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Waning of Humoral Immunity and the Influencing Factors after BNT162b2 Vaccination: A Cohort Study with a Latent Growth Curve Model in Fukushima

Measuring long-term antibody titer kinetics and subsequent coronavirus disease 2019 (COVID-19) vaccinations are crucial for identifying vulnerable populations. Our aim was to determine the association between long-term antibody kinetics, including peak titers and factors, up to seven months post-sec...

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Autores principales: Kobashi, Yurie, Takebayashi, Yoshitake, Yoshida, Makoto, Kawamura, Takeshi, Shimazu, Yuzo, Kaneko, Yudai, Nishikawa, Yoshitaka, Nakayama, Aya, Takita, Morihito, Zhao, Tianchen, Yamamoto, Chika, Ito, Naomi, Tsubokura, Masaharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782062/
https://www.ncbi.nlm.nih.gov/pubmed/36560417
http://dx.doi.org/10.3390/vaccines10122007
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author Kobashi, Yurie
Takebayashi, Yoshitake
Yoshida, Makoto
Kawamura, Takeshi
Shimazu, Yuzo
Kaneko, Yudai
Nishikawa, Yoshitaka
Nakayama, Aya
Takita, Morihito
Zhao, Tianchen
Yamamoto, Chika
Ito, Naomi
Tsubokura, Masaharu
author_facet Kobashi, Yurie
Takebayashi, Yoshitake
Yoshida, Makoto
Kawamura, Takeshi
Shimazu, Yuzo
Kaneko, Yudai
Nishikawa, Yoshitaka
Nakayama, Aya
Takita, Morihito
Zhao, Tianchen
Yamamoto, Chika
Ito, Naomi
Tsubokura, Masaharu
author_sort Kobashi, Yurie
collection PubMed
description Measuring long-term antibody titer kinetics and subsequent coronavirus disease 2019 (COVID-19) vaccinations are crucial for identifying vulnerable populations. Our aim was to determine the association between long-term antibody kinetics, including peak titers and factors, up to seven months post-second vaccination. A three-time antibody survey was conducted in 2021 among healthcare workers in Japan to investigate the changes in humoral immunity using chemiluminescence immunoassay. The study involved 205 participants who had received the second vaccine dose, completed the three-time survey, and were not infected with SARS-CoV-2. A latent growth curve model was used to identify factors affecting the peak titer and decreasing the antibody slope. Of the eligible participants, the mean titers of immunoglobulin G (IgG) against the spike (S) protein and the neutralizing activity 7 months after the second vaccination decreased to 154.3 (8.8% of the peak titer) and 62.1 AU/mL (9.5% of the peak titer), respectively. The IgG growth model showed that age significantly affected peak titers (p < 0.001); however, a significant difference was not found for the decreasing slope. Ultimately, aging adults had significantly low peak antibody titers; however, age was unrelated to the slope of log-transformed IgG against the S protein.
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spelling pubmed-97820622022-12-24 Waning of Humoral Immunity and the Influencing Factors after BNT162b2 Vaccination: A Cohort Study with a Latent Growth Curve Model in Fukushima Kobashi, Yurie Takebayashi, Yoshitake Yoshida, Makoto Kawamura, Takeshi Shimazu, Yuzo Kaneko, Yudai Nishikawa, Yoshitaka Nakayama, Aya Takita, Morihito Zhao, Tianchen Yamamoto, Chika Ito, Naomi Tsubokura, Masaharu Vaccines (Basel) Article Measuring long-term antibody titer kinetics and subsequent coronavirus disease 2019 (COVID-19) vaccinations are crucial for identifying vulnerable populations. Our aim was to determine the association between long-term antibody kinetics, including peak titers and factors, up to seven months post-second vaccination. A three-time antibody survey was conducted in 2021 among healthcare workers in Japan to investigate the changes in humoral immunity using chemiluminescence immunoassay. The study involved 205 participants who had received the second vaccine dose, completed the three-time survey, and were not infected with SARS-CoV-2. A latent growth curve model was used to identify factors affecting the peak titer and decreasing the antibody slope. Of the eligible participants, the mean titers of immunoglobulin G (IgG) against the spike (S) protein and the neutralizing activity 7 months after the second vaccination decreased to 154.3 (8.8% of the peak titer) and 62.1 AU/mL (9.5% of the peak titer), respectively. The IgG growth model showed that age significantly affected peak titers (p < 0.001); however, a significant difference was not found for the decreasing slope. Ultimately, aging adults had significantly low peak antibody titers; however, age was unrelated to the slope of log-transformed IgG against the S protein. MDPI 2022-11-25 /pmc/articles/PMC9782062/ /pubmed/36560417 http://dx.doi.org/10.3390/vaccines10122007 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kobashi, Yurie
Takebayashi, Yoshitake
Yoshida, Makoto
Kawamura, Takeshi
Shimazu, Yuzo
Kaneko, Yudai
Nishikawa, Yoshitaka
Nakayama, Aya
Takita, Morihito
Zhao, Tianchen
Yamamoto, Chika
Ito, Naomi
Tsubokura, Masaharu
Waning of Humoral Immunity and the Influencing Factors after BNT162b2 Vaccination: A Cohort Study with a Latent Growth Curve Model in Fukushima
title Waning of Humoral Immunity and the Influencing Factors after BNT162b2 Vaccination: A Cohort Study with a Latent Growth Curve Model in Fukushima
title_full Waning of Humoral Immunity and the Influencing Factors after BNT162b2 Vaccination: A Cohort Study with a Latent Growth Curve Model in Fukushima
title_fullStr Waning of Humoral Immunity and the Influencing Factors after BNT162b2 Vaccination: A Cohort Study with a Latent Growth Curve Model in Fukushima
title_full_unstemmed Waning of Humoral Immunity and the Influencing Factors after BNT162b2 Vaccination: A Cohort Study with a Latent Growth Curve Model in Fukushima
title_short Waning of Humoral Immunity and the Influencing Factors after BNT162b2 Vaccination: A Cohort Study with a Latent Growth Curve Model in Fukushima
title_sort waning of humoral immunity and the influencing factors after bnt162b2 vaccination: a cohort study with a latent growth curve model in fukushima
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782062/
https://www.ncbi.nlm.nih.gov/pubmed/36560417
http://dx.doi.org/10.3390/vaccines10122007
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