TREM2 dependent and independent functions of microglia in Alzheimer’s disease

Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer’s disease (AD). In this review, we aim to summarize the genetic and functional discoveries that have advanced our understanding of microglia reactivity to AD pathology. Given the heigh...

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Autores principales: Hou, Jinchao, Chen, Yun, Grajales-Reyes, Gary, Colonna, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783481/
https://www.ncbi.nlm.nih.gov/pubmed/36564824
http://dx.doi.org/10.1186/s13024-022-00588-y
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author Hou, Jinchao
Chen, Yun
Grajales-Reyes, Gary
Colonna, Marco
author_facet Hou, Jinchao
Chen, Yun
Grajales-Reyes, Gary
Colonna, Marco
author_sort Hou, Jinchao
collection PubMed
description Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer’s disease (AD). In this review, we aim to summarize the genetic and functional discoveries that have advanced our understanding of microglia reactivity to AD pathology. Given the heightened AD risk posed by rare variants of the microglial triggering receptor expressed on myeloid cells 2 (TREM2), we will focus on the studies addressing the impact of this receptor on microglia responses to amyloid plaques, tauopathy and demyelination pathologies in mouse and human. Finally, we will discuss the implications of recent discoveries on microglia and TREM2 biology on potential therapeutic strategies for AD.
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spelling pubmed-97834812022-12-24 TREM2 dependent and independent functions of microglia in Alzheimer’s disease Hou, Jinchao Chen, Yun Grajales-Reyes, Gary Colonna, Marco Mol Neurodegener Review Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer’s disease (AD). In this review, we aim to summarize the genetic and functional discoveries that have advanced our understanding of microglia reactivity to AD pathology. Given the heightened AD risk posed by rare variants of the microglial triggering receptor expressed on myeloid cells 2 (TREM2), we will focus on the studies addressing the impact of this receptor on microglia responses to amyloid plaques, tauopathy and demyelination pathologies in mouse and human. Finally, we will discuss the implications of recent discoveries on microglia and TREM2 biology on potential therapeutic strategies for AD. BioMed Central 2022-12-23 /pmc/articles/PMC9783481/ /pubmed/36564824 http://dx.doi.org/10.1186/s13024-022-00588-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Hou, Jinchao
Chen, Yun
Grajales-Reyes, Gary
Colonna, Marco
TREM2 dependent and independent functions of microglia in Alzheimer’s disease
title TREM2 dependent and independent functions of microglia in Alzheimer’s disease
title_full TREM2 dependent and independent functions of microglia in Alzheimer’s disease
title_fullStr TREM2 dependent and independent functions of microglia in Alzheimer’s disease
title_full_unstemmed TREM2 dependent and independent functions of microglia in Alzheimer’s disease
title_short TREM2 dependent and independent functions of microglia in Alzheimer’s disease
title_sort trem2 dependent and independent functions of microglia in alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783481/
https://www.ncbi.nlm.nih.gov/pubmed/36564824
http://dx.doi.org/10.1186/s13024-022-00588-y
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