Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities

Women are significantly more likely to develop tuberculosis (TB) disease within the first 90 days after pregnancy than any other time in their lives. Whether pregnancy increases risk of progression from TB infection (TBI) to TB disease is unknown and is an active area of investigation. In this revie...

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Detalles Bibliográficos
Autores principales: Mathad, Jyoti S., Yadav, Sharan, Vaidyanathan, Arthi, Gupta, Amita, LaCourse, Sylvia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782762/
https://www.ncbi.nlm.nih.gov/pubmed/36558815
http://dx.doi.org/10.3390/pathogens11121481
Descripción
Sumario:Women are significantly more likely to develop tuberculosis (TB) disease within the first 90 days after pregnancy than any other time in their lives. Whether pregnancy increases risk of progression from TB infection (TBI) to TB disease is unknown and is an active area of investigation. In this review, we discuss the epidemiology of TB and TBI in pregnancy, TBI diagnostics, and prevalence in pregnancy. We also review TBI treatment and highlight research priorities, such as short-course TB prevention regimens, drug-resistant TB prevention, and additional considerations for safety, tolerability, and pharmacokinetics that are unique to pregnant and postpartum people.

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