The reversible effects of free fatty acids on sulfonylurea-stimulated insulin secretion are related to the expression and dynamin-mediated endocytosis of K(ATP) channels in pancreatic β cells

OBJECTIVE: Lipotoxicity-induced pancreatic β cell-dysfunction results in decreased insulin secretion in response to multiple stimulus. In this study, we investigated the reversible effects of palmitate (PA) or oleate (OA) on insulin secretion and the relationship with pancreatic β-cell ATP-sensitive...

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Detalles Bibliográficos
Autores principales: Wei, Chenmin, Zhang, Zichen, Fu, Qi, He, Yunqiang, Yang, Tao, Sun, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782416/
https://www.ncbi.nlm.nih.gov/pubmed/36398885
http://dx.doi.org/10.1530/EC-22-0221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782416/
https://www.ncbi.nlm.nih.gov/pubmed/36398885
http://dx.doi.org/10.1530/EC-22-0221

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