Cargando…

NT-pro-BNP as a Predictor for Recurrence of Atrial Fibrillation after Primary Cryoballoon Pulmonary Vein Isolation

NT-pro-BNP is produced in the cardiac atria and ventricles in response to increased wall stress. It may be a marker of both AF disease progression and co-morbidities that affect success after pulmonary vein isolation (PVI). This single-center retrospective study analyzed the association between pre-...

Descripción completa

Detalles Bibliográficos
Autores principales: Blessberger, Hermann, Lambert, Thomas, Nahler, Alexander, Hrncic, Denis, Hönig, Simon, Maier, Julian, Rechberger, Stefan, Windhager, Armin, Reiter, Christian, Kellermair, Joerg, Kammler, Juergen, Wagner, Helga, Steinwender, Clemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783297/
https://www.ncbi.nlm.nih.gov/pubmed/36556020
http://dx.doi.org/10.3390/jcm11247400
_version_ 1784857544755249152
author Blessberger, Hermann
Lambert, Thomas
Nahler, Alexander
Hrncic, Denis
Hönig, Simon
Maier, Julian
Rechberger, Stefan
Windhager, Armin
Reiter, Christian
Kellermair, Joerg
Kammler, Juergen
Wagner, Helga
Steinwender, Clemens
author_facet Blessberger, Hermann
Lambert, Thomas
Nahler, Alexander
Hrncic, Denis
Hönig, Simon
Maier, Julian
Rechberger, Stefan
Windhager, Armin
Reiter, Christian
Kellermair, Joerg
Kammler, Juergen
Wagner, Helga
Steinwender, Clemens
author_sort Blessberger, Hermann
collection PubMed
description NT-pro-BNP is produced in the cardiac atria and ventricles in response to increased wall stress. It may be a marker of both AF disease progression and co-morbidities that affect success after pulmonary vein isolation (PVI). This single-center retrospective study analyzed the association between pre-procedural NT-pro-BNP serum levels and the long-term outcome after a first-ever PVI in cryo-technique. Patients were followed by searching the hospital information system and conducting structured telephone interviews. Treatment failure was defined as any relapse of atrial fibrillation (AF) occurring 90 days after the index PVI at the earliest. Kaplan–Meier survival curves and Cox proportional hazards models were computed to assess the impact of NT-pro-BNP on AF recurrence. Following 374 patients over a median of 3.8 years (range: 0.25–9.4 years), baseline NT-pro-BNP was associated with the combined endpoint in univariate analysis (HR 1.04 per 100 pg/mL increase, 95% CI: 1.02–1.07, p < 0.001). Results were virtually unchanged in the multivariate model or if the data were log-transformed. Intraprocedural left atrial pressure correlated positively with log NT-pro-BNP. NT-pro-BNP was associated with AF relapse during a long-term follow-up after first-ever cryo-PVI in our cohort of patients with predominantly normal left ventricular function. This lab parameter is easy to obtain and has significant potential to guide treatment decisions.
format Online
Article
Text
id pubmed-9783297
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97832972022-12-24 NT-pro-BNP as a Predictor for Recurrence of Atrial Fibrillation after Primary Cryoballoon Pulmonary Vein Isolation Blessberger, Hermann Lambert, Thomas Nahler, Alexander Hrncic, Denis Hönig, Simon Maier, Julian Rechberger, Stefan Windhager, Armin Reiter, Christian Kellermair, Joerg Kammler, Juergen Wagner, Helga Steinwender, Clemens J Clin Med Article NT-pro-BNP is produced in the cardiac atria and ventricles in response to increased wall stress. It may be a marker of both AF disease progression and co-morbidities that affect success after pulmonary vein isolation (PVI). This single-center retrospective study analyzed the association between pre-procedural NT-pro-BNP serum levels and the long-term outcome after a first-ever PVI in cryo-technique. Patients were followed by searching the hospital information system and conducting structured telephone