Combined nasal- and oropharyngeal self-swab provides equivalent performance compared to professionally collected oropharyngeal swabs in detecting SARS-CoV-2 in a real-life setting

PURPOSE: To investigate the performance of a combined nasal midturbinate- and oropharyngeal (NAOP) self-swab compared to a deep oropharyngeal (OP) swab by health care workers (HCW) in detecting SARS-CoV-2 in a real-life setting. METHODS: Paired swabs from 1119 participants were included. RT-PCR were...

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Autores principales: Hørlyck, Sofie, Nielsen, Sofie Holdflod, Gress, Tobias, Schneider, Uffe, Martel, Cyril Jean-Marie, Steenhard, Nina, Gredal, Niels Tobias, Mortensen, Shila, Cohen, Arieh S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783189/
https://www.ncbi.nlm.nih.gov/pubmed/36572155
http://dx.doi.org/10.1016/j.jviromet.2022.114667
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author Hørlyck, Sofie
Nielsen, Sofie Holdflod
Gress, Tobias
Schneider, Uffe
Martel, Cyril Jean-Marie
Steenhard, Nina
Gredal, Niels Tobias
Mortensen, Shila
Cohen, Arieh S.
author_facet Hørlyck, Sofie
Nielsen, Sofie Holdflod
Gress, Tobias
Schneider, Uffe
Martel, Cyril Jean-Marie
Steenhard, Nina
Gredal, Niels Tobias
Mortensen, Shila
Cohen, Arieh S.
author_sort Hørlyck, Sofie
collection PubMed
description PURPOSE: To investigate the performance of a combined nasal midturbinate- and oropharyngeal (NAOP) self-swab compared to a deep oropharyngeal (OP) swab by health care workers (HCW) in detecting SARS-CoV-2 in a real-life setting. METHODS: Paired swabs from 1119 participants were included. RT-PCR were used to detect SARS-CoV-2 in both swab samples. RESULTS: 330 participants tested positive. The sensitivity of the combined self-swab and OP swab was 96.9 % and 95.4 % respectively, whereas the Ct-values for self-swabs were significantly lower compared to OP swabs. CONCLUSION: The combined NAOP self-swab outperformed the OP swab and thus, the NAOP self-swab may be an alternative sampling method under the given circumstances.
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spelling pubmed-97831892022-12-23 Combined nasal- and oropharyngeal self-swab provides equivalent performance compared to professionally collected oropharyngeal swabs in detecting SARS-CoV-2 in a real-life setting Hørlyck, Sofie Nielsen, Sofie Holdflod Gress, Tobias Schneider, Uffe Martel, Cyril Jean-Marie Steenhard, Nina Gredal, Niels Tobias Mortensen, Shila Cohen, Arieh S. J Virol Methods Article PURPOSE: To investigate the performance of a combined nasal midturbinate- and oropharyngeal (NAOP) self-swab compared to a deep oropharyngeal (OP) swab by health care workers (HCW) in detecting SARS-CoV-2 in a real-life setting. METHODS: Paired swabs from 1119 participants were included. RT-PCR were used to detect SARS-CoV-2 in both swab samples. RESULTS: 330 participants tested positive. The sensitivity of the combined self-swab and OP swab was 96.9 % and 95.4 % respectively, whereas the Ct-values for self-swabs were significantly lower compared to OP swabs. CONCLUSION: The combined NAOP self-swab outperformed the OP swab and thus, the NAOP self-swab may be an alternative sampling method under the given circumstances. The Authors. Published by Elsevier B.V. 2023-03 2022-12-23 /pmc/articles/PMC9783189/ /pubmed/36572155 http://dx.doi.org/10.1016/j.jviromet.2022.114667 Text en © 2023 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Hørlyck, Sofie
Nielsen, Sofie Holdflod
Gress, Tobias
Schneider, Uffe
Martel, Cyril Jean-Marie
Steenhard, Nina
Gredal, Niels Tobias
Mortensen, Shila
Cohen, Arieh S.
Combined nasal- and oropharyngeal self-swab provides equivalent performance compared to professionally collected oropharyngeal swabs in detecting SARS-CoV-2 in a real-life setting
title Combined nasal- and oropharyngeal self-swab provides equivalent performance compared to professionally collected oropharyngeal swabs in detecting SARS-CoV-2 in a real-life setting
title_full Combined nasal- and oropharyngeal self-swab provides equivalent performance compared to professionally collected oropharyngeal swabs in detecting SARS-CoV-2 in a real-life setting
title_fullStr Combined nasal- and oropharyngeal self-swab provides equivalent performance compared to professionally collected oropharyngeal swabs in detecting SARS-CoV-2 in a real-life setting
title_full_unstemmed Combined nasal- and oropharyngeal self-swab provides equivalent performance compared to professionally collected oropharyngeal swabs in detecting SARS-CoV-2 in a real-life setting
title_short Combined nasal- and oropharyngeal self-swab provides equivalent performance compared to professionally collected oropharyngeal swabs in detecting SARS-CoV-2 in a real-life setting
title_sort combined nasal- and oropharyngeal self-swab provides equivalent performance compared to professionally collected oropharyngeal swabs in detecting sars-cov-2 in a real-life setting
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783189/
https://www.ncbi.nlm.nih.gov/pubmed/36572155
http://dx.doi.org/10.1016/j.jviromet.2022.114667
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