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Persistent Inflammation in Cerebral Palsy: Pathogenic Mediator or Comorbidity? A Scoping Review

Research has established inflammation in the pathogenesis of brain injury and the risk of developing cerebral palsy (CP). However, it is unclear if inflammation is solely pathogenic and primarily contributes to the acute phase of injury, or if inflammation persists with consequence in CP and may the...

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Autores principales: Paton, Madison C. B., Finch-Edmondson, Megan, Dale, Russell C., Fahey, Michael C., Nold-Petry, Claudia A., Nold, Marcel F., Griffin, Alexandra R., Novak, Iona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783203/
https://www.ncbi.nlm.nih.gov/pubmed/36555983
http://dx.doi.org/10.3390/jcm11247368
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author Paton, Madison C. B.
Finch-Edmondson, Megan
Dale, Russell C.
Fahey, Michael C.
Nold-Petry, Claudia A.
Nold, Marcel F.
Griffin, Alexandra R.
Novak, Iona
author_facet Paton, Madison C. B.
Finch-Edmondson, Megan
Dale, Russell C.
Fahey, Michael C.
Nold-Petry, Claudia A.
Nold, Marcel F.
Griffin, Alexandra R.
Novak, Iona
author_sort Paton, Madison C. B.
collection PubMed
description Research has established inflammation in the pathogenesis of brain injury and the risk of developing cerebral palsy (CP). However, it is unclear if inflammation is solely pathogenic and primarily contributes to the acute phase of injury, or if inflammation persists with consequence in CP and may therefore be considered a comorbidity. We conducted a scoping review to identify studies that analyzed inflammatory biomarkers in CP and discuss the role of inflammation in the pathogenesis of CP and/or as a comorbidity. Twelve included studies reported a range of analytes, methods and biomarkers, including indicators of inflammatory status, immune function and genetic changes. The majority of controlled studies concluded that one or more systemic biomarkers of inflammation were significantly different in CP versus controls; most commonly serum or plasma cytokines such as tumor necrosis factor, Interleukin (IL)-6 and IL-10. In addition, differences in inflammation were noted in distinct subgroups of CP (e.g., those with varying severity). The available evidence supports the pathogenic role of inflammation and its ongoing role as a comorbidity of CP. This review shows that inflammation may persist for decades, driving functional impairment across development and into adulthood. However, inflammation is complex, thus further research will increase our understanding.
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spelling pubmed-97832032022-12-24 Persistent Inflammation in Cerebral Palsy: Pathogenic Mediator or Comorbidity? A Scoping Review Paton, Madison C. B. Finch-Edmondson, Megan Dale, Russell C. Fahey, Michael C. Nold-Petry, Claudia A. Nold, Marcel F. Griffin, Alexandra R. Novak, Iona J Clin Med Review Research has established inflammation in the pathogenesis of brain injury and the risk of developing cerebral palsy (CP). However, it is unclear if inflammation is solely pathogenic and primarily contributes to the acute phase of injury, or if inflammation persists with consequence in CP and may therefore be considered a comorbidity. We conducted a scoping review to identify studies that analyzed inflammatory biomarkers in CP and discuss the role of inflammation in the pathogenesis of CP and/or as a comorbidity. Twelve included studies reported a range of analytes, methods and biomarkers, including indicators of inflammatory status, immune function and genetic changes. The majority of controlled studies concluded that one or more systemic biomarkers of inflammation were significantly different in CP versus controls; most commonly serum or plasma cytokines such as tumor necrosis factor, Interleukin (IL)-6 and IL-10. In addition, differences in inflammation were noted in distinct subgroups of CP (e.g., those with varying severity). The available evidence supports the pathogenic role of inflammation and its ongoing role as a comorbidity of CP. This review shows that inflammation may persist for decades, driving functional impairment across development and into adulthood. However, inflammation is complex, thus further research will increase our understanding. MDPI 2022-12-12 /pmc/articles/PMC9783203/ /pubmed/36555983 http://dx.doi.org/10.3390/jcm11247368 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Paton, Madison C. B.
Finch-Edmondson, Megan
Dale, Russell C.
Fahey, Michael C.
Nold-Petry, Claudia A.
Nold, Marcel F.
Griffin, Alexandra R.
Novak, Iona
Persistent Inflammation in Cerebral Palsy: Pathogenic Mediator or Comorbidity? A Scoping Review
title Persistent Inflammation in Cerebral Palsy: Pathogenic Mediator or Comorbidity? A Scoping Review
title_full Persistent Inflammation in Cerebral Palsy: Pathogenic Mediator or Comorbidity? A Scoping Review
title_fullStr Persistent Inflammation in Cerebral Palsy: Pathogenic Mediator or Comorbidity? A Scoping Review
title_full_unstemmed Persistent Inflammation in Cerebral Palsy: Pathogenic Mediator or Comorbidity? A Scoping Review
title_short Persistent Inflammation in Cerebral Palsy: Pathogenic Mediator or Comorbidity? A Scoping Review
title_sort persistent inflammation in cerebral palsy: pathogenic mediator or comorbidity? a scoping review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783203/
https://www.ncbi.nlm.nih.gov/pubmed/36555983
http://dx.doi.org/10.3390/jcm11247368
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