenta...

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Autores principales: Alharbi, Khalid Saad, Nadeem, Muhammad Shahid, Afzal, Obaid, Alzarea, Sami I., Altamimi, Abdulmalik S. A., Almalki, Waleed Hassan, Mubeen, Bismillah, Iftikhar, Saima, Shah, Luqman, Kazmi, Imran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782005/
https://www.ncbi.nlm.nih.gov/pubmed/36557312
http://dx.doi.org/10.3390/metabo12121274
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author Alharbi, Khalid Saad
Nadeem, Muhammad Shahid
Afzal, Obaid
Alzarea, Sami I.
Altamimi, Abdulmalik S. A.
Almalki, Waleed Hassan
Mubeen, Bismillah
Iftikhar, Saima
Shah, Luqman
Kazmi, Imran
author_facet Alharbi, Khalid Saad
Nadeem, Muhammad Shahid
Afzal, Obaid
Alzarea, Sami I.
Altamimi, Abdulmalik S. A.
Almalki, Waleed Hassan
Mubeen, Bismillah
Iftikhar, Saima
Shah, Luqman
Kazmi, Imran
author_sort Alharbi, Khalid Saad
collection PubMed
description Hyperglycemia is seen in approximately 68 percent of patients admitted to a medical intensive care unit (ICU). In many acute circumstances, such as myocardial infarction, brain, injury and stroke, it is an independent predictor of mortality. Hyperglycemia is induced by a mix of genetic, environmental, and immunologic variables in people with type 1 diabetes. These factors cause pancreatic beta cell death and insulin insufficiency. Insulin resistance and irregular insulin production cause hyperglycemia in type 2 diabetes patients. Hyperglycemia activates a number of complicated interconnected metabolic processes. Hyperglycemia is a major contributor to the onset and progression of diabetes’ secondary complications such as neuropathy, nephropathy, retinopathy, cataracts, periodontitis, and bone and joint issues. Studies on the health benefits of ginger and its constituent’s impact on hyperglycemia and related disorders have been conducted and gingerol proved to be a potential pharmaceutically active constituent of ginger (Zingiber officinale) that has been shown to lower blood sugar levels, because it possesses antioxidant properties and it functions as an antioxidant in the complicated biochemical process that causes hyperglycemia to be activated. Gingerol not only helps in treating hyperglycemia but also shows effectivity against diseases related to it, such as cardiopathy, kidney failure, vision impairments, bone and joint problems, and teeth and gum infections. Moreover, fresh ginger has various gingerol analogues, with 6-gingerol being the most abundant. However, it is necessary to investigate the efficacy of its other analogues against hyperglycemia and associated disorders at various concentrations in order to determine the appropriate dose for treating these conditions.
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spelling pubmed-97820052022-12-24 Gingerol, a Natural Antioxidant, Attenuates Hyperglycemia and Downstream Complications Alharbi, Khalid Saad Nadeem, Muhammad Shahid Afzal, Obaid Alzarea, Sami I. Altamimi, Abdulmalik S. A. Almalki, Waleed Hassan Mubeen, Bismillah Iftikhar, Saima Shah, Luqman Kazmi, Imran Metabolites Review Hyperglycemia is seen in approximately 68 percent of patients admitted to a medical intensive care unit (ICU). In many acute circumstances, such as myocardial infarction, brain, injury and stroke, it is an independent predictor of mortality. Hyperglycemia is induced by a mix of genetic, environmental, and immunologic variables in people with type 1 diabetes. These factors cause pancreatic beta cell death and insulin insufficiency. Insulin resistance and irregular insulin production cause hyperglycemia in type 2 diabetes patients. Hyperglycemia activates a number of complicated interconnected metabolic processes. Hyperglycemia is a major contributor to the onset and progression of diabetes’ secondary complications such as neuropathy, nephropathy, retinopathy, cataracts, periodontitis, and bone and joint issues. Studies on the health benefits of ginger and its constituent’s impact on hyperglycemia and related disorders have been conducted and gingerol proved to be a potential pharmaceutically active constituent of ginger (Zingiber officinale) that has been shown to lower blood sugar levels, because it possesses antioxidant properties and it functions as an antioxidant in the complicated biochemical process that causes hyperglycemia to be activated. Gingerol not only helps in treating hyperglycemia but also shows effectivity against diseases related to it, such as cardiopathy, kidney failure, vision impairments, bone and joint problems, and teeth and gum infections. Moreover, fresh ginger has various gingerol analogues, with 6-gingerol being the most abundant. However, it is necessary to investigate the efficacy of its other analogues against hyperglycemia and associated disorders at various concentrations in order to determine the appropriate dose for treating these conditions. MDPI 2022-12-16 /pmc/articles/PMC9782005/ /pubmed/36557312 http://dx.doi.org/10.3390/metabo12121274 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alharbi, Khalid Saad
Nadeem, Muhammad Shahid
Afzal, Obaid
Alzarea, Sami I.
Altamimi, Abdulmalik S. A.
Almalki, Waleed Hassan
Mubeen, Bismillah
Iftikhar, Saima
Shah, Luqman
Kazmi, Imran
Gingerol, a Natural Antioxidant, Attenuates Hyperglycemia and Downstream Complications
title Gingerol, a Natural Antioxidant, Attenuates Hyperglycemia and Downstream Complications
title_full Gingerol, a Natural Antioxidant, Attenuates Hyperglycemia and Downstream Complications
title_fullStr Gingerol, a Natural Antioxidant, Attenuates Hyperglycemia and Downstream Complications
title_full_unstemmed Gingerol, a Natural Antioxidant, Attenuates Hyperglycemia and Downstream Complications
title_short Gingerol, a Natural Antioxidant, Attenuates Hyperglycemia and Downstream Complications
title_sort gingerol, a natural antioxidant, attenuates hyperglycemia and downstream complications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782005/
https://www.ncbi.nlm.nih.gov/pubmed/36557312
http://dx.doi.org/10.3390/metabo12121274
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