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Effects of Thymoquinone Alone or in Combination with Losartan on the Cardiotoxicity Caused by Oxidative Stress and Inflammation in Hypercholesterolemia

Dietary cholesterol accelerates oxidative and pro-inflammatory processes, causing hypercholesterolemia and cardiovascular diseases. Thus, the purpose of the current study is to compare the protective effects of thymoquinone (TQ) alone or in combination with losartan (LT) against the heart damage cau...

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Autores principales: Al-Oanzi, Ziad H., Alenazy, Fawaz O., Alhassan, Hassan H., El-Aassar, Mohamed R., Alzarea, Abdulaziz I., Alzarea, Sami I., Abbas, Anass M., Alanazi, Muteb H., Al-Enazi, Maher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782872/
https://www.ncbi.nlm.nih.gov/pubmed/36547425
http://dx.doi.org/10.3390/jcdd9120428
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author Al-Oanzi, Ziad H.
Alenazy, Fawaz O.
Alhassan, Hassan H.
El-Aassar, Mohamed R.
Alzarea, Abdulaziz I.
Alzarea, Sami I.
Abbas, Anass M.
Alanazi, Muteb H.
Al-Enazi, Maher M.
author_facet Al-Oanzi, Ziad H.
Alenazy, Fawaz O.
Alhassan, Hassan H.
El-Aassar, Mohamed R.
Alzarea, Abdulaziz I.
Alzarea, Sami I.
Abbas, Anass M.
Alanazi, Muteb H.
Al-Enazi, Maher M.
author_sort Al-Oanzi, Ziad H.
collection PubMed
description Dietary cholesterol accelerates oxidative and pro-inflammatory processes, causing hypercholesterolemia and cardiovascular diseases. Thus, the purpose of the current study is to compare the protective effects of thymoquinone (TQ) alone or in combination with losartan (LT) against the heart damage caused by a high-cholesterol diet (HCD). HCD-fed rat groups revealed an elevated activity of indicators of cardiac enzymes in the serum. Serum and cardiac lipids were also found to be significantly higher in HCD-fed rat groups. Cardiac pro-inflammatory and oxidative markers were also increased in HCD-fed rat groups, whereas antioxidant indicators were decreased. However, all of these biochemical, inflammatory, antioxidant, and oxidative change indicators returned to levels similar to those of normal rats after treatment with TQ alone or in combination with LT administered to HCD-fed rat groups. Hypercholesterolemia considerably induced the lipid peroxidation product, thiobarbituric acid reaction substances (TBARs), and oxidative radicals in cardiac cells, which were attenuated by QT and LT treatments, particularly when combined. Finally, QT, LT, and their combination were able to reduce the histological changes changes brought on by cholesterol excess in cardiac tissues. In conclusion, administration of TQ in a combination with LT which has a better protective effect, significantly reduced the hypercholesterolemic-induced oxidative and inflammatory changes that occurred in cardiac tissue.
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spelling pubmed-97828722022-12-24 Effects of Thymoquinone Alone or in Combination with Losartan on the Cardiotoxicity Caused by Oxidative Stress and Inflammation in Hypercholesterolemia Al-Oanzi, Ziad H. Alenazy, Fawaz O. Alhassan, Hassan H. El-Aassar, Mohamed R. Alzarea, Abdulaziz I. Alzarea, Sami I. Abbas, Anass M. Alanazi, Muteb H. Al-Enazi, Maher M. J Cardiovasc Dev Dis Article Dietary cholesterol accelerates oxidative and pro-inflammatory processes, causing hypercholesterolemia and cardiovascular diseases. Thus, the purpose of the current study is to compare the protective effects of thymoquinone (TQ) alone or in combination with losartan (LT) against the heart damage caused by a high-cholesterol diet (HCD). HCD-fed rat groups revealed an elevated activity of indicators of cardiac enzymes in the serum. Serum and cardiac lipids were also found to be significantly higher in HCD-fed rat groups. Cardiac pro-inflammatory and oxidative markers were also increased in HCD-fed rat groups, whereas antioxidant indicators were decreased. However, all of these biochemical, inflammatory, antioxidant, and oxidative change indicators returned to levels similar to those of normal rats after treatment with TQ alone or in combination with LT administered to HCD-fed rat groups. Hypercholesterolemia considerably induced the lipid peroxidation product, thiobarbituric acid reaction substances (TBARs), and oxidative radicals in cardiac cells, which were attenuated by QT and LT treatments, particularly when combined. Finally, QT, LT, and their combination were able to reduce the histological changes changes brought on by cholesterol excess in cardiac tissues. In conclusion, administration of TQ in a combination with LT which has a better protective effect, significantly reduced the hypercholesterolemic-induced oxidative and inflammatory changes that occurred in cardiac tissue. MDPI 2022-12-01 /pmc/articles/PMC9782872/ /pubmed/36547425 http://dx.doi.org/10.3390/jcdd9120428 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Al-Oanzi, Ziad H.
Alenazy, Fawaz O.
Alhassan, Hassan H.
El-Aassar, Mohamed R.
Alzarea, Abdulaziz I.
Alzarea, Sami I.
Abbas, Anass M.
Alanazi, Muteb H.
Al-Enazi, Maher M.
Effects of Thymoquinone Alone or in Combination with Losartan on the Cardiotoxicity Caused by Oxidative Stress and Inflammation in Hypercholesterolemia
title Effects of Thymoquinone Alone or in Combination with Losartan on the Cardiotoxicity Caused by Oxidative Stress and Inflammation in Hypercholesterolemia
title_full Effects of Thymoquinone Alone or in Combination with Losartan on the Cardiotoxicity Caused by Oxidative Stress and Inflammation in Hypercholesterolemia
title_fullStr Effects of Thymoquinone Alone or in Combination with Losartan on the Cardiotoxicity Caused by Oxidative Stress and Inflammation in Hypercholesterolemia
title_full_unstemmed Effects of Thymoquinone Alone or in Combination with Losartan on the Cardiotoxicity Caused by Oxidative Stress and Inflammation in Hypercholesterolemia
title_short Effects of Thymoquinone Alone or in Combination with Losartan on the Cardiotoxicity Caused by Oxidative Stress and Inflammation in Hypercholesterolemia
title_sort effects of thymoquinone alone or in combination with losartan on the cardiotoxicity caused by oxidative stress and inflammation in hypercholesterolemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782872/
https://www.ncbi.nlm.nih.gov/pubmed/36547425
http://dx.doi.org/10.3390/jcdd9120428
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