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DeepParcellation: A novel deep learning method for robust brain magnetic resonance imaging parcellation in older East Asians

Accurate parcellation of cortical regions is crucial for distinguishing morphometric changes in aged brains, particularly in degenerative brain diseases. Normal aging and neurodegeneration precipitate brain structural changes, leading to distinct tissue contrast and shape in people aged >60 years...

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Autores principales: Lim, Eun-Cheon, Choi, Uk-Su, Choi, Kyu Yeong, Lee, Jang Jae, Sung, Yul-Wan, Ogawa, Seiji, Kim, Byeong Chae, Lee, Kun Ho, Gim, Jungsoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783623/
https://www.ncbi.nlm.nih.gov/pubmed/36570529
http://dx.doi.org/10.3389/fnagi.2022.1027857
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author Lim, Eun-Cheon
Choi, Uk-Su
Choi, Kyu Yeong
Lee, Jang Jae
Sung, Yul-Wan
Ogawa, Seiji
Kim, Byeong Chae
Lee, Kun Ho
Gim, Jungsoo
author_facet Lim, Eun-Cheon
Choi, Uk-Su
Choi, Kyu Yeong
Lee, Jang Jae
Sung, Yul-Wan
Ogawa, Seiji
Kim, Byeong Chae
Lee, Kun Ho
Gim, Jungsoo
author_sort Lim, Eun-Cheon
collection PubMed
description Accurate parcellation of cortical regions is crucial for distinguishing morphometric changes in aged brains, particularly in degenerative brain diseases. Normal aging and neurodegeneration precipitate brain structural changes, leading to distinct tissue contrast and shape in people aged >60 years. Manual parcellation by trained radiologists can yield a highly accurate outline of the brain; however, analyzing large datasets is laborious and expensive. Alternatively, newly-developed computational models can quickly and accurately conduct brain parcellation, although thus far only for the brains of Caucasian individuals. To develop a computational model for the brain parcellation of older East Asians, we trained magnetic resonance images of dimensions 256 × 256 × 256 on 5,035 brains of older East Asians (Gwangju Alzheimer’s and Related Dementia) and 2,535 brains of Caucasians. The novel N-way strategy combining three memory reduction techniques inception blocks, dilated convolutions, and attention gates was adopted for our model to overcome the intrinsic memory requirement problem. Our method proved to be compatible with the commonly used parcellation model for Caucasians and showed higher similarity and robust reliability in older aged and East Asian groups. In addition, several brain regions showing the superiority of the parcellation suggest that DeepParcellation has a great potential for applications in neurodegenerative diseases such as Alzheimer’s disease.
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spelling pubmed-97836232022-12-24 DeepParcellation: A novel deep learning method for robust brain magnetic resonance imaging parcellation in older East Asians Lim, Eun-Cheon Choi, Uk-Su Choi, Kyu Yeong Lee, Jang Jae Sung, Yul-Wan Ogawa, Seiji Kim, Byeong Chae Lee, Kun Ho Gim, Jungsoo Front Aging Neurosci Aging Neuroscience Accurate parcellation of cortical regions is crucial for distinguishing morphometric changes in aged brains, particularly in degenerative brain diseases. Normal aging and neurodegeneration precipitate brain structural changes, leading to distinct tissue contrast and shape in people aged >60 years. Manual parcellation by trained radiologists can yield a highly accurate outline of the brain; however, analyzing large datasets is laborious and expensive. Alternatively, newly-developed computational models can quickly and accurately conduct brain parcellation, although thus far only for the brains of Caucasian individuals. To develop a computational model for the brain parcellation of older East Asians, we trained magnetic resonance images of dimensions 256 × 256 × 256 on 5,035 brains of older East Asians (Gwangju Alzheimer’s and Related Dementia) and 2,535 brains of Caucasians. The novel N-way strategy combining three memory reduction techniques inception blocks, dilated convolutions, and attention gates was adopted for our model to overcome the intrinsic memory requirement problem. Our method proved to be compatible with the commonly used parcellation model for Caucasians and showed higher similarity and robust reliability in older aged and East Asian groups. In addition, several brain regions showing the superiority of the parcellation suggest that DeepParcellation has a great potential for applications in neurodegenerative diseases such as Alzheimer’s disease. Frontiers Media S.A. 2022-12-09 /pmc/articles/PMC9783623/ /pubmed/36570529 http://dx.doi.org/10.3389/fnagi.2022.1027857 Text en Copyright © 2022 Lim, Choi, Choi, Lee, Sung, Ogawa, Kim, Lee and Gim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Lim, Eun-Cheon
Choi, Uk-Su
Choi, Kyu Yeong
Lee, Jang Jae
Sung, Yul-Wan
Ogawa, Seiji
Kim, Byeong Chae
Lee, Kun Ho
Gim, Jungsoo
DeepParcellation: A novel deep learning method for robust brain magnetic resonance imaging parcellation in older East Asians
title DeepParcellation: A novel deep learning method for robust brain magnetic resonance imaging parcellation in older East Asians
title_full DeepParcellation: A novel deep learning method for robust brain magnetic resonance imaging parcellation in older East Asians
title_fullStr DeepParcellation: A novel deep learning method for robust brain magnetic resonance imaging parcellation in older East Asians
title_full_unstemmed DeepParcellation: A novel deep learning method for robust brain magnetic resonance imaging parcellation in older East Asians
title_short DeepParcellation: A novel deep learning method for robust brain magnetic resonance imaging parcellation in older East Asians
title_sort deepparcellation: a novel deep learning method for robust brain magnetic resonance imaging parcellation in older east asians
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783623/
https://www.ncbi.nlm.nih.gov/pubmed/36570529
http://dx.doi.org/10.3389/fnagi.2022.1027857
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