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Liver collision tumor of primary hepatocellular carcinoma and neuroendocrine carcinoma: A rare case report

BACKGROUND: Hepatocellular carcinoma (HCC) can occasionally develop with other non-HCC cell types, either in a combined type or collision type. A collision tumor is defined as two histopathologically distinct tumors of the same organ lacking a clear transition zone. Hepatic collision tumors are rare...

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Autores principales: Jeng, Kuo-Shyang, Huang, Chun-Chieh, Chung, Chen-Shuan, Chang, Chiung-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782927/
https://www.ncbi.nlm.nih.gov/pubmed/36569002
http://dx.doi.org/10.12998/wjcc.v10.i35.13129
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author Jeng, Kuo-Shyang
Huang, Chun-Chieh
Chung, Chen-Shuan
Chang, Chiung-Fang
author_facet Jeng, Kuo-Shyang
Huang, Chun-Chieh
Chung, Chen-Shuan
Chang, Chiung-Fang
author_sort Jeng, Kuo-Shyang
collection PubMed
description BACKGROUND: Hepatocellular carcinoma (HCC) can occasionally develop with other non-HCC cell types, either in a combined type or collision type. A collision tumor is defined as two histopathologically distinct tumors of the same organ lacking a clear transition zone. Hepatic collision tumors are rare. Among them, “hepatocellular carcinoma-hepatic neuroendocrine carcinoma” (HCC-NEC) collision tumors are especially rare and information about them is rarely published. CASE SUMMARY: A 48-year-old man with typical findings of HCC underwent consecutive therapies, including radiofrequency ablation and embolization prior to resection. Diagnosis of the HCC-NEC collision tumor in the right liver and another HCC in the left liver was established following surgical resection. The patient displayed NEC metastasis following resection and succumbed to septicemia after 2 more rounds of chemotherapy. To our knowledge, this is the 25(th )reported case of mixed HCC-NEC tumor. The rarity of HCC-NEC collision tumors and the absence of diagnostic criteria make it difficult to differentiate this condition from simple liver tumors, especially in patients with chronic liver disease. CONCLUSION: Our case highlights the difficulty in accurately diagnosing HCC-NEC in the absence of histological evidence. The prognosis is poor for this condition, although ultrasound-guided liver biopsy can be helpful to establish a prompt diagnosis. Further accumulation of such cases could help establish an accurate diagnosis earlier. Early discovery of NEC may allow for better treatment strategies and better prognoses.
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spelling pubmed-97829272022-12-24 Liver collision tumor of primary hepatocellular carcinoma and neuroendocrine carcinoma: A rare case report Jeng, Kuo-Shyang Huang, Chun-Chieh Chung, Chen-Shuan Chang, Chiung-Fang World J Clin Cases Case Report BACKGROUND: Hepatocellular carcinoma (HCC) can occasionally develop with other non-HCC cell types, either in a combined type or collision type. A collision tumor is defined as two histopathologically distinct tumors of the same organ lacking a clear transition zone. Hepatic collision tumors are rare. Among them, “hepatocellular carcinoma-hepatic neuroendocrine carcinoma” (HCC-NEC) collision tumors are especially rare and information about them is rarely published. CASE SUMMARY: A 48-year-old man with typical findings of HCC underwent consecutive therapies, including radiofrequency ablation and embolization prior to resection. Diagnosis of the HCC-NEC collision tumor in the right liver and another HCC in the left liver was established following surgical resection. The patient displayed NEC metastasis following resection and succumbed to septicemia after 2 more rounds of chemotherapy. To our knowledge, this is the 25(th )reported case of mixed HCC-NEC tumor. The rarity of HCC-NEC collision tumors and the absence of diagnostic criteria make it difficult to differentiate this condition from simple liver tumors, especially in patients with chronic liver disease. CONCLUSION: Our case highlights the difficulty in accurately diagnosing HCC-NEC in the absence of histological evidence. The prognosis is poor for this condition, although ultrasound-guided liver biopsy can be helpful to establish a prompt diagnosis. Further accumulation of such cases could help establish an accurate diagnosis earlier. Early discovery of NEC may allow for better treatment strategies and better prognoses. Baishideng Publishing Group Inc 2022-12-16 2022-12-16 /pmc/articles/PMC9782927/ /pubmed/36569002 http://dx.doi.org/10.12998/wjcc.v10.i35.13129 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Case Report
Jeng, Kuo-Shyang
Huang, Chun-Chieh
Chung, Chen-Shuan
Chang, Chiung-Fang
Liver collision tumor of primary hepatocellular carcinoma and neuroendocrine carcinoma: A rare case report
title Liver collision tumor of primary hepatocellular carcinoma and neuroendocrine carcinoma: A rare case report
title_full Liver collision tumor of primary hepatocellular carcinoma and neuroendocrine carcinoma: A rare case report
title_fullStr Liver collision tumor of primary hepatocellular carcinoma and neuroendocrine carcinoma: A rare case report
title_full_unstemmed Liver collision tumor of primary hepatocellular carcinoma and neuroendocrine carcinoma: A rare case report
title_short Liver collision tumor of primary hepatocellular carcinoma and neuroendocrine carcinoma: A rare case report
title_sort liver collision tumor of primary hepatocellular carcinoma and neuroendocrine carcinoma: a rare case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782927/
https://www.ncbi.nlm.nih.gov/pubmed/36569002
http://dx.doi.org/10.12998/wjcc.v10.i35.13129
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AT chungchenshuan livercollisiontumorofprimaryhepatocellularcarcinomaandneuroendocrinecarcinomaararecasereport
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