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Utilization of Physiologically Based Pharmacokinetic Modeling in Pharmacokinetic Study of Natural Medicine: An Overview

Natural medicine has been widely used for clinical treatment and health care in many countries and regions. Additionally, extracting active ingredients from traditional Chinese medicine and other natural plants, defining their chemical structure and pharmacological effects, and screening potential d...

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Detalles Bibliográficos
Autores principales: Jia, Qiuyu, He, Qingfeng, Yao, Li, Li, Min, Lin, Jiaying, Tang, Zhijia, Zhu, Xiao, Xiang, Xiaoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782767/
https://www.ncbi.nlm.nih.gov/pubmed/36557804
http://dx.doi.org/10.3390/molecules27248670
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author Jia, Qiuyu
He, Qingfeng
Yao, Li
Li, Min
Lin, Jiaying
Tang, Zhijia
Zhu, Xiao
Xiang, Xiaoqiang
author_facet Jia, Qiuyu
He, Qingfeng
Yao, Li
Li, Min
Lin, Jiaying
Tang, Zhijia
Zhu, Xiao
Xiang, Xiaoqiang
author_sort Jia, Qiuyu
collection PubMed
description Natural medicine has been widely used for clinical treatment and health care in many countries and regions. Additionally, extracting active ingredients from traditional Chinese medicine and other natural plants, defining their chemical structure and pharmacological effects, and screening potential druggable candidates are also uprising directions in new drug research and development. Physiologically based pharmacokinetic (PBPK) modeling is a mathematical modeling technique that simulates the absorption, distribution, metabolism, and elimination of drugs in various tissues and organs in vivo based on physiological and anatomical characteristics and physicochemical properties. PBPK modeling in drug research and development has gradually been recognized by regulatory authorities in recent years, including the U.S. Food and Drug Administration. This review summarizes the general situation and shortcomings of the current research on the pharmacokinetics of natural medicine and introduces the concept and the advantages of the PBPK model in the study of pharmacokinetics of natural medicine. Finally, the pharmacokinetic studies of natural medicine using the PBPK models are summed up, followed by discussions on the applications of PBPK modeling to the enzyme-mediated pharmacokinetic changes, special populations, new drug research and development, and new indication adding for natural medicine. This paper aims to provide a novel strategy for the preclinical research and clinical use of natural medicine.
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spelling pubmed-97827672022-12-24 Utilization of Physiologically Based Pharmacokinetic Modeling in Pharmacokinetic Study of Natural Medicine: An Overview Jia, Qiuyu He, Qingfeng Yao, Li Li, Min Lin, Jiaying Tang, Zhijia Zhu, Xiao Xiang, Xiaoqiang Molecules Review Natural medicine has been widely used for clinical treatment and health care in many countries and regions. Additionally, extracting active ingredients from traditional Chinese medicine and other natural plants, defining their chemical structure and pharmacological effects, and screening potential druggable candidates are also uprising directions in new drug research and development. Physiologically based pharmacokinetic (PBPK) modeling is a mathematical modeling technique that simulates the absorption, distribution, metabolism, and elimination of drugs in various tissues and organs in vivo based on physiological and anatomical characteristics and physicochemical properties. PBPK modeling in drug research and development has gradually been recognized by regulatory authorities in recent years, including the U.S. Food and Drug Administration. This review summarizes the general situation and shortcomings of the current research on the pharmacokinetics of natural medicine and introduces the concept and the advantages of the PBPK model in the study of pharmacokinetics of natural medicine. Finally, the pharmacokinetic studies of natural medicine using the PBPK models are summed up, followed by discussions on the applications of PBPK modeling to the enzyme-mediated pharmacokinetic changes, special populations, new drug research and development, and new indication adding for natural medicine. This paper aims to provide a novel strategy for the preclinical research and clinical use of natural medicine. MDPI 2022-12-08 /pmc/articles/PMC9782767/ /pubmed/36557804 http://dx.doi.org/10.3390/molecules27248670 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jia, Qiuyu
He, Qingfeng
Yao, Li
Li, Min
Lin, Jiaying
Tang, Zhijia
Zhu, Xiao
Xiang, Xiaoqiang
Utilization of Physiologically Based Pharmacokinetic Modeling in Pharmacokinetic Study of Natural Medicine: An Overview
title Utilization of Physiologically Based Pharmacokinetic Modeling in Pharmacokinetic Study of Natural Medicine: An Overview
title_full Utilization of Physiologically Based Pharmacokinetic Modeling in Pharmacokinetic Study of Natural Medicine: An Overview
title_fullStr Utilization of Physiologically Based Pharmacokinetic Modeling in Pharmacokinetic Study of Natural Medicine: An Overview
title_full_unstemmed Utilization of Physiologically Based Pharmacokinetic Modeling in Pharmacokinetic Study of Natural Medicine: An Overview
title_short Utilization of Physiologically Based Pharmacokinetic Modeling in Pharmacokinetic Study of Natural Medicine: An Overview
title_sort utilization of physiologically based pharmacokinetic modeling in pharmacokinetic study of natural medicine: an overview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782767/
https://www.ncbi.nlm.nih.gov/pubmed/36557804
http://dx.doi.org/10.3390/molecules27248670
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