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Systemic combined with intravitreal methotrexate for relentless placoid chorioretinitis: A case report

BACKGROUND: We describe a case of relentless placoid chorioretinitis (RPC) that progressed despite administration of peribulbar and systemic corticosteroids, and was resolved by systemic combined with intravitreal methotrexate. CASE SUMMARY: A 16-year-old male reported painless blurred vision and a...

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Autores principales: Luo, Lan, Chen, Wei-Bin, Zhao, Ming-Wei, Miao, Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782938/
https://www.ncbi.nlm.nih.gov/pubmed/36569015
http://dx.doi.org/10.12998/wjcc.v10.i35.13115
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author Luo, Lan
Chen, Wei-Bin
Zhao, Ming-Wei
Miao, Heng
author_facet Luo, Lan
Chen, Wei-Bin
Zhao, Ming-Wei
Miao, Heng
author_sort Luo, Lan
collection PubMed
description BACKGROUND: We describe a case of relentless placoid chorioretinitis (RPC) that progressed despite administration of peribulbar and systemic corticosteroids, and was resolved by systemic combined with intravitreal methotrexate. CASE SUMMARY: A 16-year-old male reported painless blurred vision and a temporal scotoma in his right eye for one week. Due to widespread distribution and continuous enlargement, multimodal imaging of the lesions led to the diagnosis of RPC. Lesions in the right eye extended despite peribulbar injection of triamcinolone acetonide, but the progression was immediately terminated by a single dose of intravitreal methotrexate. A new fresh lesion occurred in the contralateral eye despite systemic prednisolone but was resolved by oral methotrexate. CONCLUSION: Systemic immunosuppressants should be given upon RPC diagnosis. Intravitreal methotrexate immediately halted progression and may be considered for sight-threatening cases as part of the initial therapy.
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spelling pubmed-97829382022-12-24 Systemic combined with intravitreal methotrexate for relentless placoid chorioretinitis: A case report Luo, Lan Chen, Wei-Bin Zhao, Ming-Wei Miao, Heng World J Clin Cases Case Report BACKGROUND: We describe a case of relentless placoid chorioretinitis (RPC) that progressed despite administration of peribulbar and systemic corticosteroids, and was resolved by systemic combined with intravitreal methotrexate. CASE SUMMARY: A 16-year-old male reported painless blurred vision and a temporal scotoma in his right eye for one week. Due to widespread distribution and continuous enlargement, multimodal imaging of the lesions led to the diagnosis of RPC. Lesions in the right eye extended despite peribulbar injection of triamcinolone acetonide, but the progression was immediately terminated by a single dose of intravitreal methotrexate. A new fresh lesion occurred in the contralateral eye despite systemic prednisolone but was resolved by oral methotrexate. CONCLUSION: Systemic immunosuppressants should be given upon RPC diagnosis. Intravitreal methotrexate immediately halted progression and may be considered for sight-threatening cases as part of the initial therapy. Baishideng Publishing Group Inc 2022-12-16 2022-12-16 /pmc/articles/PMC9782938/ /pubmed/36569015 http://dx.doi.org/10.12998/wjcc.v10.i35.13115 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Case Report
Luo, Lan
Chen, Wei-Bin
Zhao, Ming-Wei
Miao, Heng
Systemic combined with intravitreal methotrexate for relentless placoid chorioretinitis: A case report
title Systemic combined with intravitreal methotrexate for relentless placoid chorioretinitis: A case report
title_full Systemic combined with intravitreal methotrexate for relentless placoid chorioretinitis: A case report
title_fullStr Systemic combined with intravitreal methotrexate for relentless placoid chorioretinitis: A case report
title_full_unstemmed Systemic combined with intravitreal methotrexate for relentless placoid chorioretinitis: A case report
title_short Systemic combined with intravitreal methotrexate for relentless placoid chorioretinitis: A case report
title_sort systemic combined with intravitreal methotrexate for relentless placoid chorioretinitis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782938/
https://www.ncbi.nlm.nih.gov/pubmed/36569015
http://dx.doi.org/10.12998/wjcc.v10.i35.13115
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