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The Age-Related Course of COVID-19 in Pediatric Patients—1405 Cases in a Single Center

Since the beginning of the pandemic, many reports have pointed to age as the most important risk factor for severe COVID-19 in adults, but this relationship is less clear in children. Between March 2020 and April 2022, 1405 pediatric COVID-19 patients were included in our prospective study, which ai...

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Autores principales: Stopyra, Lidia, Kowalik, Aleksandra, Stala, Justyna, Majchrzak, Ida, Szebla, Justyna, Jakosz, Mateusz, Kwinta, Przemko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782360/
https://www.ncbi.nlm.nih.gov/pubmed/36555963
http://dx.doi.org/10.3390/jcm11247347
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author Stopyra, Lidia
Kowalik, Aleksandra
Stala, Justyna
Majchrzak, Ida
Szebla, Justyna
Jakosz, Mateusz
Kwinta, Przemko
author_facet Stopyra, Lidia
Kowalik, Aleksandra
Stala, Justyna
Majchrzak, Ida
Szebla, Justyna
Jakosz, Mateusz
Kwinta, Przemko
author_sort Stopyra, Lidia
collection PubMed
description Since the beginning of the pandemic, many reports have pointed to age as the most important risk factor for severe COVID-19 in adults, but this relationship is less clear in children. Between March 2020 and April 2022, 1405 pediatric COVID-19 patients were included in our prospective study, which aimed to analyze the disease’s characteristics in three age groups: infants, toddlers (1–5 years), and children (5–18 years). We observed male prevalence of the disease in infants and toddlers compared to female prevalence in children. Comorbidities appeared most often in children. In the first pandemic wave, the vast majority of pediatric patients were children, but later, the percentage of infant and toddler patients increased significantly. A total of 74% of hospitalized children were younger than five years. Upper respiratory tract symptoms were most common in infants and toddlers, and lower respiratory tract symptoms and gastroenterocolitis were more common in children. Neurological symptoms appeared similarly in all age groups. The activities of ALT, CK, and LDH were the most elevated in infants, along with D-dimers. The median length of hospitalization fluctuated between three and four days and was highest in infants. Severe courses were more common in adolescents.
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spelling pubmed-97823602022-12-24 The Age-Related Course of COVID-19 in Pediatric Patients—1405 Cases in a Single Center Stopyra, Lidia Kowalik, Aleksandra Stala, Justyna Majchrzak, Ida Szebla, Justyna Jakosz, Mateusz Kwinta, Przemko J Clin Med Article Since the beginning of the pandemic, many reports have pointed to age as the most important risk factor for severe COVID-19 in adults, but this relationship is less clear in children. Between March 2020 and April 2022, 1405 pediatric COVID-19 patients were included in our prospective study, which aimed to analyze the disease’s characteristics in three age groups: infants, toddlers (1–5 years), and children (5–18 years). We observed male prevalence of the disease in infants and toddlers compared to female prevalence in children. Comorbidities appeared most often in children. In the first pandemic wave, the vast majority of pediatric patients were children, but later, the percentage of infant and toddler patients increased significantly. A total of 74% of hospitalized children were younger than five years. Upper respiratory tract symptoms were most common in infants and toddlers, and lower respiratory tract symptoms and gastroenterocolitis were more common in children. Neurological symptoms appeared similarly in all age groups. The activities of ALT, CK, and LDH were the most elevated in infants, along with D-dimers. The median length of hospitalization fluctuated between three and four days and was highest in infants. Severe courses were more common in adolescents. MDPI 2022-12-10 /pmc/articles/PMC9782360/ /pubmed/36555963 http://dx.doi.org/10.3390/jcm11247347 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stopyra, Lidia
Kowalik, Aleksandra
Stala, Justyna
Majchrzak, Ida
Szebla, Justyna
Jakosz, Mateusz
Kwinta, Przemko
The Age-Related Course of COVID-19 in Pediatric Patients—1405 Cases in a Single Center
title The Age-Related Course of COVID-19 in Pediatric Patients—1405 Cases in a Single Center
title_full The Age-Related Course of COVID-19 in Pediatric Patients—1405 Cases in a Single Center
title_fullStr The Age-Related Course of COVID-19 in Pediatric Patients—1405 Cases in a Single Center
title_full_unstemmed The Age-Related Course of COVID-19 in Pediatric Patients—1405 Cases in a Single Center
title_short The Age-Related Course of COVID-19 in Pediatric Patients—1405 Cases in a Single Center
title_sort age-related course of covid-19 in pediatric patients—1405 cases in a single center
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782360/
https://www.ncbi.nlm.nih.gov/pubmed/36555963
http://dx.doi.org/10.3390/jcm11247347
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