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NT-pro-BNP as a Predictor for Recurrence of Atrial Fibrillation after Primary Cryoballoon Pulmonary Vein Isolation
NT-pro-BNP is produced in the cardiac atria and ventricles in response to increased wall stress. It may be a marker of both AF disease progression and co-morbidities that affect success after pulmonary vein isolation (PVI). This single-center retrospective study analyzed the association between pre-...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783297/ https://www.ncbi.nlm.nih.gov/pubmed/36556020 http://dx.doi.org/10.3390/jcm11247400 |
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author | Blessberger, Hermann Lambert, Thomas Nahler, Alexander Hrncic, Denis Hönig, Simon Maier, Julian Rechberger, Stefan Windhager, Armin Reiter, Christian Kellermair, Joerg Kammler, Juergen Wagner, Helga Steinwender, Clemens |
author_facet | Blessberger, Hermann Lambert, Thomas Nahler, Alexander Hrncic, Denis Hönig, Simon Maier, Julian Rechberger, Stefan Windhager, Armin Reiter, Christian Kellermair, Joerg Kammler, Juergen Wagner, Helga Steinwender, Clemens |
author_sort | Blessberger, Hermann |
collection | PubMed |
description | NT-pro-BNP is produced in the cardiac atria and ventricles in response to increased wall stress. It may be a marker of both AF disease progression and co-morbidities that affect success after pulmonary vein isolation (PVI). This single-center retrospective study analyzed the association between pre-procedural NT-pro-BNP serum levels and the long-term outcome after a first-ever PVI in cryo-technique. Patients were followed by searching the hospital information system and conducting structured telephone interviews. Treatment failure was defined as any relapse of atrial fibrillation (AF) occurring 90 days after the index PVI at the earliest. Kaplan–Meier survival curves and Cox proportional hazards models were computed to assess the impact of NT-pro-BNP on AF recurrence. Following 374 patients over a median of 3.8 years (range: 0.25–9.4 years), baseline NT-pro-BNP was associated with the combined endpoint in univariate analysis (HR 1.04 per 100 pg/mL increase, 95% CI: 1.02–1.07, p < 0.001). Results were virtually unchanged in the multivariate model or if the data were log-transformed. Intraprocedural left atrial pressure correlated positively with log NT-pro-BNP. NT-pro-BNP was associated with AF relapse during a long-term follow-up after first-ever cryo-PVI in our cohort of patients with predominantly normal left ventricular function. This lab parameter is easy to obtain and has significant potential to guide treatment decisions. |
format | Online Article Text |
id | pubmed-9783297 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97832972022-12-24 NT-pro-BNP as a Predictor for Recurrence of Atrial Fibrillation after Primary Cryoballoon Pulmonary Vein Isolation Blessberger, Hermann Lambert, Thomas Nahler, Alexander Hrncic, Denis Hönig, Simon Maier, Julian Rechberger, Stefan Windhager, Armin Reiter, Christian Kellermair, Joerg Kammler, Juergen Wagner, Helga Steinwender, Clemens J Clin Med Article NT-pro-BNP is produced in the cardiac atria and ventricles in response to increased wall stress. It may be a marker of both AF disease progression and co-morbidities that affect success after pulmonary vein isolation (PVI). This single-center retrospective study analyzed the association between pre-procedural NT-pro-BNP serum levels and the long-term outcome after a first-ever PVI in cryo-technique. Patients were followed by searching the hospital information system and conducting structured telephone interviews. Treatment failure was defined as any relapse of atrial fibrillation (AF) occurring 90 days after the index PVI at the earliest. Kaplan–Meier survival curves and Cox proportional hazards models were computed to assess the impact of NT-pro-BNP on AF recurrence. Following 374 patients over a median of 3.8 years (range: 0.25–9.4 years), baseline NT-pro-BNP was associated with the combined endpoint in univariate analysis (HR 1.04 per 100 pg/mL increase, 95% CI: 1.02–1.07, p < 0.001). Results were virtually unchanged in the multivariate model or if the data were log-transformed. Intraprocedural left atrial pressure correlated positively with log NT-pro-BNP. NT-pro-BNP was associated with AF relapse during a long-term follow-up after first-ever cryo-PVI in our cohort of patients with predominantly normal left ventricular function. This lab parameter is easy to obtain and has significant potential to guide treatment decisions. MDPI 2022-12-14 /pmc/articles/PMC9783297/ /pubmed/36556020 http://dx.doi.org/10.3390/jcm11247400 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Blessberger, Hermann Lambert, Thomas Nahler, Alexander Hrncic, Denis Hönig, Simon Maier, Julian Rechberger, Stefan Windhager, Armin Reiter, Christian Kellermair, Joerg Kammler, Juergen Wagner, Helga Steinwender, Clemens NT-pro-BNP as a Predictor for Recurrence of Atrial Fibrillation after Primary Cryoballoon Pulmonary Vein Isolation |
title | NT-pro-BNP as a Predictor for Recurrence of Atrial Fibrillation after Primary Cryoballoon Pulmonary Vein Isolation |
title_full | NT-pro-BNP as a Predictor for Recurrence of Atrial Fibrillation after Primary Cryoballoon Pulmonary Vein Isolation |
title_fullStr | NT-pro-BNP as a Predictor for Recurrence of Atrial Fibrillation after Primary Cryoballoon Pulmonary Vein Isolation |
title_full_unstemmed | NT-pro-BNP as a Predictor for Recurrence of Atrial Fibrillation after Primary Cryoballoon Pulmonary Vein Isolation |
title_short | NT-pro-BNP as a Predictor for Recurrence of Atrial Fibrillation after Primary Cryoballoon Pulmonary Vein Isolation |
title_sort | nt-pro-bnp as a predictor for recurrence of atrial fibrillation after primary cryoballoon pulmonary vein isolation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783297/ https://www.ncbi.nlm.nih.gov/pubmed/36556020 http://dx.doi.org/10.3390/jcm11247400 |
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