The Colombian Zika Virus Isolate (COL345Si) Replicates in Prostate Adenocarcinoma Cells and Modulates the Antiviral Response

Zika virus (ZIKV), a flavivirus that is mainly transmitted by A. aegypti and A. albopictus and sexual transmission, has been documented and described. The ZIKV RNA detection in the semen of vasectomized men indicates that accessory glands such as the prostate could be a site of virus replication. In...

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Autores principales: Miranda Brand, Yaneth, Bedoya, Astrid M., Betancur-Galvis, Liliana, Gallego-Gómez, Juan Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782197/
https://www.ncbi.nlm.nih.gov/pubmed/36557673
http://dx.doi.org/10.3390/microorganisms10122420
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author Miranda Brand, Yaneth
Bedoya, Astrid M.
Betancur-Galvis, Liliana
Gallego-Gómez, Juan Carlos
author_facet Miranda Brand, Yaneth
Bedoya, Astrid M.
Betancur-Galvis, Liliana
Gallego-Gómez, Juan Carlos
author_sort Miranda Brand, Yaneth
collection PubMed
description Zika virus (ZIKV), a flavivirus that is mainly transmitted by A. aegypti and A. albopictus and sexual transmission, has been documented and described. The ZIKV RNA detection in the semen of vasectomized men indicates that accessory glands such as the prostate could be a site of virus replication. In this study, we characterized the ZIKV infection, evaluated the antiviral profile, and demonstrated the AXL and TIM-1 expression on the PC3 prostate cell line. It was also determined that PC3 cells are susceptible and permissive to ZIKV infection without altering the cell viability or causing a cytopathic effect. The antiviral profile suggests that the PC3 cells modulate the antiviral response through the suppressor molecule expression, SOCS-1, during a ZIKV infection.
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spelling pubmed-97821972022-12-24 The Colombian Zika Virus Isolate (COL345Si) Replicates in Prostate Adenocarcinoma Cells and Modulates the Antiviral Response Miranda Brand, Yaneth Bedoya, Astrid M. Betancur-Galvis, Liliana Gallego-Gómez, Juan Carlos Microorganisms Article Zika virus (ZIKV), a flavivirus that is mainly transmitted by A. aegypti and A. albopictus and sexual transmission, has been documented and described. The ZIKV RNA detection in the semen of vasectomized men indicates that accessory glands such as the prostate could be a site of virus replication. In this study, we characterized the ZIKV infection, evaluated the antiviral profile, and demonstrated the AXL and TIM-1 expression on the PC3 prostate cell line. It was also determined that PC3 cells are susceptible and permissive to ZIKV infection without altering the cell viability or causing a cytopathic effect. The antiviral profile suggests that the PC3 cells modulate the antiviral response through the suppressor molecule expression, SOCS-1, during a ZIKV infection. MDPI 2022-12-07 /pmc/articles/PMC9782197/ /pubmed/36557673 http://dx.doi.org/10.3390/microorganisms10122420 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Miranda Brand, Yaneth
Bedoya, Astrid M.
Betancur-Galvis, Liliana
Gallego-Gómez, Juan Carlos
The Colombian Zika Virus Isolate (COL345Si) Replicates in Prostate Adenocarcinoma Cells and Modulates the Antiviral Response
title The Colombian Zika Virus Isolate (COL345Si) Replicates in Prostate Adenocarcinoma Cells and Modulates the Antiviral Response
title_full The Colombian Zika Virus Isolate (COL345Si) Replicates in Prostate Adenocarcinoma Cells and Modulates the Antiviral Response
title_fullStr The Colombian Zika Virus Isolate (COL345Si) Replicates in Prostate Adenocarcinoma Cells and Modulates the Antiviral Response
title_full_unstemmed The Colombian Zika Virus Isolate (COL345Si) Replicates in Prostate Adenocarcinoma Cells and Modulates the Antiviral Response
title_short The Colombian Zika Virus Isolate (COL345Si) Replicates in Prostate Adenocarcinoma Cells and Modulates the Antiviral Response
title_sort colombian zika virus isolate (col345si) replicates in prostate adenocarcinoma cells and modulates the antiviral response
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782197/
https://www.ncbi.nlm.nih.gov/pubmed/36557673
http://dx.doi.org/10.3390/microorganisms10122420
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