Pharmacological Effects and Clinical Prospects of Cepharanthine

Cepharanthine is an active ingredient separated and extracted from Stephania cepharantha Hayata, a Menispermaceae plant. As a bisbenzylisoquinoline alkaloid, cepharanthine has various pharmacological properties, including antioxidant, anti-inflammatory, immunomodulatory, antitumoral, and antiviral e...

Descripción completa

Detalles Bibliográficos
Autores principales: Liang, Di, Li, Qi, Du, Lina, Dou, Guifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782661/
https://www.ncbi.nlm.nih.gov/pubmed/36558061
http://dx.doi.org/10.3390/molecules27248933
_version_ 1784857397348532224
author Liang, Di
Li, Qi
Du, Lina
Dou, Guifang
author_facet Liang, Di
Li, Qi
Du, Lina
Dou, Guifang
author_sort Liang, Di
collection PubMed
description Cepharanthine is an active ingredient separated and extracted from Stephania cepharantha Hayata, a Menispermaceae plant. As a bisbenzylisoquinoline alkaloid, cepharanthine has various pharmacological properties, including antioxidant, anti-inflammatory, immunomodulatory, antitumoral, and antiviral effects. Following the emergence of coronavirus disease 2019 (COVID-19), cepharanthine has been found to have excellent anti-COVID-19 activity. In this review, the important physicochemical properties and pharmacological effects of cepharanthine, particularly the antiviral effect, are systematically described. Additionally, the molecular mechanisms and novel dosage formulations for the efficient, safe, and convenient delivery of cepharanthine are summarized.
format Online
Article
Text
id pubmed-9782661
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97826612022-12-24 Pharmacological Effects and Clinical Prospects of Cepharanthine Liang, Di Li, Qi Du, Lina Dou, Guifang Molecules Review Cepharanthine is an active ingredient separated and extracted from Stephania cepharantha Hayata, a Menispermaceae plant. As a bisbenzylisoquinoline alkaloid, cepharanthine has various pharmacological properties, including antioxidant, anti-inflammatory, immunomodulatory, antitumoral, and antiviral effects. Following the emergence of coronavirus disease 2019 (COVID-19), cepharanthine has been found to have excellent anti-COVID-19 activity. In this review, the important physicochemical properties and pharmacological effects of cepharanthine, particularly the antiviral effect, are systematically described. Additionally, the molecular mechanisms and novel dosage formulations for the efficient, safe, and convenient delivery of cepharanthine are summarized. MDPI 2022-12-15 /pmc/articles/PMC9782661/ /pubmed/36558061 http://dx.doi.org/10.3390/molecules27248933 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liang, Di
Li, Qi
Du, Lina
Dou, Guifang
Pharmacological Effects and Clinical Prospects of Cepharanthine
title Pharmacological Effects and Clinical Prospects of Cepharanthine
title_full Pharmacological Effects and Clinical Prospects of Cepharanthine
title_fullStr Pharmacological Effects and Clinical Prospects of Cepharanthine
title_full_unstemmed Pharmacological Effects and Clinical Prospects of Cepharanthine
title_short Pharmacological Effects and Clinical Prospects of Cepharanthine
title_sort pharmacological effects and clinical prospects of cepharanthine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782661/
https://www.ncbi.nlm.nih.gov/pubmed/36558061
http://dx.doi.org/10.3390/molecules27248933
work_keys_str_mv AT liangdi pharmacologicaleffectsandclinicalprospectsofcepharanthine
AT liqi pharmacologicaleffectsandclinicalprospectsofcepharanthine
AT dulina pharmacologicaleffectsandclinicalprospectsofcepharanthine
AT douguifang pharmacologicaleffectsandclinicalprospectsofcepharanthine

Ejemplares similares