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The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment

Cancer is a main culprit and the second-leading cause of death worldwide. The current mode of treatment strategies including surgery with chemotherapy and radiation therapy may be effective, but cancer is still considered a major cause of death. Plant-derived products or their purified bioactive com...

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Autores principales: Rahmani, Arshad Husain, Almatroudi, Ahmad, Allemailem, Khaled S., Khan, Amjad Ali, Almatroodi, Saleh A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782831/
https://www.ncbi.nlm.nih.gov/pubmed/36558146
http://dx.doi.org/10.3390/molecules27249009
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author Rahmani, Arshad Husain
Almatroudi, Ahmad
Allemailem, Khaled S.
Khan, Amjad Ali
Almatroodi, Saleh A.
author_facet Rahmani, Arshad Husain
Almatroudi, Ahmad
Allemailem, Khaled S.
Khan, Amjad Ali
Almatroodi, Saleh A.
author_sort Rahmani, Arshad Husain
collection PubMed
description Cancer is a main culprit and the second-leading cause of death worldwide. The current mode of treatment strategies including surgery with chemotherapy and radiation therapy may be effective, but cancer is still considered a major cause of death. Plant-derived products or their purified bioactive compounds have confirmed health-promoting effects as well as cancer-preventive effects. Among these products, flavonoids belong to polyphenols, chiefly found in fruits, vegetables and in various seeds/flowers. It has been considered to be an effective antioxidant, anti-inflammatory and to play a vital role in diseases management. Besides these activities, flavonoids have been revealed to possess anticancer potential through the modulation of various cell signaling molecules. In this regard, fisetin, a naturally occurring flavonoid, has a confirmed role in disease management through antioxidant, neuro-protective, anti-diabetic, hepato-protective and reno-protective potential. As well, its cancer-preventive effects have been confirmed via modulating various cell signaling pathways including inflammation, apoptosis, angiogenesis, growth factor, transcription factor and other cell signaling pathways. This review presents an overview of the anti-cancer potential of fisetin in different types of cancer through the modulation of cell signaling pathways based on in vivo and in vitro studies. A synergistic effect with anticancer drugs and strategies to improve the bioavailability are described. More clinical trials need to be performed to explore the anti-cancer potential and mechanism-of-action of fisetin and its optimum therapeutic dose.
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spelling pubmed-97828312022-12-24 The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment Rahmani, Arshad Husain Almatroudi, Ahmad Allemailem, Khaled S. Khan, Amjad Ali Almatroodi, Saleh A. Molecules Review Cancer is a main culprit and the second-leading cause of death worldwide. The current mode of treatment strategies including surgery with chemotherapy and radiation therapy may be effective, but cancer is still considered a major cause of death. Plant-derived products or their purified bioactive compounds have confirmed health-promoting effects as well as cancer-preventive effects. Among these products, flavonoids belong to polyphenols, chiefly found in fruits, vegetables and in various seeds/flowers. It has been considered to be an effective antioxidant, anti-inflammatory and to play a vital role in diseases management. Besides these activities, flavonoids have been revealed to possess anticancer potential through the modulation of various cell signaling molecules. In this regard, fisetin, a naturally occurring flavonoid, has a confirmed role in disease management through antioxidant, neuro-protective, anti-diabetic, hepato-protective and reno-protective potential. As well, its cancer-preventive effects have been confirmed via modulating various cell signaling pathways including inflammation, apoptosis, angiogenesis, growth factor, transcription factor and other cell signaling pathways. This review presents an overview of the anti-cancer potential of fisetin in different types of cancer through the modulation of cell signaling pathways based on in vivo and in vitro studies. A synergistic effect with anticancer drugs and strategies to improve the bioavailability are described. More clinical trials need to be performed to explore the anti-cancer potential and mechanism-of-action of fisetin and its optimum therapeutic dose. MDPI 2022-12-17 /pmc/articles/PMC9782831/ /pubmed/36558146 http://dx.doi.org/10.3390/molecules27249009 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rahmani, Arshad Husain
Almatroudi, Ahmad
Allemailem, Khaled S.
Khan, Amjad Ali
Almatroodi, Saleh A.
The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
title The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
title_full The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
title_fullStr The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
title_full_unstemmed The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
title_short The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
title_sort potential role of fisetin, a flavonoid in cancer prevention and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782831/
https://www.ncbi.nlm.nih.gov/pubmed/36558146
http://dx.doi.org/10.3390/molecules27249009
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