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Strategies Tackling Viral Replication and Inflammatory Pathways as Early Pharmacological Treatment for SARS-CoV-2 Infection: Any Potential Role for Ketoprofen Lysine Salt?

COVID-19 is an infective disease resulting in widespread respiratory and non-respiratory symptoms prompted by SARS-CoV-2 infection. Interaction between SARS-CoV-2 and host cell receptors prompts activation of pro-inflammatory pathways which are involved in epithelial and endothelial damage mechanism...

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Autores principales: Mariniello, Domenica Francesca, Allocca, Valentino, D’Agnano, Vito, Villaro, Riccardo, Lanata, Luigi, Bagnasco, Michela, Aronne, Luigi, Bianco, Andrea, Perrotta, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782495/
https://www.ncbi.nlm.nih.gov/pubmed/36558048
http://dx.doi.org/10.3390/molecules27248919
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author Mariniello, Domenica Francesca
Allocca, Valentino
D’Agnano, Vito
Villaro, Riccardo
Lanata, Luigi
Bagnasco, Michela
Aronne, Luigi
Bianco, Andrea
Perrotta, Fabio
author_facet Mariniello, Domenica Francesca
Allocca, Valentino
D’Agnano, Vito
Villaro, Riccardo
Lanata, Luigi
Bagnasco, Michela
Aronne, Luigi
Bianco, Andrea
Perrotta, Fabio
author_sort Mariniello, Domenica Francesca
collection PubMed
description COVID-19 is an infective disease resulting in widespread respiratory and non-respiratory symptoms prompted by SARS-CoV-2 infection. Interaction between SARS-CoV-2 and host cell receptors prompts activation of pro-inflammatory pathways which are involved in epithelial and endothelial damage mechanisms even after viral clearance. Since inflammation has been recognized as a critical step in COVID-19, anti-inflammatory therapies, including both steroids and non-steroids as well as cytokine inhibitors, have been proposed. Early treatment of COVID-19 has the potential to affect the clinical course of the disease regardless of underlying comorbid conditions. Non-steroidal anti-inflammatory drugs (NSAIDs), which are widely used for symptomatic relief of upper airway infections, became the mainstay of early phase treatment of COVID-19. In this review, we discuss the current evidence for using NSAIDs in early phases of SARS-CoV-2 infection with focus on ketoprofen lysine salt based on its pharmacodynamic and pharmacokinetic features.
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spelling pubmed-97824952022-12-24 Strategies Tackling Viral Replication and Inflammatory Pathways as Early Pharmacological Treatment for SARS-CoV-2 Infection: Any Potential Role for Ketoprofen Lysine Salt? Mariniello, Domenica Francesca Allocca, Valentino D’Agnano, Vito Villaro, Riccardo Lanata, Luigi Bagnasco, Michela Aronne, Luigi Bianco, Andrea Perrotta, Fabio Molecules Review COVID-19 is an infective disease resulting in widespread respiratory and non-respiratory symptoms prompted by SARS-CoV-2 infection. Interaction between SARS-CoV-2 and host cell receptors prompts activation of pro-inflammatory pathways which are involved in epithelial and endothelial damage mechanisms even after viral clearance. Since inflammation has been recognized as a critical step in COVID-19, anti-inflammatory therapies, including both steroids and non-steroids as well as cytokine inhibitors, have been proposed. Early treatment of COVID-19 has the potential to affect the clinical course of the disease regardless of underlying comorbid conditions. Non-steroidal anti-inflammatory drugs (NSAIDs), which are widely used for symptomatic relief of upper airway infections, became the mainstay of early phase treatment of COVID-19. In this review, we discuss the current evidence for using NSAIDs in early phases of SARS-CoV-2 infection with focus on ketoprofen lysine salt based on its pharmacodynamic and pharmacokinetic features. MDPI 2022-12-15 /pmc/articles/PMC9782495/ /pubmed/36558048 http://dx.doi.org/10.3390/molecules27248919 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mariniello, Domenica Francesca
Allocca, Valentino
D’Agnano, Vito
Villaro, Riccardo
Lanata, Luigi
Bagnasco, Michela
Aronne, Luigi
Bianco, Andrea
Perrotta, Fabio
Strategies Tackling Viral Replication and Inflammatory Pathways as Early Pharmacological Treatment for SARS-CoV-2 Infection: Any Potential Role for Ketoprofen Lysine Salt?
title Strategies Tackling Viral Replication and Inflammatory Pathways as Early Pharmacological Treatment for SARS-CoV-2 Infection: Any Potential Role for Ketoprofen Lysine Salt?
title_full Strategies Tackling Viral Replication and Inflammatory Pathways as Early Pharmacological Treatment for SARS-CoV-2 Infection: Any Potential Role for Ketoprofen Lysine Salt?
title_fullStr Strategies Tackling Viral Replication and Inflammatory Pathways as Early Pharmacological Treatment for SARS-CoV-2 Infection: Any Potential Role for Ketoprofen Lysine Salt?
title_full_unstemmed Strategies Tackling Viral Replication and Inflammatory Pathways as Early Pharmacological Treatment for SARS-CoV-2 Infection: Any Potential Role for Ketoprofen Lysine Salt?
title_short Strategies Tackling Viral Replication and Inflammatory Pathways as Early Pharmacological Treatment for SARS-CoV-2 Infection: Any Potential Role for Ketoprofen Lysine Salt?
title_sort strategies tackling viral replication and inflammatory pathways as early pharmacological treatment for sars-cov-2 infection: any potential role for ketoprofen lysine salt?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782495/
https://www.ncbi.nlm.nih.gov/pubmed/36558048
http://dx.doi.org/10.3390/molecules27248919
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