Cargando…

Effect of Folic Acid Treatment for Patients with Traumatic Brain Injury (TBI)-Related Hospital Acquired Pneumonia (HAP): A Retrospective Cohort Study

Hospital Acquired Pneumonia (HAP) is one of the most common complications and late causes of death in TBI patients. Targeted prevention and treatment of HAP are of great significance for improving the prognosis of TBI patients. In the previous clinical observation, we found that folic acid treatment...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Hao, Geng, Xin, Liu, Chenan, Ballah, Augustine K., Li, Feixiang, Han, Tangrui, Gao, Shuai, Wang, Chunhong, Ji, Hongming, Nie, Xiaoqi, Cheng, Gang, Wang, Xiangyu, Cheng, Rui, Wang, Yonghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783303/
https://www.ncbi.nlm.nih.gov/pubmed/36556017
http://dx.doi.org/10.3390/jcm11247403
_version_ 1784857546207526912
author Wu, Hao
Geng, Xin
Liu, Chenan
Ballah, Augustine K.
Li, Feixiang
Han, Tangrui
Gao, Shuai
Wang, Chunhong
Ji, Hongming
Nie, Xiaoqi
Cheng, Gang
Wang, Xiangyu
Cheng, Rui
Wang, Yonghong
author_facet Wu, Hao
Geng, Xin
Liu, Chenan
Ballah, Augustine K.
Li, Feixiang
Han, Tangrui
Gao, Shuai
Wang, Chunhong
Ji, Hongming
Nie, Xiaoqi
Cheng, Gang
Wang, Xiangyu
Cheng, Rui
Wang, Yonghong
author_sort Wu, Hao
collection PubMed
description Hospital Acquired Pneumonia (HAP) is one of the most common complications and late causes of death in TBI patients. Targeted prevention and treatment of HAP are of great significance for improving the prognosis of TBI patients. In the previous clinical observation, we found that folic acid treatment for TBI patients has a good effect on preventing and treating HAP. We conducted this retrospective cohort study to demonstrate what we observed by selecting 293 TBI patients from two medical centers and analyzing their hospitalization data. The result showed that the incidence of HAP was significantly lower in TBI patients who received folic acid treatment (44.1% vs. 63.0%, p = 0.012). Multivariate logistic regression analysis showed that folic acid treatment was an independent protective factor for the occurrence of HAP in TBI patients (OR = 0.418, p = 0.031), especially in high-risk groups of HAP, such as the old (OR: 1.356 vs. 2.889), ICU (OR: 1.775 vs. 5.996) and severe TBI (OR: 0.975 vs. 5.424) patients. At the same time, cohort studies of HAP patients showed that folic acid also had a good effect on delaying the progression of HAP, such as reducing the chance of tracheotomy (26.1% vs. 50.8%, p = 0.041), and reduced the length of hospital stay (15 d vs. 19 d, p = 0.029) and ICU stay (5 d vs. 8 d, p = 0.046). Therefore, we believe that folic acid treatment in TBI patients has the potential for preventing and treating HAP, and it is worthy of further clinical research.
format Online
Article
Text
id pubmed-9783303
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97833032022-12-24 Effect of Folic Acid Treatment for Patients with Traumatic Brain Injury (TBI)-Related Hospital Acquired Pneumonia (HAP): A Retrospective Cohort Study Wu, Hao Geng, Xin Liu, Chenan Ballah, Augustine K. Li, Feixiang Han, Tangrui Gao, Shuai Wang, Chunhong Ji, Hongming Nie, Xiaoqi Cheng, Gang Wang, Xiangyu Cheng, Rui Wang, Yonghong J Clin Med Article Hospital Acquired Pneumonia (HAP) is one of the most common complications and late causes of death in TBI patients. Targeted prevention and treatment of HAP are of great significance for improving the prognosis of TBI patients. In the previous clinical observation, we found that folic acid treatment for TBI patients has a good effect on preventing and treating HAP. We conducted this retrospective cohort study to demonstrate what we observed by selecting 293 TBI patients from two medical centers and analyzing their hospitalization data. The result showed that the incidence of HAP was significantly lower in TBI patients who received folic acid treatment (44.1% vs. 63.0%, p = 0.012). Multivariate logistic regression analysis showed that folic acid treatment was an independent protective factor for the occurrence of HAP in TBI patients (OR = 0.418, p = 0.031), especially in high-risk groups of HAP, such as the old (OR: 1.356 vs. 2.889), ICU (OR: 1.775 vs. 5.996) and severe TBI (OR: 0.975 vs. 5.424) patients. At the same time, cohort studies of HAP patients showed that folic acid also had a good effect on delaying the progression of HAP, such as reducing the chance of tracheotomy (26.1% vs. 50.8%, p = 0.041), and reduced the length of hospital stay (15 d vs. 19 d, p = 0.029) and ICU stay (5 d vs. 8 d, p = 0.046). Therefore, we believe that folic acid treatment in TBI patients has the potential for preventing and treating HAP, and it is worthy of further clinical research. MDPI 2022-12-14 /pmc/articles/PMC9783303/ /pubmed/36556017 http://dx.doi.org/10.3390/jcm11247403 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Hao
Geng, Xin
Liu, Chenan
Ballah, Augustine K.
