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Vitamin D and Systems Biology

The biological actions of the vitamin D receptor (VDR) have been investigated intensively for over 100 years and has led to the identification of significant insights into the repertoire of its biological actions. These were initially established to be centered on the regulation of calcium transport...

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Autores principales: Hussain, Shahid, Yates, Clayton, Campbell, Moray J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782494/
https://www.ncbi.nlm.nih.gov/pubmed/36558356
http://dx.doi.org/10.3390/nu14245197
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author Hussain, Shahid
Yates, Clayton
Campbell, Moray J.
author_facet Hussain, Shahid
Yates, Clayton
Campbell, Moray J.
author_sort Hussain, Shahid
collection PubMed
description The biological actions of the vitamin D receptor (VDR) have been investigated intensively for over 100 years and has led to the identification of significant insights into the repertoire of its biological actions. These were initially established to be centered on the regulation of calcium transport in the colon and deposition in bone. Beyond these well-known calcemic roles, other roles have emerged in the regulation of cell differentiation processes and have an impact on metabolism. The purpose of the current review is to consider where applying systems biology (SB) approaches may begin to generate a more precise understanding of where the VDR is, and is not, biologically impactful. Two SB approaches have been developed and begun to reveal insight into VDR biological functions. In a top-down SB approach genome-wide scale data are statistically analyzed, and from which a role for the VDR emerges in terms of being a hub in a biological network. Such approaches have confirmed significant roles, for example, in myeloid differentiation and the control of inflammation and innate immunity. In a bottom-up SB approach, current biological understanding is built into a kinetic model which is then applied to existing biological data to explain the function and identify unknown behavior. To date, this has not been applied to the VDR, but has to the related ERα and identified previously unknown mechanisms of control. One arena where applying top-down and bottom-up SB approaches may be informative is in the setting of prostate cancer health disparities.
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spelling pubmed-97824942022-12-24 Vitamin D and Systems Biology Hussain, Shahid Yates, Clayton Campbell, Moray J. Nutrients Review The biological actions of the vitamin D receptor (VDR) have been investigated intensively for over 100 years and has led to the identification of significant insights into the repertoire of its biological actions. These were initially established to be centered on the regulation of calcium transport in the colon and deposition in bone. Beyond these well-known calcemic roles, other roles have emerged in the regulation of cell differentiation processes and have an impact on metabolism. The purpose of the current review is to consider where applying systems biology (SB) approaches may begin to generate a more precise understanding of where the VDR is, and is not, biologically impactful. Two SB approaches have been developed and begun to reveal insight into VDR biological functions. In a top-down SB approach genome-wide scale data are statistically analyzed, and from which a role for the VDR emerges in terms of being a hub in a biological network. Such approaches have confirmed significant roles, for example, in myeloid differentiation and the control of inflammation and innate immunity. In a bottom-up SB approach, current biological understanding is built into a kinetic model which is then applied to existing biological data to explain the function and identify unknown behavior. To date, this has not been applied to the VDR, but has to the related ERα and identified previously unknown mechanisms of control. One arena where applying top-down and bottom-up SB approaches may be informative is in the setting of prostate cancer health disparities. MDPI 2022-12-07 /pmc/articles/PMC9782494/ /pubmed/36558356 http://dx.doi.org/10.3390/nu14245197 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hussain, Shahid
Yates, Clayton
Campbell, Moray J.
Vitamin D and Systems Biology
title Vitamin D and Systems Biology
title_full Vitamin D and Systems Biology
title_fullStr Vitamin D and Systems Biology
title_full_unstemmed Vitamin D and Systems Biology
title_short Vitamin D and Systems Biology
title_sort vitamin d and systems biology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782494/
https://www.ncbi.nlm.nih.gov/pubmed/36558356
http://dx.doi.org/10.3390/nu14245197
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