Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities

Women are significantly more likely to develop tuberculosis (TB) disease within the first 90 days after pregnancy than any other time in their lives. Whether pregnancy increases risk of progression from TB infection (TBI) to TB disease is unknown and is an active area of investigation. In this revie...

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Autores principales: Mathad, Jyoti S., Yadav, Sharan, Vaidyanathan, Arthi, Gupta, Amita, LaCourse, Sylvia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782762/
https://www.ncbi.nlm.nih.gov/pubmed/36558815
http://dx.doi.org/10.3390/pathogens11121481
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author Mathad, Jyoti S.
Yadav, Sharan
Vaidyanathan, Arthi
Gupta, Amita
LaCourse, Sylvia M.
author_facet Mathad, Jyoti S.
Yadav, Sharan
Vaidyanathan, Arthi
Gupta, Amita
LaCourse, Sylvia M.
author_sort Mathad, Jyoti S.
collection PubMed
description Women are significantly more likely to develop tuberculosis (TB) disease within the first 90 days after pregnancy than any other time in their lives. Whether pregnancy increases risk of progression from TB infection (TBI) to TB disease is unknown and is an active area of investigation. In this review, we discuss the epidemiology of TB and TBI in pregnancy, TBI diagnostics, and prevalence in pregnancy. We also review TBI treatment and highlight research priorities, such as short-course TB prevention regimens, drug-resistant TB prevention, and additional considerations for safety, tolerability, and pharmacokinetics that are unique to pregnant and postpartum people.
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spelling pubmed-97827622022-12-24 Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities Mathad, Jyoti S. Yadav, Sharan Vaidyanathan, Arthi Gupta, Amita LaCourse, Sylvia M. Pathogens Review Women are significantly more likely to develop tuberculosis (TB) disease within the first 90 days after pregnancy than any other time in their lives. Whether pregnancy increases risk of progression from TB infection (TBI) to TB disease is unknown and is an active area of investigation. In this review, we discuss the epidemiology of TB and TBI in pregnancy, TBI diagnostics, and prevalence in pregnancy. We also review TBI treatment and highlight research priorities, such as short-course TB prevention regimens, drug-resistant TB prevention, and additional considerations for safety, tolerability, and pharmacokinetics that are unique to pregnant and postpartum people. MDPI 2022-12-06 /pmc/articles/PMC9782762/ /pubmed/36558815 http://dx.doi.org/10.3390/pathogens11121481 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mathad, Jyoti S.
Yadav, Sharan
Vaidyanathan, Arthi
Gupta, Amita
LaCourse, Sylvia M.
Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities
title Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities
title_full Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities
title_fullStr Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities
title_full_unstemmed Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities
title_short Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities
title_sort tuberculosis infection in pregnant people: current practices and research priorities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782762/
https://www.ncbi.nlm.nih.gov/pubmed/36558815
http://dx.doi.org/10.3390/pathogens11121481
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