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Inhibition of Liquid–Liquid Phase Separation for Breaking the Solubility Barrier of Amorphous Solid Dispersions to Improve Oral Absorption of Naftopidil

Amorphous solid dispersion (ASD) is one of the most promising technologies for improving the oral absorption of poorly soluble compounds. In this study, naftopidil (NFT) ASDs were prepared using vinylpyrrolidone-vinyl acetate copolymer (PVPVA), hydroxypropyl methylcellulose acetate succinate (HPMCAS...

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Detalles Bibliográficos
Autores principales:	Fukiage, Masafumi, Suzuki, Kyosuke, Matsuda, Maki, Nishida, Yohei, Oikawa, Michinori, Fujita, Takuya, Kawakami, Kohsaku
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782492/ https://www.ncbi.nlm.nih.gov/pubmed/36559158 http://dx.doi.org/10.3390/pharmaceutics14122664

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