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Anti-MOG Positive Bilateral Optic Neuritis and Brainstem Encephalitis Secondary to COVID-19 Infection: A Case Report

(1) Introduction: There have been numerous reports on the neuroinvasive competence of SARS-CoV-2. Here, we present a case with anti-MOG positive bilateral optic neuritis and brainstem encephalitis secondary to COVID-19 infection. Additionally, we present a review of the current literature regarding...

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Autores principales: Tsouris, Zisis, Provatas, Antonios, Bakirtzis, Christos, Aloizou, Athina-Maria, Siokas, Vasileios, Tsimourtou, Vana, Grigoriadis, Nikolaos, Hadjigeorgiou, Georgios M., Dardiotis, Efthimios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782579/
https://www.ncbi.nlm.nih.gov/pubmed/36548183
http://dx.doi.org/10.3390/neurolint14040078
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author Tsouris, Zisis
Provatas, Antonios
Bakirtzis, Christos
Aloizou, Athina-Maria
Siokas, Vasileios
Tsimourtou, Vana
Grigoriadis, Nikolaos
Hadjigeorgiou, Georgios M.
Dardiotis, Efthimios
author_facet Tsouris, Zisis
Provatas, Antonios
Bakirtzis, Christos
Aloizou, Athina-Maria
Siokas, Vasileios
Tsimourtou, Vana
Grigoriadis, Nikolaos
Hadjigeorgiou, Georgios M.
Dardiotis, Efthimios
author_sort Tsouris, Zisis
collection PubMed
description (1) Introduction: There have been numerous reports on the neuroinvasive competence of SARS-CoV-2. Here, we present a case with anti-MOG positive bilateral optic neuritis and brainstem encephalitis secondary to COVID-19 infection. Additionally, we present a review of the current literature regarding the manifestation of anti-MOG positive optic neuritis as well as anti-MOG positive encephalitis after COVID-19 infection. (2) Case Report: A 59-year-old female patient, with a recent history of COVID-19 infection, presented a progressive reduction of visual acuity and bilateral retrobulbar pain for the last 20 days. An ophthalmological examination revealed a decreased visual acuity (counting fingers) and a bilateral papilledema. An MRI scan of the brain revealed a mild thickening of the bilateral optic nerves and high-intensity lesions in the medial and right lateral pons. A high titer of IgG and IgM antibodies against SARS-CoV-2 in serum and antibodies against myelin oligodendrocyte glycoprotein (anti-MOG) in serum and CSF were revealed. The diagnosis of anti-MOG brainstem encephalitis and optic neuritis was set. (3) Conclusions: The history of COVID-19 infection should raise awareness about these autoimmune and infection-triggered diseases, such as anti-MOG antibody disease.
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spelling pubmed-97825792022-12-24 Anti-MOG Positive Bilateral Optic Neuritis and Brainstem Encephalitis Secondary to COVID-19 Infection: A Case Report Tsouris, Zisis Provatas, Antonios Bakirtzis, Christos Aloizou, Athina-Maria Siokas, Vasileios Tsimourtou, Vana Grigoriadis, Nikolaos Hadjigeorgiou, Georgios M. Dardiotis, Efthimios Neurol Int Case Report (1) Introduction: There have been numerous reports on the neuroinvasive competence of SARS-CoV-2. Here, we present a case with anti-MOG positive bilateral optic neuritis and brainstem encephalitis secondary to COVID-19 infection. Additionally, we present a review of the current literature regarding the manifestation of anti-MOG positive optic neuritis as well as anti-MOG positive encephalitis after COVID-19 infection. (2) Case Report: A 59-year-old female patient, with a recent history of COVID-19 infection, presented a progressive reduction of visual acuity and bilateral retrobulbar pain for the last 20 days. An ophthalmological examination revealed a decreased visual acuity (counting fingers) and a bilateral papilledema. An MRI scan of the brain revealed a mild thickening of the bilateral optic nerves and high-intensity lesions in the medial and right lateral pons. A high titer of IgG and IgM antibodies against SARS-CoV-2 in serum and antibodies against myelin oligodendrocyte glycoprotein (anti-MOG) in serum and CSF were revealed. The diagnosis of anti-MOG brainstem encephalitis and optic neuritis was set. (3) Conclusions: The history of COVID-19 infection should raise awareness about these autoimmune and infection-triggered diseases, such as anti-MOG antibody disease. MDPI 2022-11-30 /pmc/articles/PMC9782579/ /pubmed/36548183 http://dx.doi.org/10.3390/neurolint14040078 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Tsouris, Zisis
Provatas, Antonios
Bakirtzis, Christos
Aloizou, Athina-Maria
Siokas, Vasileios
Tsimourtou, Vana
Grigoriadis, Nikolaos
Hadjigeorgiou, Georgios M.
Dardiotis, Efthimios
Anti-MOG Positive Bilateral Optic Neuritis and Brainstem Encephalitis Secondary to COVID-19 Infection: A Case Report
title Anti-MOG Positive Bilateral Optic Neuritis and Brainstem Encephalitis Secondary to COVID-19 Infection: A Case Report
title_full Anti-MOG Positive Bilateral Optic Neuritis and Brainstem Encephalitis Secondary to COVID-19 Infection: A Case Report
title_fullStr Anti-MOG Positive Bilateral Optic Neuritis and Brainstem Encephalitis Secondary to COVID-19 Infection: A Case Report
title_full_unstemmed Anti-MOG Positive Bilateral Optic Neuritis and Brainstem Encephalitis Secondary to COVID-19 Infection: A Case Report
title_short Anti-MOG Positive Bilateral Optic Neuritis and Brainstem Encephalitis Secondary to COVID-19 Infection: A Case Report
title_sort anti-mog positive bilateral optic neuritis and brainstem encephalitis secondary to covid-19 infection: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782579/
https://www.ncbi.nlm.nih.gov/pubmed/36548183
http://dx.doi.org/10.3390/neurolint14040078
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