Cargando…
SARS-CoV-2 Specific Humoral Immune Responses after BNT162b2 Vaccination in Hospital Healthcare Workers
Background: COVID-19 pandemic has led to a loss of human life in millions and devastating socio-economic consequences worldwide. So far, vaccination is the most effective long-term strategy to control and prevent severe COVID-19 disease. The aim of the current study was to evaluate the humoral immun...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782529/ https://www.ncbi.nlm.nih.gov/pubmed/36560450 http://dx.doi.org/10.3390/vaccines10122038 |
_version_ | 1784857364779761664 |
---|---|
author | Golshani, Maryam Svobodová, Ludmila Maffei Štěpánek, Lubomír Zeman, Jan Nytrová, Petra Posová, Helena Petrásková, Petra Novotná, Olga Nováková, Michaela Černý, Viktor Beneš, Jiří Kolářová, Libuše Vokurka, Martin Hrdý, Jiří |
author_facet | Golshani, Maryam Svobodová, Ludmila Maffei Štěpánek, Lubomír Zeman, Jan Nytrová, Petra Posová, Helena Petrásková, Petra Novotná, Olga Nováková, Michaela Černý, Viktor Beneš, Jiří Kolářová, Libuše Vokurka, Martin Hrdý, Jiří |
author_sort | Golshani, Maryam |
collection | PubMed |
description | Background: COVID-19 pandemic has led to a loss of human life in millions and devastating socio-economic consequences worldwide. So far, vaccination is the most effective long-term strategy to control and prevent severe COVID-19 disease. The aim of the current study was to evaluate the humoral immune responses raised against the BNT162b2 vaccine in hospital healthcare workers. Methods: Total number of 173 healthcare workers enrolled in the study. Their blood samples were collected in three different time intervals after the second SARS-CoV-2 vaccination and evaluated by the ELISA method to detect anti-spike protein IgM and IgG antibodies. The baseline characteristics of all participants were collected using questionnaires and were evaluated for finding any significant data. Results: Our results demonstrated that the levels of antibodies were higher in the young group (21–30 years old) and also among male participants. Moreover, the highest levels of antibodies were detected from the group that received the third shot vaccination. Conclusions: Our results indicate that age, gender and third-dose vaccination can affect the levels of humoral immune responses against the BNT162b2 vaccine in healthcare workers. |
format | Online Article Text |
id | pubmed-9782529 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97825292022-12-24 SARS-CoV-2 Specific Humoral Immune Responses after BNT162b2 Vaccination in Hospital Healthcare Workers Golshani, Maryam Svobodová, Ludmila Maffei Štěpánek, Lubomír Zeman, Jan Nytrová, Petra Posová, Helena Petrásková, Petra Novotná, Olga Nováková, Michaela Černý, Viktor Beneš, Jiří Kolářová, Libuše Vokurka, Martin Hrdý, Jiří Vaccines (Basel) Article Background: COVID-19 pandemic has led to a loss of human life in millions and devastating socio-economic consequences worldwide. So far, vaccination is the most effective long-term strategy to control and prevent severe COVID-19 disease. The aim of the current study was to evaluate the humoral immune responses raised against the BNT162b2 vaccine in hospital healthcare workers. Methods: Total number of 173 healthcare workers enrolled in the study. Their blood samples were collected in three different time intervals after the second SARS-CoV-2 vaccination and evaluated by the ELISA method to detect anti-spike protein IgM and IgG antibodies. The baseline characteristics of all participants were collected using questionnaires and were evaluated for finding any significant data. Results: Our results demonstrated that the levels of antibodies were higher in the young group (21–30 years old) and also among male participants. Moreover, the highest levels of antibodies were detected from the group that received the third shot vaccination. Conclusions: Our results indicate that age, gender and third-dose vaccination can affect the levels of humoral immune responses against the BNT162b2 vaccine in healthcare workers. MDPI 2022-11-29 /pmc/articles/PMC9782529/ /pubmed/36560450 http://dx.doi.org/10.3390/vaccines10122038 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Golshani, Maryam Svobodová, Ludmila Maffei Štěpánek, Lubomír Zeman, Jan Nytrová, Petra Posová, Helena Petrásková, Petra Novotná, Olga Nováková, Michaela Černý, Viktor Beneš, Jiří Kolářová, Libuše Vokurka, Martin Hrdý, Jiří SARS-CoV-2 Specific Humoral Immune Responses after BNT162b2 Vaccination in Hospital Healthcare Workers |
title | SARS-CoV-2 Specific Humoral Immune Responses after BNT162b2 Vaccination in Hospital Healthcare Workers |
title_full | SARS-CoV-2 Specific Humoral Immune Responses after BNT162b2 Vaccination in Hospital Healthcare Workers |
title_fullStr | SARS-CoV-2 Specific Humoral Immune Responses after BNT162b2 Vaccination in Hospital Healthcare Workers |
title_full_unstemmed | SARS-CoV-2 Specific Humoral Immune Responses after BNT162b2 Vaccination in Hospital Healthcare Workers |
title_short | SARS-CoV-2 Specific Humoral Immune Responses after BNT162b2 Vaccination in Hospital Healthcare Workers |
title_sort | sars-cov-2 specific humoral immune responses after bnt162b2 vaccination in hospital healthcare workers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782529/ https://www.ncbi.nlm.nih.gov/pubmed/36560450 http://dx.doi.org/10.3390/vaccines10122038 |
work_keys_str_mv | AT golshanimaryam sarscov2specifichumoralimmuneresponsesafterbnt162b2vaccinationinhospitalhealthcareworkers AT svobodovaludmilamaffei sarscov2specifichumoralimmuneresponsesafterbnt162b2vaccinationinhospitalhealthcareworkers AT stepaneklubomir sarscov2specifichumoralimmuneresponsesafterbnt162b2vaccinationinhospitalhealthcareworkers AT zemanjan sarscov2specifichumoralimmuneresponsesafterbnt162b2vaccinationinhospitalhealthcareworkers AT nytrovapetra sarscov2specifichumoralimmuneresponsesafterbnt162b2vaccinationinhospitalhealthcareworkers AT posovahelena sarscov2specifichumoralimmuneresponsesafterbnt162b2vaccinationinhospitalhealthcareworkers AT petraskovapetra sarscov2specifichumoralimmuneresponsesafterbnt162b2vaccinationinhospitalhealthcareworkers AT novotnaolga sarscov2specifichumoralimmuneresponsesafterbnt162b2vaccinationinhospitalhealthcareworkers AT novakovamichaela sarscov2specifichumoralimmuneresponsesafterbnt162b2vaccinationinhospitalhealthcareworkers AT cernyviktor sarscov2specifichumoralimmuneresponsesafterbnt162b2vaccinationinhospitalhealthcareworkers AT benesjiri sarscov2specifichumoralimmuneresponsesafterbnt162b2vaccinationinhospitalhealthcareworkers AT kolarovalibuse sarscov2specifichumoralimmuneresponsesafterbnt162b2vaccinationinhospitalhealthcareworkers AT vokurkamartin sarscov2specifichumoralimmuneresponsesafterbnt162b2vaccinationinhospitalhealthcareworkers AT hrdyjiri sarscov2specifichumoralimmuneresponsesafterbnt162b2vaccinationinhospitalhealthcareworkers |