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Eosinopenia as Predictor of Poor Outcome in Hospitalized COVID-19 Adult Patients from Waves 1 and 2 of 2020 Pandemic

During SARS-CoV-2 infection, eosinopenia may reflect a hyperactive immune response. In this study of hospitalized COVID-19 patients, we aimed to better understand the prognostic value of severe eosinopenia (absolute eosinophil count = 0 G/L) and decipher its underlying mechanisms. We retrospectively...

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Autores principales: Cauchois, Raphael, Pietri, Lea, Dalmas, Jean-Baptiste, Koubi, Marie, Capron, Thibaut, Cassir, Nadim, Potere, Nicola, Polidoro, Ildo, Jean, Rodolphe, Jarrot, Pierre-André, Andre, Baptiste, Veit, Veronique, Carvelli, Julien, Pauly, Vanessa, Chanez, Pascal, Papazian, Laurent, Kaplanski, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783665/
https://www.ncbi.nlm.nih.gov/pubmed/36557676
http://dx.doi.org/10.3390/microorganisms10122423
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author Cauchois, Raphael
Pietri, Lea
Dalmas, Jean-Baptiste
Koubi, Marie
Capron, Thibaut
Cassir, Nadim
Potere, Nicola
Polidoro, Ildo
Jean, Rodolphe
Jarrot, Pierre-André
Andre, Baptiste
Veit, Veronique
Carvelli, Julien
Pauly, Vanessa
Chanez, Pascal
Papazian, Laurent
Kaplanski, Gilles
author_facet Cauchois, Raphael
Pietri, Lea
Dalmas, Jean-Baptiste
Koubi, Marie
Capron, Thibaut
Cassir, Nadim
Potere, Nicola
Polidoro, Ildo
Jean, Rodolphe
Jarrot, Pierre-André
Andre, Baptiste
Veit, Veronique
Carvelli, Julien
Pauly, Vanessa
Chanez, Pascal
Papazian, Laurent
Kaplanski, Gilles
author_sort Cauchois, Raphael
collection PubMed
description During SARS-CoV-2 infection, eosinopenia may reflect a hyperactive immune response. In this study of hospitalized COVID-19 patients, we aimed to better understand the prognostic value of severe eosinopenia (absolute eosinophil count = 0 G/L) and decipher its underlying mechanisms. We retrospectively analyzed the records of COVID-19 patients hospitalized from March to June 2020 in three university hospitals in Marseille, France. We assessed the association between severe eosinopenia and a composite poor outcome in these patients, including the need for oxygen supplementation at >6 L/min, ICU admission, and in-hospital death. Among the 551 COVID-19 patients included in this study, severe eosinopenia was found in 228 (51%) of them on admission to hospital and was associated with a composite poor outcome using multivariate analysis (OR = 2.58; CI95 [1.77–3.75]; p < 0.0001). We found a significant association between the presence of severe eosinopenia on admission and the elevation in C-reactive protein, ferritin, IP-10, and suPAR. The histological findings in a series of 37 autopsies from patients who died from severe COVID-19 and presented with severe eosinopenia showed no pulmonary eosinophil trapping. Severe eosinopenia can be a reliable biomarker associated with a composite poor outcome in hospitalized COVID-19 adult patients. It may reflect the magnitude of immune hyperactivation during severe-to-critical COVID-19.
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spelling pubmed-97836652022-12-24 Eosinopenia as Predictor of Poor Outcome in Hospitalized COVID-19 Adult Patients from Waves 1 and 2 of 2020 Pandemic Cauchois, Raphael Pietri, Lea Dalmas, Jean-Baptiste Koubi, Marie Capron, Thibaut Cassir, Nadim Potere, Nicola Polidoro, Ildo Jean, Rodolphe Jarrot, Pierre-André Andre, Baptiste Veit, Veronique Carvelli, Julien Pauly, Vanessa Chanez, Pascal Papazian, Laurent Kaplanski, Gilles Microorganisms Article During SARS-CoV-2 infection, eosinopenia may reflect a hyperactive immune response. In this study of hospitalized COVID-19 patients, we aimed to better understand the prognostic value of severe eosinopenia (absolute eosinophil count = 0 G/L) and decipher its underlying mechanisms. We retrospectively analyzed the records of COVID-19 patients hospitalized from March to June 2020 in three university hospitals in Marseille, France. We assessed the association between severe eosinopenia and a composite poor outcome in these patients, including the need for oxygen supplementation at >6 L/min, ICU admission, and in-hospital death. Among the 551 COVID-19 patients included in this study, severe eosinopenia was found in 228 (51%) of them on admission to hospital and was associated with a composite poor outcome using multivariate analysis (OR = 2.58; CI95 [1.77–3.75]; p < 0.0001). We found a significant association between the presence of severe eosinopenia on admission and the elevation in C-reactive protein, ferritin, IP-10, and suPAR. The histological findings in a series of 37 autopsies from patients who died from severe COVID-19 and presented with severe eosinopenia showed no pulmonary eosinophil trapping. Severe eosinopenia can be a reliable biomarker associated with a composite poor outcome in hospitalized COVID-19 adult patients. It may reflect the magnitude of immune hyperactivation during severe-to-critical COVID-19. MDPI 2022-12-07 /pmc/articles/PMC9783665/ /pubmed/36557676 http://dx.doi.org/10.3390/microorganisms10122423 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cauchois, Raphael
Pietri, Lea
Dalmas, Jean-Baptiste
Koubi, Marie
Capron, Thibaut
Cassir, Nadim
Potere, Nicola
Polidoro, Ildo
Jean, Rodolphe
Jarrot, Pierre-André
Andre, Baptiste
Veit, Veronique
Carvelli, Julien
Pauly, Vanessa
Chanez, Pascal
Papazian, Laurent
Kaplanski, Gilles
Eosinopenia as Predictor of Poor Outcome in Hospitalized COVID-19 Adult Patients from Waves 1 and 2 of 2020 Pandemic
title Eosinopenia as Predictor of Poor Outcome in Hospitalized COVID-19 Adult Patients from Waves 1 and 2 of 2020 Pandemic
title_full Eosinopenia as Predictor of Poor Outcome in Hospitalized COVID-19 Adult Patients from Waves 1 and 2 of 2020 Pandemic
title_fullStr Eosinopenia as Predictor of Poor Outcome in Hospitalized COVID-19 Adult Patients from Waves 1 and 2 of 2020 Pandemic
title_full_unstemmed Eosinopenia as Predictor of Poor Outcome in Hospitalized COVID-19 Adult Patients from Waves 1 and 2 of 2020 Pandemic
title_short Eosinopenia as Predictor of Poor Outcome in Hospitalized COVID-19 Adult Patients from Waves 1 and 2 of 2020 Pandemic
title_sort eosinopenia as predictor of poor outcome in hospitalized covid-19 adult patients from waves 1 and 2 of 2020 pandemic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783665/
https://www.ncbi.nlm.nih.gov/pubmed/36557676
http://dx.doi.org/10.3390/microorganisms10122423
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