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Differences in functional connectivity distribution after transcranial direct‐current stimulation: A connectivity density point of view
In this manuscript, we consider the problem of relating functional connectivity measurements viewed as statistical distributions to outcomes. We demonstrate the utility of using the distribution of connectivity on a study of resting‐state functional magnetic resonance imaging association with an int...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783448/ https://www.ncbi.nlm.nih.gov/pubmed/36371779 http://dx.doi.org/10.1002/hbm.26112 |
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author | Tang, Bohao Zhao, Yi Venkataraman, Archana Tsapkini, Kyrana Lindquist, Martin A. Pekar, James Caffo, Brian |
author_facet | Tang, Bohao Zhao, Yi Venkataraman, Archana Tsapkini, Kyrana Lindquist, Martin A. Pekar, James Caffo, Brian |
author_sort | Tang, Bohao |
collection | PubMed |
description | In this manuscript, we consider the problem of relating functional connectivity measurements viewed as statistical distributions to outcomes. We demonstrate the utility of using the distribution of connectivity on a study of resting‐state functional magnetic resonance imaging association with an intervention. The method uses the estimated density of connectivity between nodes of interest as a functional covariate. Moreover, we demonstrate the utility of the procedure in an instance where connectivity is naturally considered an outcome by reversing the predictor/response relationship using case/control methodology. The method utilizes the density quantile, the density evaluated at empirical quantiles, instead of the empirical density directly. This improved the performance of the method by highlighting tail behavior, though we emphasize that by being flexible and non‐parametric, the technique can detect effects related to the central portion of the density. To demonstrate the method in an application, we consider 47 primary progressive aphasia patients with various levels of language abilities. These patients were randomly assigned to two treatment arms, transcranial direct‐current stimulation and language therapy versus sham (language therapy only), in a clinical trial. We use the method to analyze the effect of direct stimulation on functional connectivity. As such, we estimate the density of correlations among the regions of interest and study the difference in the density post‐intervention between treatment arms. We discover that it is the tail of the density, rather than the mean or lower order moments of the distribution, that demonstrates a significant impact in the classification. The new approach has several benefits. Among them, it drastically reduces the number of multiple comparisons compared with edge‐wise analysis. In addition, it allows for the investigation of the impact of functional connectivity on the outcomes where the connectivity is not geometrically localized. |
format | Online Article Text |
id | pubmed-9783448 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97834482022-12-27 Differences in functional connectivity distribution after transcranial direct‐current stimulation: A connectivity density point of view Tang, Bohao Zhao, Yi Venkataraman, Archana Tsapkini, Kyrana Lindquist, Martin A. Pekar, James Caffo, Brian Hum Brain Mapp Research Articles In this manuscript, we consider the problem of relating functional connectivity measurements viewed as statistical distributions to outcomes. We demonstrate the utility of using the distribution of connectivity on a study of resting‐state functional magnetic resonance imaging association with an intervention. The method uses the estimated density of connectivity between nodes of interest as a functional covariate. Moreover, we demonstrate the utility of the procedure in an instance where connectivity is naturally considered an outcome by reversing the predictor/response relationship using case/control methodology. The method utilizes the density quantile, the density evaluated at empirical quantiles, instead of the empirical density directly. This improved the performance of the method by highlighting tail behavior, though we emphasize that by being flexible and non‐parametric, the technique can detect effects related to the central portion of the density. To demonstrate the method in an application, we consider 47 primary progressive aphasia patients with various levels of language abilities. These patients were randomly assigned to two treatment arms, transcranial direct‐current stimulation and language therapy versus sham (language therapy only), in a clinical trial. We use the method to analyze the effect of direct stimulation on functional connectivity. As such, we estimate the density of correlations among the regions of interest and study the difference in the density post‐intervention between treatment arms. We discover that it is the tail of the density, rather than the mean or lower order moments of the distribution, that demonstrates a significant impact in the classification. The new approach has several benefits. Among them, it drastically reduces the number of multiple comparisons compared with edge‐wise analysis. In addition, it allows for the investigation of the impact of functional connectivity on the outcomes where the connectivity is not geometrically localized. John Wiley & Sons, Inc. 2022-11-13 /pmc/articles/PMC9783448/ /pubmed/36371779 http://dx.doi.org/10.1002/hbm.26112 Text en © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Tang, Bohao Zhao, Yi Venkataraman, Archana Tsapkini, Kyrana Lindquist, Martin A. Pekar, James Caffo, Brian Differences in functional connectivity distribution after transcranial direct‐current stimulation: A connectivity density point of view |
title | Differences in functional connectivity distribution after transcranial direct‐current stimulation: A connectivity density point of view |
title_full | Differences in functional connectivity distribution after transcranial direct‐current stimulation: A connectivity density point of view |
title_fullStr | Differences in functional connectivity distribution after transcranial direct‐current stimulation: A connectivity density point of view |
title_full_unstemmed | Differences in functional connectivity distribution after transcranial direct‐current stimulation: A connectivity density point of view |
title_short | Differences in functional connectivity distribution after transcranial direct‐current stimulation: A connectivity density point of view |
title_sort | differences in functional connectivity distribution after transcranial direct‐current stimulation: a connectivity density point of view |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783448/ https://www.ncbi.nlm.nih.gov/pubmed/36371779 http://dx.doi.org/10.1002/hbm.26112 |
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