Li, Feixiang
Han, Tangrui
Gao, Shuai
Wang, Chunhong
Ji, Hongming
Nie, Xiaoqi
Cheng, Gang
Wang, Xiangyu
Cheng, Rui
Wang, Yonghong
Effect of Folic Acid Treatment for Patients with Traumatic Brain Injury (TBI)-Related Hospital Acquired Pneumonia (HAP): A Retrospective Cohort Study
title Effect of Folic Acid Treatment for Patients with Traumatic Brain Injury (TBI)-Related Hospital Acquired Pneumonia (HAP): A Retrospective Cohort Study
title_full Effect of Folic Acid Treatment for Patients with Traumatic Brain Injury (TBI)-Related Hospital Acquired Pneumonia (HAP): A Retrospective Cohort Study
title_fullStr Effect of Folic Acid Treatment for Patients with Traumatic Brain Injury (TBI)-Related Hospital Acquired Pneumonia (HAP): A Retrospective Cohort Study
title_full_unstemmed Effect of Folic Acid Treatment for Patients with Traumatic Brain Injury (TBI)-Related Hospital Acquired Pneumonia (HAP): A Retrospective Cohort Study
title_short Effect of Folic Acid Treatment for Patients with Traumatic Brain Injury (TBI)-Related Hospital Acquired Pneumonia (HAP): A Retrospective Cohort Study
title_sort effect of folic acid treatment for patients with traumatic brain injury (tbi)-related hospital acquired pneumonia (hap): a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783303/
https://www.ncbi.nlm.nih.gov/pubmed/36556017
http://dx.doi.org/10.3390/jcm11247403
work_keys_str_mv AT wuhao effectoffolicacidtreatmentforpatientswithtraumaticbraininjurytbirelatedhospitalacquiredpneumoniahaparetrospectivecohortstudy
AT gengxin effectoffolicacidtreatmentforpatientswithtraumaticbraininjurytbirelatedhospitalacquiredpneumoniahaparetrospectivecohortstudy
AT liuchenan effectoffolicacidtreatmentforpatientswithtraumaticbraininjurytbirelatedhospitalacquiredpneumoniahaparetrospectivecohortstudy
AT ballahaugustinek effectoffolicacidtreatmentforpatientswithtraumaticbraininjurytbirelatedhospitalacquiredpneumoniahaparetrospectivecohortstudy
AT lifeixiang effectoffolicacidtreatmentforpatientswithtraumaticbraininjurytbirelatedhospitalacquiredpneumoniahaparetrospectivecohortstudy
AT hantangrui effectoffolicacidtreatmentforpatientswithtraumaticbraininjurytbirelatedhospitalacquiredpneumoniahaparetrospectivecohortstudy
AT gaoshuai effectoffolicacidtreatmentforpatientswithtraumaticbraininjurytbirelatedhospitalacquiredpneumoniahaparetrospectivecohortstudy
AT wangchunhong effectoffolicacidtreatmentforpatientswithtraumaticbraininjurytbirelatedhospitalacquiredpneumoniahaparetrospectivecohortstudy
AT jihongming effectoffolicacidtreatmentforpatientswithtraumaticbraininjurytbirelatedhospitalacquiredpneumoniahaparetrospectivecohortstudy
AT niexiaoqi effectoffolicacidtreatmentforpatientswithtraumaticbraininjurytbirelatedhospitalacquiredpneumoniahaparetrospectivecohortstudy
AT chenggang effectoffolicacidtreatmentforpatientswithtraumaticbraininjurytbirelatedhospitalacquiredpneumoniahaparetrospectivecohortstudy
AT wangxiangyu effectoffolicacidtreatmentforpatientswithtraumaticbraininjurytbirelatedhospitalacquiredpneumoniahaparetrospectivecohortstudy
AT chengrui effectoffolicacidtreatmentforpatientswithtraumaticbraininjurytbirelatedhospitalacquiredpneumoniahaparetrospectivecohortstudy
AT wangyonghong effectoffolicacidtreatmentforpatientswithtraumaticbraininjurytbirelatedhospitalacquiredpneumoniahaparetrospectivecohortstudy