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Electrical Stimuli-Responsive Decomposition of Layer-by-Layer Films Composed of Polycations and TEMPO-Modified Poly(acrylic acid)

We previously reported that layer-by-layer (LbL) film prepared by a combination of 2,2,6,6-tetramethylpiperidinyl N-oxyl (TEMPO)-modified polyacrylic acid (PAA) and polyethyleneimine (PEI) were decomposed by application of an electric potential. However, there have been no reports yet for other poly...

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Autores principales: Yoshida, Kentaro, Kamijo, Toshio, Ono, Tetsuya, Dairaku, Takenori, Takahashi, Shigehiro, Kashiwagi, Yoshitomo, Sato, Katsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782790/
https://www.ncbi.nlm.nih.gov/pubmed/36559714
http://dx.doi.org/10.3390/polym14245349
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author Yoshida, Kentaro
Kamijo, Toshio
Ono, Tetsuya
Dairaku, Takenori
Takahashi, Shigehiro
Kashiwagi, Yoshitomo
Sato, Katsuhiko
author_facet Yoshida, Kentaro
Kamijo, Toshio
Ono, Tetsuya
Dairaku, Takenori
Takahashi, Shigehiro
Kashiwagi, Yoshitomo
Sato, Katsuhiko
author_sort Yoshida, Kentaro
collection PubMed
description We previously reported that layer-by-layer (LbL) film prepared by a combination of 2,2,6,6-tetramethylpiperidinyl N-oxyl (TEMPO)-modified polyacrylic acid (PAA) and polyethyleneimine (PEI) were decomposed by application of an electric potential. However, there have been no reports yet for other polycationic species. In this study, LbL films were prepared by combining various polycationics (PEI, poly(allylamine hydrochloride) (PAH), poly(diallydimethylammonium chloride) (PDDA), and polyamidoamine (PAMAM) dendrimer) and TEMPO-PAA, and the decomposition of the thin films was evaluated using cyclic voltammetry (CV) and constant potential using an electrochemical quartz crystal microbalance (eQCM). When a potential was applied to an electrode coated on an LbL thin film of polycations and TEMPO-PAA, an oxidation potential peak (Ep(a)) was obtained around +0.6 V vs. Ag/AgCl in CV measurements. EQCM measurements showed the decomposition of the LbL films at voltages near the Ep(a) of the TEMPO residues. Decomposition rate was 82% for the (PEI/TEMPO-PAA)(5) film, 52% for the (PAH/TEMPO-PAA)(5) film, and 49% for the (PDDA/TEMPO-PAA)(5) film. It is considered that the oxoammonium ion has a positive charge, and the LbL films were decomposed due to electrostatic repulsion with the polycations (PEI, PAH, and PDDA). These LbL films may lead to applications in drug release by electrical stimulation. On the other hand, the CV of the (PAMAM/TEMPO-PAA)(5) film did not decompose. It is possible that the decomposition of the thin film is not promoted, probably because the amount of TEMPO-PAA absorbed is small.
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spelling pubmed-97827902022-12-24 Electrical Stimuli-Responsive Decomposition of Layer-by-Layer Films Composed of Polycations and TEMPO-Modified Poly(acrylic acid) Yoshida, Kentaro Kamijo, Toshio Ono, Tetsuya Dairaku, Takenori Takahashi, Shigehiro Kashiwagi, Yoshitomo Sato, Katsuhiko Polymers (Basel) Article We previously reported that layer-by-layer (LbL) film prepared by a combination of 2,2,6,6-tetramethylpiperidinyl N-oxyl (TEMPO)-modified polyacrylic acid (PAA) and polyethyleneimine (PEI) were decomposed by application of an electric potential. However, there have been no reports yet for other polycationic species. In this study, LbL films were prepared by combining various polycationics (PEI, poly(allylamine hydrochloride) (PAH), poly(diallydimethylammonium chloride) (PDDA), and polyamidoamine (PAMAM) dendrimer) and TEMPO-PAA, and the decomposition of the thin films was evaluated using cyclic voltammetry (CV) and constant potential using an electrochemical quartz crystal microbalance (eQCM). When a potential was applied to an electrode coated on an LbL thin film of polycations and TEMPO-PAA, an oxidation potential peak (Ep(a)) was obtained around +0.6 V vs. Ag/AgCl in CV measurements. EQCM measurements showed the decomposition of the LbL films at voltages near the Ep(a) of the TEMPO residues. Decomposition rate was 82% for the (PEI/TEMPO-PAA)(5) film, 52% for the (PAH/TEMPO-PAA)(5) film, and 49% for the (PDDA/TEMPO-PAA)(5) film. It is considered that the oxoammonium ion has a positive charge, and the LbL films were decomposed due to electrostatic repulsion with the polycations (PEI, PAH, and PDDA). These LbL films may lead to applications in drug release by electrical stimulation. On the other hand, the CV of the (PAMAM/TEMPO-PAA)(5) film did not decompose. It is possible that the decomposition of the thin film is not promoted, probably because the amount of TEMPO-PAA absorbed is small. MDPI 2022-12-07 /pmc/articles/PMC9782790/ /pubmed/36559714 http://dx.doi.org/10.3390/polym14245349 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoshida, Kentaro
Kamijo, Toshio
Ono, Tetsuya
Dairaku, Takenori
Takahashi, Shigehiro
Kashiwagi, Yoshitomo
Sato, Katsuhiko
Electrical Stimuli-Responsive Decomposition of Layer-by-Layer Films Composed of Polycations and TEMPO-Modified Poly(acrylic acid)
title Electrical Stimuli-Responsive Decomposition of Layer-by-Layer Films Composed of Polycations and TEMPO-Modified Poly(acrylic acid)
title_full Electrical Stimuli-Responsive Decomposition of Layer-by-Layer Films Composed of Polycations and TEMPO-Modified Poly(acrylic acid)
title_fullStr Electrical Stimuli-Responsive Decomposition of Layer-by-Layer Films Composed of Polycations and TEMPO-Modified Poly(acrylic acid)
title_full_unstemmed Electrical Stimuli-Responsive Decomposition of Layer-by-Layer Films Composed of Polycations and TEMPO-Modified Poly(acrylic acid)
title_short Electrical Stimuli-Responsive Decomposition of Layer-by-Layer Films Composed of Polycations and TEMPO-Modified Poly(acrylic acid)
title_sort electrical stimuli-responsive decomposition of layer-by-layer films composed of polycations and tempo-modified poly(acrylic acid)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782790/
https://www.ncbi.nlm.nih.gov/pubmed/36559714
http://dx.doi.org/10.3390/polym14245349
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