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Correlation between 25-hydroxyvitamin D/D3 Deficiency and COVID-19 Disease Severity in Adults from Northern Colorado

Vitamin D deficiency is common in the United States and leads to altered immune function, including T cell and macrophage activity that may impact responses to SARS-CoV-2 infection. This study investigated 131 adults with a history of a positive SARS-CoV-2 nasopharyngeal PCR and 18 adults with no CO...

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Autores principales: Baxter, Bridget A., Ryan, Michaela G., LaVergne, Stephanie M., Stromberg, Sophia, Berry, Kailey, Tipton, Madison, Natter, Nicole, Nudell, Nikiah, McFann, Kim, Dunn, Julie, Webb, Tracy L., Armstrong, Michael, Reisdorph, Nichole, Ryan, Elizabeth P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782165/
https://www.ncbi.nlm.nih.gov/pubmed/36558362
http://dx.doi.org/10.3390/nu14245204
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author Baxter, Bridget A.
Ryan, Michaela G.
LaVergne, Stephanie M.
Stromberg, Sophia
Berry, Kailey
Tipton, Madison
Natter, Nicole
Nudell, Nikiah
McFann, Kim
Dunn, Julie
Webb, Tracy L.
Armstrong, Michael
Reisdorph, Nichole
Ryan, Elizabeth P.
author_facet Baxter, Bridget A.
Ryan, Michaela G.
LaVergne, Stephanie M.
Stromberg, Sophia
Berry, Kailey
Tipton, Madison
Natter, Nicole
Nudell, Nikiah
McFann, Kim
Dunn, Julie
Webb, Tracy L.
Armstrong, Michael
Reisdorph, Nichole
Ryan, Elizabeth P.
author_sort Baxter, Bridget A.
collection PubMed
description Vitamin D deficiency is common in the United States and leads to altered immune function, including T cell and macrophage activity that may impact responses to SARS-CoV-2 infection. This study investigated 131 adults with a history of a positive SARS-CoV-2 nasopharyngeal PCR and 18 adults with no COVID-19 diagnosis that were recruited from the community or hospital into the Northern Colorado Coronavirus Biorepository (NoCo-COBIO). Participants consented to enrollment for a period of 6 months and provided biospecimens at multiple visits for longitudinal analysis. Plasma 25-hydroxyvitamin D levels were quantified by LC-MS/MS at the initial visit (n = 149) and after 4 months (n = 89). Adults were classified as deficient (<30 nM or <12 ng/mL), insufficient (<30–50 nM or 12–20 ng/mL), or optimal (50–75 nM or >20 ng/mL) for 25-hydroxyvitamin D status. Fisher’s exact test demonstrated an association between disease severity, gender, and body mass index (BMI) at baseline. Mixed model analyses with Tukey-Kramer were used for longitudinal analysis according to BMI. Sixty-nine percent (n = 103) of the entire cohort had optimal levels of total 25(OH)D, 22% (n = 32) had insufficient levels, and 9% (n = 14) had deficent levels. Participants with severe disease (n = 37) had significantly lower 25-hydroxyvitamin D (total 25(OH)D) when compared to adults with mild disease (p = 0.006) or no COVID-19 diagnosis (p = 0.007). There was 44% of the cohort with post-acute sequalae of COVID-19 (PASC) as defined by experiencing at least one of the following symptoms after 60 days’ post-infection: fatigue, dyspnea, joint pain, chest pain, forgetfulness or absent-mindedness, confusion, or difficulty breathing. While significant differences were detected in 25-hydroxyvitamin D status by sex and BMI, there were no correlations between 25-hydroxyvitamin D for those without and without PASC. This longitudinal study of COVID-19 survivors demonstrates an important association between sex, BMI, and disease severity for 25-hydroxyvitamin D deficiency during acute stages of infection, yet it is not clear whether supplementation efforts would influence long term outcomes such as developing PASC.
