Citrate Functionalized Zirconium-Based Metal Organic Framework for the Fluorescent Detection of Ciprofloxacin in Aqueous Media

Ciprofloxacin (CIP) is a commonly used antibiotic for the treatment of infectious diseases in humans and as a prophylactic agent in the livestock industry, leading to the environmental discharge of significant amounts of CIP. CIP is stable in aquatic systems leading to its pseudo-persistence. Constant exposure to these antibiotics results in the generation of antibiotic-resistant pathogens and potential toxicity/hypersensitivity in humans. Therefore, it is necessary to develop a convenient, rapid, and cost-effective method for the monitoring of ciprofloxacin in environmental samples. Rhodamine-based fluorescent receptors have the limitation of aqueous solubility. Therefore, in order to overcome this drawback, we designed a novel fluorescent receptor based on a zirconium-based metal organic framework (MOF-808). The precursor, MOF-808, was synthesized and functionalized by using sodium citrate to obtain a receptor called C-MOF-808. The C-MOF-808 was structurally characterized by XRD and spectroscopic analyses. Thus, this synthesized receptor can be used for the fluorescent detection of CIP in aqueous media with a detection limit of 9.4 µM. The detection phenomena of the receptor were studied by absorption as well as fluorescent spectra. The binding behavior of CIP with the receptor was studied by FT-IR and (1)H-NMR analyses, and a binding mechanism is proposed.