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Childhood-Onset GH Deficiency versus Adult-Onset GH Deficiency: Relevant Differences Regarding Insulin Sensitivity

The results of the studies on the pattern of insulin sensitivity (IS) are contradictory in patients with GH deficiency (GHD); however, the interference of the GHD onset stage, childhood or adulthood in the IS has not been assessed by euglycemic hyperinsulinemic clamp (EHC), a gold-standard method fo...

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Autores principales: Garmes, Heraldo Mendes, Castillo, Alejandro Rosell, Monte Alegre, Sarah, de Souza, Aglecio Luiz, Atala, Yeelen Ballesteros, Zantut-Wittmann, Denise Engelbrecht
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782045/
https://www.ncbi.nlm.nih.gov/pubmed/36557289
http://dx.doi.org/10.3390/metabo12121251
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author Garmes, Heraldo Mendes
Castillo, Alejandro Rosell
Monte Alegre, Sarah
de Souza, Aglecio Luiz
Atala, Yeelen Ballesteros
Zantut-Wittmann, Denise Engelbrecht
author_facet Garmes, Heraldo Mendes
Castillo, Alejandro Rosell
Monte Alegre, Sarah
de Souza, Aglecio Luiz
Atala, Yeelen Ballesteros
Zantut-Wittmann, Denise Engelbrecht
author_sort Garmes, Heraldo Mendes
collection PubMed
description The results of the studies on the pattern of insulin sensitivity (IS) are contradictory in patients with GH deficiency (GHD); however, the interference of the GHD onset stage, childhood or adulthood in the IS has not been assessed by euglycemic hyperinsulinemic clamp (EHC), a gold-standard method for the assessment of insulin sensitivity. In a prospective cross-sectional study, we assessed IS and body composition in 17 adults with hypopituitarism without GH replacement, ten with childhood-onset (COGHD) and seven with adulthood-onset (AOGHD) and compared them to paired control groups. COGHD presented higher IS (p = 0.0395) and a similar percentage of fat mass (PFM) to AOGHD. COGHD showed higher IS than the control group (0.0235), despite a higher PFM (0.0022). No differences were found between AODGH and the control group. In AOGHD and the control group, IS was negatively correlated with PFM (rs: −0.8214, p = 0.0234 and rs: −0.3639, p < 0.0344), while this correlation was not observed with COGHD (rs: −0.1152, p = 0.7514). Despite the higher PFM, patients with COGHD were more sensitive to insulin than paired healthy individuals, while patients with AOGHD showed similar IS compared to controls. The lack of GH early in life could modify the metabolic characteristics of tissues related to the glucose metabolism, inducing beneficial effects on IS that persist into adulthood. Thus, the glycometabolic findings in patients with COGHD seems to be not applicable to AOGHD.
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spelling pubmed-97820452022-12-24 Childhood-Onset GH Deficiency versus Adult-Onset GH Deficiency: Relevant Differences Regarding Insulin Sensitivity Garmes, Heraldo Mendes Castillo, Alejandro Rosell Monte Alegre, Sarah de Souza, Aglecio Luiz Atala, Yeelen Ballesteros Zantut-Wittmann, Denise Engelbrecht Metabolites Article The results of the studies on the pattern of insulin sensitivity (IS) are contradictory in patients with GH deficiency (GHD); however, the interference of the GHD onset stage, childhood or adulthood in the IS has not been assessed by euglycemic hyperinsulinemic clamp (EHC), a gold-standard method for the assessment of insulin sensitivity. In a prospective cross-sectional study, we assessed IS and body composition in 17 adults with hypopituitarism without GH replacement, ten with childhood-onset (COGHD) and seven with adulthood-onset (AOGHD) and compared them to paired control groups. COGHD presented higher IS (p = 0.0395) and a similar percentage of fat mass (PFM) to AOGHD. COGHD showed higher IS than the control group (0.0235), despite a higher PFM (0.0022). No differences were found between AODGH and the control group. In AOGHD and the control group, IS was negatively correlated with PFM (rs: −0.8214, p = 0.0234 and rs: −0.3639, p < 0.0344), while this correlation was not observed with COGHD (rs: −0.1152, p = 0.7514). Despite the higher PFM, patients with COGHD were more sensitive to insulin than paired healthy individuals, while patients with AOGHD showed similar IS compared to controls. The lack of GH early in life could modify the metabolic characteristics of tissues related to the glucose metabolism, inducing beneficial effects on IS that persist into adulthood. Thus, the glycometabolic findings in patients with COGHD seems to be not applicable to AOGHD. MDPI 2022-12-11 /pmc/articles/PMC9782045/ /pubmed/36557289 http://dx.doi.org/10.3390/metabo12121251 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Garmes, Heraldo Mendes
Castillo, Alejandro Rosell
Monte Alegre, Sarah
de Souza, Aglecio Luiz
Atala, Yeelen Ballesteros
Zantut-Wittmann, Denise Engelbrecht
Childhood-Onset GH Deficiency versus Adult-Onset GH Deficiency: Relevant Differences Regarding Insulin Sensitivity
title Childhood-Onset GH Deficiency versus Adult-Onset GH Deficiency: Relevant Differences Regarding Insulin Sensitivity
title_full Childhood-Onset GH Deficiency versus Adult-Onset GH Deficiency: Relevant Differences Regarding Insulin Sensitivity
title_fullStr Childhood-Onset GH Deficiency versus Adult-Onset GH Deficiency: Relevant Differences Regarding Insulin Sensitivity
title_full_unstemmed Childhood-Onset GH Deficiency versus Adult-Onset GH Deficiency: Relevant Differences Regarding Insulin Sensitivity
title_short Childhood-Onset GH Deficiency versus Adult-Onset GH Deficiency: Relevant Differences Regarding Insulin Sensitivity
title_sort childhood-onset gh deficiency versus adult-onset gh deficiency: relevant differences regarding insulin sensitivity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782045/
https://www.ncbi.nlm.nih.gov/pubmed/36557289
http://dx.doi.org/10.3390/metabo12121251
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