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Effect of Dupilumab on Sexual Desire in Adult Patients with Moderate to Severe Atopic Dermatitis
Background: Atopic dermatitis (AD) is a chronic inflammatory condition causing itching skin, with a significant psychosocial impact on patients and relatives. AD affects 15 to 30% of children and 2 to 10% of adults. AD significantly affects patients’ quality of life (QoL) given the chronicity and sy...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782472/ https://www.ncbi.nlm.nih.gov/pubmed/36556910 http://dx.doi.org/10.3390/medicina58121708 |
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author | Napolitano, Maddalena Fabbrocini, Gabriella Kastl, Sara Battista, Teresa Di Guida, Adriana Martora, Fabrizio Picone, Vincenzo Ventura, Virginia Patruno, Cataldo |
author_facet | Napolitano, Maddalena Fabbrocini, Gabriella Kastl, Sara Battista, Teresa Di Guida, Adriana Martora, Fabrizio Picone, Vincenzo Ventura, Virginia Patruno, Cataldo |
author_sort | Napolitano, Maddalena |
collection | PubMed |
description | Background: Atopic dermatitis (AD) is a chronic inflammatory condition causing itching skin, with a significant psychosocial impact on patients and relatives. AD affects 15 to 30% of children and 2 to 10% of adults. AD significantly affects patients’ quality of life (QoL) given the chronicity and symptoms of the disease. Most AD patients have reported that the disease affects daily life, resulting in limited social contact and a strong impact on sexual health (SH), especially in moderate–severe cases. Materials and methods: We performed a prospective study from 1 May 2020 to 1 May 2022; the aim of the study was to evaluate the impact of moderate to severe AD on sexual desire, seduction, and partner relationships, and describe how it varies following dupilumab therapy. We used the Sexual Desire Inventory-2 (SDI-2), a validated instrument consisting of 14 items; moreover, we used a second questionnaire with eight items, an unvalidated instrument created specifically for this study, to obtain the assessment of the influence of AD on the body image, sexuality, and self-perception of those affected. Results and Conclusions: The impact of AD on sexual desire assessed using SDI-2 showed a significant improvement in both sexes during dupilumab treatment from the baseline to W4 and W16. Similar results were obtained with our questionnaire. |
format | Online Article Text |
id | pubmed-9782472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97824722022-12-24 Effect of Dupilumab on Sexual Desire in Adult Patients with Moderate to Severe Atopic Dermatitis Napolitano, Maddalena Fabbrocini, Gabriella Kastl, Sara Battista, Teresa Di Guida, Adriana Martora, Fabrizio Picone, Vincenzo Ventura, Virginia Patruno, Cataldo Medicina (Kaunas) Article Background: Atopic dermatitis (AD) is a chronic inflammatory condition causing itching skin, with a significant psychosocial impact on patients and relatives. AD affects 15 to 30% of children and 2 to 10% of adults. AD significantly affects patients’ quality of life (QoL) given the chronicity and symptoms of the disease. Most AD patients have reported that the disease affects daily life, resulting in limited social contact and a strong impact on sexual health (SH), especially in moderate–severe cases. Materials and methods: We performed a prospective study from 1 May 2020 to 1 May 2022; the aim of the study was to evaluate the impact of moderate to severe AD on sexual desire, seduction, and partner relationships, and describe how it varies following dupilumab therapy. We used the Sexual Desire Inventory-2 (SDI-2), a validated instrument consisting of 14 items; moreover, we used a second questionnaire with eight items, an unvalidated instrument created specifically for this study, to obtain the assessment of the influence of AD on the body image, sexuality, and self-perception of those affected. Results and Conclusions: The impact of AD on sexual desire assessed using SDI-2 showed a significant improvement in both sexes during dupilumab treatment from the baseline to W4 and W16. Similar results were obtained with our questionnaire. MDPI 2022-11-23 /pmc/articles/PMC9782472/ /pubmed/36556910 http://dx.doi.org/10.3390/medicina58121708 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Napolitano, Maddalena Fabbrocini, Gabriella Kastl, Sara Battista, Teresa Di Guida, Adriana Martora, Fabrizio Picone, Vincenzo Ventura, Virginia Patruno, Cataldo Effect of Dupilumab on Sexual Desire in Adult Patients with Moderate to Severe Atopic Dermatitis |
title | Effect of Dupilumab on Sexual Desire in Adult Patients with Moderate to Severe Atopic Dermatitis |
title_full | Effect of Dupilumab on Sexual Desire in Adult Patients with Moderate to Severe Atopic Dermatitis |
title_fullStr | Effect of Dupilumab on Sexual Desire in Adult Patients with Moderate to Severe Atopic Dermatitis |
title_full_unstemmed | Effect of Dupilumab on Sexual Desire in Adult Patients with Moderate to Severe Atopic Dermatitis |
title_short | Effect of Dupilumab on Sexual Desire in Adult Patients with Moderate to Severe Atopic Dermatitis |
title_sort | effect of dupilumab on sexual desire in adult patients with moderate to severe atopic dermatitis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782472/ https://www.ncbi.nlm.nih.gov/pubmed/36556910 http://dx.doi.org/10.3390/medicina58121708 |
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