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Sex-Specific Associations of Red Meat and Processed Meat Consumption with Serum Metabolites in the UK Biobank

Red meat consumption has been found to closely related to cardiometabolic health, with sex disparity. However, the specific metabolic factors corresponding to red meat consumption in men and women have not been examined previously. We analyzed the sex-specific associations of meat consumption, with...

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Autores principales: Fan, Bohan, Zhao, Jie V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782977/
https://www.ncbi.nlm.nih.gov/pubmed/36558463
http://dx.doi.org/10.3390/nu14245306
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author Fan, Bohan
Zhao, Jie V.
author_facet Fan, Bohan
Zhao, Jie V.
author_sort Fan, Bohan
collection PubMed
description Red meat consumption has been found to closely related to cardiometabolic health, with sex disparity. However, the specific metabolic factors corresponding to red meat consumption in men and women have not been examined previously. We analyzed the sex-specific associations of meat consumption, with 167 metabolites using multivariable regression, controlling for age, ethnicity, Townsend deprivation index, education, physical activity, smoking, and drinking status among ~79,644 UK Biobank participants. We also compared the sex differences using an established formula. After accounting for multiple testing with false discovery rate < 5% and controlling for confounders, the positive associations of unprocessed red meat consumption with branched-chain amino acids and several lipoproteins, and the inverse association with glycine were stronger in women, while the positive associations with apolipoprotein A1, creatinine, and monounsaturated fatty acids were more obvious in men. For processed meat, the positive associations with branched-chain amino acids, several lipoproteins, tyrosine, lactate, glycoprotein acetyls and inverse associations with glutamine, and glycine were stronger in women than in men. The study suggests that meat consumption has sex-specific associations with several metabolites. This has important implication to provide dietary suggestions for individuals with or at high risk of cardiometabolic disease, with consideration of sex difference.
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spelling pubmed-97829772022-12-24 Sex-Specific Associations of Red Meat and Processed Meat Consumption with Serum Metabolites in the UK Biobank Fan, Bohan Zhao, Jie V. Nutrients Article Red meat consumption has been found to closely related to cardiometabolic health, with sex disparity. However, the specific metabolic factors corresponding to red meat consumption in men and women have not been examined previously. We analyzed the sex-specific associations of meat consumption, with 167 metabolites using multivariable regression, controlling for age, ethnicity, Townsend deprivation index, education, physical activity, smoking, and drinking status among ~79,644 UK Biobank participants. We also compared the sex differences using an established formula. After accounting for multiple testing with false discovery rate < 5% and controlling for confounders, the positive associations of unprocessed red meat consumption with branched-chain amino acids and several lipoproteins, and the inverse association with glycine were stronger in women, while the positive associations with apolipoprotein A1, creatinine, and monounsaturated fatty acids were more obvious in men. For processed meat, the positive associations with branched-chain amino acids, several lipoproteins, tyrosine, lactate, glycoprotein acetyls and inverse associations with glutamine, and glycine were stronger in women than in men. The study suggests that meat consumption has sex-specific associations with several metabolites. This has important implication to provide dietary suggestions for individuals with or at high risk of cardiometabolic disease, with consideration of sex difference. MDPI 2022-12-14 /pmc/articles/PMC9782977/ /pubmed/36558463 http://dx.doi.org/10.3390/nu14245306 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fan, Bohan
Zhao, Jie V.
Sex-Specific Associations of Red Meat and Processed Meat Consumption with Serum Metabolites in the UK Biobank
title Sex-Specific Associations of Red Meat and Processed Meat Consumption with Serum Metabolites in the UK Biobank
title_full Sex-Specific Associations of Red Meat and Processed Meat Consumption with Serum Metabolites in the UK Biobank
title_fullStr Sex-Specific Associations of Red Meat and Processed Meat Consumption with Serum Metabolites in the UK Biobank
title_full_unstemmed Sex-Specific Associations of Red Meat and Processed Meat Consumption with Serum Metabolites in the UK Biobank
title_short Sex-Specific Associations of Red Meat and Processed Meat Consumption with Serum Metabolites in the UK Biobank
title_sort sex-specific associations of red meat and processed meat consumption with serum metabolites in the uk biobank
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782977/
https://www.ncbi.nlm.nih.gov/pubmed/36558463
http://dx.doi.org/10.3390/nu14245306
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