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Tunable Self-Assembled Peptide Hydrogel Sensor for Pharma Cold Supply Chain

[Image: see text] Defrost sensors are a crucial element for proper functioning of the pharmaceutical cold chain. In this paper, the self-assembled peptide-based hydrogels were used to construct a sensitive defrost sensor for the transportation and storage of medications and biomaterials. The turbidi...

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Autores principales: Tikhonova, Tatiana N., Cohen-Gerassi, Dana, Arnon, Zohar A., Efremov, Yuri, Timashev, Peter, Adler-Abramovich, Lihi, Shirshin, Evgeny A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782340/
https://www.ncbi.nlm.nih.gov/pubmed/36475602
http://dx.doi.org/10.1021/acsami.2c17609
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author Tikhonova, Tatiana N.
Cohen-Gerassi, Dana
Arnon, Zohar A.
Efremov, Yuri
Timashev, Peter
Adler-Abramovich, Lihi
Shirshin, Evgeny A.
author_facet Tikhonova, Tatiana N.
Cohen-Gerassi, Dana
Arnon, Zohar A.
Efremov, Yuri
Timashev, Peter
Adler-Abramovich, Lihi
Shirshin, Evgeny A.
author_sort Tikhonova, Tatiana N.
collection PubMed
description [Image: see text] Defrost sensors are a crucial element for proper functioning of the pharmaceutical cold chain. In this paper, the self-assembled peptide-based hydrogels were used to construct a sensitive defrost sensor for the transportation and storage of medications and biomaterials. The turbidity of the peptide hydrogel was employed as a marker of the temperature regime. The gelation kinetics under different conditions was studied to detect various stages of hydrogel structural transitions aimed at tuning the system properties. The developed sensor can be stored at room temperature for a long period, irreversibly indicates whether the product has been thawed, and can be adjusted to a specific temperature range and detection time.
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spelling pubmed-97823402022-12-24 Tunable Self-Assembled Peptide Hydrogel Sensor for Pharma Cold Supply Chain Tikhonova, Tatiana N. Cohen-Gerassi, Dana Arnon, Zohar A. Efremov, Yuri Timashev, Peter Adler-Abramovich, Lihi Shirshin, Evgeny A. ACS Appl Mater Interfaces [Image: see text] Defrost sensors are a crucial element for proper functioning of the pharmaceutical cold chain. In this paper, the self-assembled peptide-based hydrogels were used to construct a sensitive defrost sensor for the transportation and storage of medications and biomaterials. The turbidity of the peptide hydrogel was employed as a marker of the temperature regime. The gelation kinetics under different conditions was studied to detect various stages of hydrogel structural transitions aimed at tuning the system properties. The developed sensor can be stored at room temperature for a long period, irreversibly indicates whether the product has been thawed, and can be adjusted to a specific temperature range and detection time. American Chemical Society 2022-12-08 2022-12-21 /pmc/articles/PMC9782340/ /pubmed/36475602 http://dx.doi.org/10.1021/acsami.2c17609 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Tikhonova, Tatiana N.
Cohen-Gerassi, Dana
Arnon, Zohar A.
Efremov, Yuri
Timashev, Peter
Adler-Abramovich, Lihi
Shirshin, Evgeny A.
Tunable Self-Assembled Peptide Hydrogel Sensor for Pharma Cold Supply Chain
title Tunable Self-Assembled Peptide Hydrogel Sensor for Pharma Cold Supply Chain
title_full Tunable Self-Assembled Peptide Hydrogel Sensor for Pharma Cold Supply Chain
title_fullStr Tunable Self-Assembled Peptide Hydrogel Sensor for Pharma Cold Supply Chain
title_full_unstemmed Tunable Self-Assembled Peptide Hydrogel Sensor for Pharma Cold Supply Chain
title_short Tunable Self-Assembled Peptide Hydrogel Sensor for Pharma Cold Supply Chain
title_sort tunable self-assembled peptide hydrogel sensor for pharma cold supply chain
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782340/
https://www.ncbi.nlm.nih.gov/pubmed/36475602
http://dx.doi.org/10.1021/acsami.2c17609
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