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Optimizing Biodegradable Starch-Based Composite Films Formulation for Wound-Dressing Applications

This paper utilizes response surface methodology (RSM) design-based analyses to optimize starch-based wound dressings that were characterized based on weight loss (WL%), swelling index (SI%), and mechanical strength (TS). The wound-dressing materials were prepared by employing a modified casting met...

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Autores principales: Delavari, Mohammad Mohsen, Ocampo, Ixchel, Stiharu, Ion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782896/
https://www.ncbi.nlm.nih.gov/pubmed/36557445
http://dx.doi.org/10.3390/mi13122146
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author Delavari, Mohammad Mohsen
Ocampo, Ixchel
Stiharu, Ion
author_facet Delavari, Mohammad Mohsen
Ocampo, Ixchel
Stiharu, Ion
author_sort Delavari, Mohammad Mohsen
collection PubMed
description This paper utilizes response surface methodology (RSM) design-based analyses to optimize starch-based wound dressings that were characterized based on weight loss (WL%), swelling index (SI%), and mechanical strength (TS). The wound-dressing materials were prepared by employing a modified casting method, using various concentrations of starch (0.5–2 w/w%), polyvinyl alcohol (PVA) (0.5–2 weight%), citric acid (1.5–4 weight%), and glycerol (1.5–4 weight%) to yield wound-dressing films with appropriate combinations of in vitro degradation, swelling index, and tensile strength. As a result of the response surface method-based analysis, the swelling index, in vitro degradation, and tensile strength were linearly related to variations in the formulation of organic components. Based on our experimental investigations, the optimized film (formulation: 1 weight% PVA, 2 weight% starch, 1.5 weight% citric acid, and 1.5 weight% glycerol) exhibited an outstanding swelling index (343.52%), suitable in vitro degradation (53.22%), and excellent tensile strength (8.82 MPa). The response surface plots for the dependent variables, swelling index (SI%), weight loss (WL%), and mechanical strength (TS), showed that in all dual relations, the PVA-starch combination significantly affected all dependent variables; however, the PVA-citric acid interaction showed the most excellent effect on the swelling index. As a result, every component of the resulting film had a lesser amount of all ingredients to achieve better properties at a lower material cost. Starch-based/PVA films have been identified in this paper as optimal and more affordable wound-dressing films.
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spelling pubmed-97828962022-12-24 Optimizing Biodegradable Starch-Based Composite Films Formulation for Wound-Dressing Applications Delavari, Mohammad Mohsen Ocampo, Ixchel Stiharu, Ion Micromachines (Basel) Article This paper utilizes response surface methodology (RSM) design-based analyses to optimize starch-based wound dressings that were characterized based on weight loss (WL%), swelling index (SI%), and mechanical strength (TS). The wound-dressing materials were prepared by employing a modified casting method, using various concentrations of starch (0.5–2 w/w%), polyvinyl alcohol (PVA) (0.5–2 weight%), citric acid (1.5–4 weight%), and glycerol (1.5–4 weight%) to yield wound-dressing films with appropriate combinations of in vitro degradation, swelling index, and tensile strength. As a result of the response surface method-based analysis, the swelling index, in vitro degradation, and tensile strength were linearly related to variations in the formulation of organic components. Based on our experimental investigations, the optimized film (formulation: 1 weight% PVA, 2 weight% starch, 1.5 weight% citric acid, and 1.5 weight% glycerol) exhibited an outstanding swelling index (343.52%), suitable in vitro degradation (53.22%), and excellent tensile strength (8.82 MPa). The response surface plots for the dependent variables, swelling index (SI%), weight loss (WL%), and mechanical strength (TS), showed that in all dual relations, the PVA-starch combination significantly affected all dependent variables; however, the PVA-citric acid interaction showed the most excellent effect on the swelling index. As a result, every component of the resulting film had a lesser amount of all ingredients to achieve better properties at a lower material cost. Starch-based/PVA films have been identified in this paper as optimal and more affordable wound-dressing films. MDPI 2022-12-04 /pmc/articles/PMC9782896/ /pubmed/36557445 http://dx.doi.org/10.3390/mi13122146 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Delavari, Mohammad Mohsen
Ocampo, Ixchel
Stiharu, Ion
Optimizing Biodegradable Starch-Based Composite Films Formulation for Wound-Dressing Applications
title Optimizing Biodegradable Starch-Based Composite Films Formulation for Wound-Dressing Applications
title_full Optimizing Biodegradable Starch-Based Composite Films Formulation for Wound-Dressing Applications
title_fullStr Optimizing Biodegradable Starch-Based Composite Films Formulation for Wound-Dressing Applications
title_full_unstemmed Optimizing Biodegradable Starch-Based Composite Films Formulation for Wound-Dressing Applications
title_short Optimizing Biodegradable Starch-Based Composite Films Formulation for Wound-Dressing Applications
title_sort optimizing biodegradable starch-based composite films formulation for wound-dressing applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782896/
https://www.ncbi.nlm.nih.gov/pubmed/36557445
http://dx.doi.org/10.3390/mi13122146
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