interviews. Treatment failure was defined as any relapse of atrial fibrillation (AF) occurring 90 days after the index PVI at the earliest. Kaplan–Meier survival curves and Cox proportional hazards models were computed to assess the impact of NT-pro-BNP on AF recurrence. Following 374 patients over a median of 3.8 years (range: 0.25–9.4 years), baseline NT-pro-BNP was associated with the combined endpoint in univariate analysis (HR 1.04 per 100 pg/mL increase, 95% CI: 1.02–1.07, p < 0.001). Results were virtually unchanged in the multivariate model or if the data were log-transformed. Intraprocedural left atrial pressure correlated positively with log NT-pro-BNP. NT-pro-BNP was associated with AF relapse during a long-term follow-up after first-ever cryo-PVI in our cohort of patients with predominantly normal left ventricular function. This lab parameter is easy to obtain and has significant potential to guide treatment decisions. MDPI 2022-12-14 /pmc/articles/PMC9783297/ /pubmed/36556020 http://dx.doi.org/10.3390/jcm11247400 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Blessberger, Hermann
Lambert, Thomas
Nahler, Alexander
Hrncic, Denis
Hönig, Simon
Maier, Julian
Rechberger, Stefan
Windhager, Armin
Reiter, Christian
Kellermair, Joerg
Kammler, Juergen
Wagner, Helga
Steinwender, Clemens
NT-pro-BNP as a Predictor for Recurrence of Atrial Fibrillation after Primary Cryoballoon Pulmonary Vein Isolation
title NT-pro-BNP as a Predictor for Recurrence of Atrial Fibrillation after Primary Cryoballoon Pulmonary Vein Isolation
title_full NT-pro-BNP as a Predictor for Recurrence of Atrial Fibrillation after Primary Cryoballoon Pulmonary Vein Isolation
title_fullStr NT-pro-BNP as a Predictor for Recurrence of Atrial Fibrillation after Primary Cryoballoon Pulmonary Vein Isolation
title_full_unstemmed NT-pro-BNP as a Predictor for Recurrence of Atrial Fibrillation after Primary Cryoballoon Pulmonary Vein Isolation
title_short NT-pro-BNP as a Predictor for Recurrence of Atrial Fibrillation after Primary Cryoballoon Pulmonary Vein Isolation
title_sort nt-pro-bnp as a predictor for recurrence of atrial fibrillation after primary cryoballoon pulmonary vein isolation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783297/
https://www.ncbi.nlm.nih.gov/pubmed/36556020
http://dx.doi.org/10.3390/jcm11247400
work_keys_str_mv AT blessbergerhermann ntprobnpasapredictorforrecurrenceofatrialfibrillationafterprimarycryoballoonpulmonaryveinisolation
AT lambertthomas ntprobnpasapredictorforrecurrenceofatrialfibrillationafterprimarycryoballoonpulmonaryveinisolation
AT nahleralexander ntprobnpasapredictorforrecurrenceofatrialfibrillationafterprimarycryoballoonpulmonaryveinisolation
AT hrncicdenis ntprobnpasapredictorforrecurrenceofatrialfibrillationafterprimarycryoballoonpulmonaryveinisolation
AT honigsimon ntprobnpasapredictorforrecurrenceofatrialfibrillationafterprimarycryoballoonpulmonaryveinisolation
AT maierjulian ntprobnpasapredictorforrecurrenceofatrialfibrillationafterprimarycryoballoonpulmonaryveinisolation
AT rechbergerstefan ntprobnpasapredictorforrecurrenceofatrialfibrillationafterprimarycryoballoonpulmonaryveinisolation
AT windhagerarmin ntprobnpasapredictorforrecurrenceofatrialfibrillationafterprimarycryoballoonpulmonaryveinisolation
AT reiterchristian ntprobnpasapredictorforrecurrenceofatrialfibrillationafterprimarycryoballoonpulmonaryveinisolation
AT kellermairjoerg ntprobnpasapredictorforrecurrenceofatrialfibrillationafterprimarycryoballoonpulmonaryveinisolation
AT kammlerjuergen ntprobnpasapredictorforrecurrenceofatrialfibrillationafterprimarycryoballoonpulmonaryveinisolation
AT wagnerhelga ntprobnpasapredictorforrecurrenceofatrialfibrillationafterprimarycryoballoonpulmonaryveinisolation
AT steinwenderclemens ntprobnpasapredictorforrecurrenceofatrialfibrillationafterprimarycryoballoonpulmonaryveinisolation