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Potential Drug Targets for Ceramide Metabolism in Cardiovascular Disease

Cardiovascular disease poses a significant threat to the quality of human life. Metabolic abnormalities caused by excessive caloric intake have been shown to lead to the development of cardiovascular diseases. Ceramides are structural molecules found in biological membranes; they are crucial for cel...

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Detalles Bibliográficos
Autores principales: Guo, Jiaying, Feng, Jiling, Qu, Huiyan, Xu, Hongxi, Zhou, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782850/
https://www.ncbi.nlm.nih.gov/pubmed/36547431
http://dx.doi.org/10.3390/jcdd9120434
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author Guo, Jiaying
Feng, Jiling
Qu, Huiyan
Xu, Hongxi
Zhou, Hua
author_facet Guo, Jiaying
Feng, Jiling
Qu, Huiyan
Xu, Hongxi
Zhou, Hua
author_sort Guo, Jiaying
collection PubMed
description Cardiovascular disease poses a significant threat to the quality of human life. Metabolic abnormalities caused by excessive caloric intake have been shown to lead to the development of cardiovascular diseases. Ceramides are structural molecules found in biological membranes; they are crucial for cell survival and lipid metabolism, as they maintain barrier function and membrane fluidity. Increasing evidence has demonstrated that ceramide has a strong correlation with cardiovascular disease progression. Nevertheless, it remains a challenge to develop sphingolipids as therapeutic targets to improve the prognosis of cardiovascular diseases. In this review, we summarize the three synthesis pathways of ceramide and other intermediates that are important in ceramide metabolism. Furthermore, mechanistic studies and therapeutic strategies, including clinical drugs and bioactive molecules based on these intermediates, are discussed.
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spelling pubmed-97828502022-12-24 Potential Drug Targets for Ceramide Metabolism in Cardiovascular Disease Guo, Jiaying Feng, Jiling Qu, Huiyan Xu, Hongxi Zhou, Hua J Cardiovasc Dev Dis Review Cardiovascular disease poses a significant threat to the quality of human life. Metabolic abnormalities caused by excessive caloric intake have been shown to lead to the development of cardiovascular diseases. Ceramides are structural molecules found in biological membranes; they are crucial for cell survival and lipid metabolism, as they maintain barrier function and membrane fluidity. Increasing evidence has demonstrated that ceramide has a strong correlation with cardiovascular disease progression. Nevertheless, it remains a challenge to develop sphingolipids as therapeutic targets to improve the prognosis of cardiovascular diseases. In this review, we summarize the three synthesis pathways of ceramide and other intermediates that are important in ceramide metabolism. Furthermore, mechanistic studies and therapeutic strategies, including clinical drugs and bioactive molecules based on these intermediates, are discussed. MDPI 2022-12-02 /pmc/articles/PMC9782850/ /pubmed/36547431 http://dx.doi.org/10.3390/jcdd9120434 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Guo, Jiaying
Feng, Jiling
Qu, Huiyan
Xu, Hongxi
Zhou, Hua
Potential Drug Targets for Ceramide Metabolism in Cardiovascular Disease
title Potential Drug Targets for Ceramide Metabolism in Cardiovascular Disease
title_full Potential Drug Targets for Ceramide Metabolism in Cardiovascular Disease
title_fullStr Potential Drug Targets for Ceramide Metabolism in Cardiovascular Disease
title_full_unstemmed Potential Drug Targets for Ceramide Metabolism in Cardiovascular Disease
title_short Potential Drug Targets for Ceramide Metabolism in Cardiovascular Disease
title_sort potential drug targets for ceramide metabolism in cardiovascular disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782850/
https://www.ncbi.nlm.nih.gov/pubmed/36547431
http://dx.doi.org/10.3390/jcdd9120434
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