Real role of growth factor receptor-binding protein 10: Linking lipid metabolism to diabetes cardiovascular complications

Cardiovascular complications of patients with type 2 diabetes mellitus (T2DM) threaten the health and life of numerous individuals. Recently, growth factor receptor-binding protein 10 (GRB10) was found to play a pivotal role in vascular complications of T2DM, which participates in the regulation of...

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Autores principales: Yang, Yang, Yao, Hua-Jie, Lin, Wei-Jie, Huang, Si-Chao, Li, Xiao-Dong, He, Fa-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782935/
https://www.ncbi.nlm.nih.gov/pubmed/36569013
http://dx.doi.org/10.12998/wjcc.v10.i35.12875
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author Yang, Yang
Yao, Hua-Jie
Lin, Wei-Jie
Huang, Si-Chao
Li, Xiao-Dong
He, Fa-Zhong
author_facet Yang, Yang
Yao, Hua-Jie
Lin, Wei-Jie
Huang, Si-Chao
Li, Xiao-Dong
He, Fa-Zhong
author_sort Yang, Yang
collection PubMed
description Cardiovascular complications of patients with type 2 diabetes mellitus (T2DM) threaten the health and life of numerous individuals. Recently, growth factor receptor-binding protein 10 (GRB10) was found to play a pivotal role in vascular complications of T2DM, which participates in the regulation of lipid metabolism of T2DM patients. The genetic variation of GRB10 rs1800504 is closely related to the risk of coronary heart disease in patients with T2DM. The development of GRB10 as a key mediator in the association of lipid metabolism with cardiovascular complications in T2DM is detailed in and may provide new potential concerns for the study of cardiovascular complications in T2DM patients.
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spelling pubmed-97829352022-12-24 Real role of growth factor receptor-binding protein 10: Linking lipid metabolism to diabetes cardiovascular complications Yang, Yang Yao, Hua-Jie Lin, Wei-Jie Huang, Si-Chao Li, Xiao-Dong He, Fa-Zhong World J Clin Cases Minireviews Cardiovascular complications of patients with type 2 diabetes mellitus (T2DM) threaten the health and life of numerous individuals. Recently, growth factor receptor-binding protein 10 (GRB10) was found to play a pivotal role in vascular complications of T2DM, which participates in the regulation of lipid metabolism of T2DM patients. The genetic variation of GRB10 rs1800504 is closely related to the risk of coronary heart disease in patients with T2DM. The development of GRB10 as a key mediator in the association of lipid metabolism with cardiovascular complications in T2DM is detailed in and may provide new potential concerns for the study of cardiovascular complications in T2DM patients. Baishideng Publishing Group Inc 2022-12-16 2022-12-16 /pmc/articles/PMC9782935/ /pubmed/36569013 http://dx.doi.org/10.12998/wjcc.v10.i35.12875 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Minireviews
Yang, Yang
Yao, Hua-Jie
Lin, Wei-Jie
Huang, Si-Chao
Li, Xiao-Dong
He, Fa-Zhong
Real role of growth factor receptor-binding protein 10: Linking lipid metabolism to diabetes cardiovascular complications
title Real role of growth factor receptor-binding protein 10: Linking lipid metabolism to diabetes cardiovascular complications
title_full Real role of growth factor receptor-binding protein 10: Linking lipid metabolism to diabetes cardiovascular complications
title_fullStr Real role of growth factor receptor-binding protein 10: Linking lipid metabolism to diabetes cardiovascular complications
title_full_unstemmed Real role of growth factor receptor-binding protein 10: Linking lipid metabolism to diabetes cardiovascular complications
title_short Real role of growth factor receptor-binding protein 10: Linking lipid metabolism to diabetes cardiovascular complications
title_sort real role of growth factor receptor-binding protein 10: linking lipid metabolism to diabetes cardiovascular complications
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782935/
https://www.ncbi.nlm.nih.gov/pubmed/36569013
http://dx.doi.org/10.12998/wjcc.v10.i35.12875
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