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spelling pubmed-97821652022-12-24 Correlation between 25-hydroxyvitamin D/D3 Deficiency and COVID-19 Disease Severity in Adults from Northern Colorado Baxter, Bridget A. Ryan, Michaela G. LaVergne, Stephanie M. Stromberg, Sophia Berry, Kailey Tipton, Madison Natter, Nicole Nudell, Nikiah McFann, Kim Dunn, Julie Webb, Tracy L. Armstrong, Michael Reisdorph, Nichole Ryan, Elizabeth P. Nutrients Article Vitamin D deficiency is common in the United States and leads to altered immune function, including T cell and macrophage activity that may impact responses to SARS-CoV-2 infection. This study investigated 131 adults with a history of a positive SARS-CoV-2 nasopharyngeal PCR and 18 adults with no COVID-19 diagnosis that were recruited from the community or hospital into the Northern Colorado Coronavirus Biorepository (NoCo-COBIO). Participants consented to enrollment for a period of 6 months and provided biospecimens at multiple visits for longitudinal analysis. Plasma 25-hydroxyvitamin D levels were quantified by LC-MS/MS at the initial visit (n = 149) and after 4 months (n = 89). Adults were classified as deficient (<30 nM or <12 ng/mL), insufficient (<30–50 nM or 12–20 ng/mL), or optimal (50–75 nM or >20 ng/mL) for 25-hydroxyvitamin D status. Fisher’s exact test demonstrated an association between disease severity, gender, and body mass index (BMI) at baseline. Mixed model analyses with Tukey-Kramer were used for longitudinal analysis according to BMI. Sixty-nine percent (n = 103) of the entire cohort had optimal levels of total 25(OH)D, 22% (n = 32) had insufficient levels, and 9% (n = 14) had deficent levels. Participants with severe disease (n = 37) had significantly lower 25-hydroxyvitamin D (total 25(OH)D) when compared to adults with mild disease (p = 0.006) or no COVID-19 diagnosis (p = 0.007). There was 44% of the cohort with post-acute sequalae of COVID-19 (PASC) as defined by experiencing at least one of the following symptoms after 60 days’ post-infection: fatigue, dyspnea, joint pain, chest pain, forgetfulness or absent-mindedness, confusion, or difficulty breathing. While significant differences were detected in 25-hydroxyvitamin D status by sex and BMI, there were no correlations between 25-hydroxyvitamin D for those without and without PASC. This longitudinal study of COVID-19 survivors demonstrates an important association between sex, BMI, and disease severity for 25-hydroxyvitamin D deficiency during acute stages of infection, yet it is not clear whether supplementation efforts would influence long term outcomes such as developing PASC. MDPI 2022-12-07 /pmc/articles/PMC9782165/ /pubmed/36558362 http://dx.doi.org/10.3390/nu14245204 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baxter, Bridget A.
Ryan, Michaela G.
LaVergne, Stephanie M.
Stromberg, Sophia
Berry, Kailey
Tipton, Madison
Natter, Nicole
Nudell, Nikiah
McFann, Kim
Dunn, Julie
Webb, Tracy L.
Armstrong, Michael
Reisdorph, Nichole
Ryan, Elizabeth P.
Correlation between 25-hydroxyvitamin D/D3 Deficiency and COVID-19 Disease Severity in Adults from Northern Colorado
title Correlation between 25-hydroxyvitamin D/D3 Deficiency and COVID-19 Disease Severity in Adults from Northern Colorado
title_full Correlation between 25-hydroxyvitamin D/D3 Deficiency and COVID-19 Disease Severity in Adults from Northern Colorado
title_fullStr Correlation between 25-hydroxyvitamin D/D3 Deficiency and COVID-19 Disease Severity in Adults from Northern Colorado
title_full_unstemmed Correlation between 25-hydroxyvitamin D/D3 Deficiency and COVID-19 Disease Severity in Adults from Northern Colorado
title_short Correlation between 25-hydroxyvitamin D/D3 Deficiency and COVID-19 Disease Severity in Adults from Northern Colorado
title_sort correlation between 25-hydroxyvitamin d/d3 deficiency and covid-19 disease severity in adults from northern colorado
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782165/
https://www.ncbi.nlm.nih.gov/pubmed/36558362
http://dx.doi.org/10.3390/nu14245204
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