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A neuroendocrine tumor within an anterior mediastinal mature teratoma: a case report
BACKGROUND: Mature teratomas are benign germ cell tumors. On rare occasions, they have been associated with somatic malignancies and are termed rare germ cell tumors with a somatic-type malignancy (GCTSM). Mature teratomas commonly comprise adenocarcinomas; only seven previous cases of mature terato...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783718/ https://www.ncbi.nlm.nih.gov/pubmed/36550490 http://dx.doi.org/10.1186/s13019-022-02091-3 |
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author | Sato, Daisuke Izu, Asami Sakakibara, Masashi Hayashi, Sohei Kawachi, Riken Shimamura, Mie Masuda, Shinobu Sakurai, Hiroyuki |
author_facet | Sato, Daisuke Izu, Asami Sakakibara, Masashi Hayashi, Sohei Kawachi, Riken Shimamura, Mie Masuda, Shinobu Sakurai, Hiroyuki |
author_sort | Sato, Daisuke |
collection | PubMed |
description | BACKGROUND: Mature teratomas are benign germ cell tumors. On rare occasions, they have been associated with somatic malignancies and are termed rare germ cell tumors with a somatic-type malignancy (GCTSM). Mature teratomas commonly comprise adenocarcinomas; only seven previous cases of mature teratomas with neuroendocrine tumors have been reported to date. Here, we report a patient with a neuroendocrine tumor whithin a mature teratoma. CASE PRESENTATION: A 26-year-old man visited our department complaining of chest tightness. Contrast-enhanced computed tomography (CT) scans showed a strongly enhanced lesion within a 10-cm encapsulated cystic lesion in the anterior mediastinum. Positron emission tomography (PET) scans showed no areas of significant (18)F-fluorodeoxyglucose ((18)F-FDG) accumulation. He underwent complete tumor resection via the transsternal approach. Histopathological examination of the specimen indicated a neuroendocrine tumor contained within a mature teratoma. CONCLUSIONS: In this case, a neuroendocrine tumor was contained within a mature teratoma. Our patient had no specific symptoms and his serum markers were within the normal range. Although PET is beneficial for diagnosing other GCTSM, it is not useful in detecting a neuroendocrine tumor. Therefore, the preoperative diagnosis of neuroendocrine tumors contained within mature teratomas remains challenging. However, GCTSM should be suspected in patients exhibiting CT findings of a mediastinal tumor, measuring ≥ 6 cm, in addition to characteristic GCTSM findings. Moreover, surgery should be performed carefully in such cases. |
format | Online Article Text |
id | pubmed-9783718 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-97837182022-12-24 A neuroendocrine tumor within an anterior mediastinal mature teratoma: a case report Sato, Daisuke Izu, Asami Sakakibara, Masashi Hayashi, Sohei Kawachi, Riken Shimamura, Mie Masuda, Shinobu Sakurai, Hiroyuki J Cardiothorac Surg Case Report BACKGROUND: Mature teratomas are benign germ cell tumors. On rare occasions, they have been associated with somatic malignancies and are termed rare germ cell tumors with a somatic-type malignancy (GCTSM). Mature teratomas commonly comprise adenocarcinomas; only seven previous cases of mature teratomas with neuroendocrine tumors have been reported to date. Here, we report a patient with a neuroendocrine tumor whithin a mature teratoma. CASE PRESENTATION: A 26-year-old man visited our department complaining of chest tightness. Contrast-enhanced computed tomography (CT) scans showed a strongly enhanced lesion within a 10-cm encapsulated cystic lesion in the anterior mediastinum. Positron emission tomography (PET) scans showed no areas of significant (18)F-fluorodeoxyglucose ((18)F-FDG) accumulation. He underwent complete tumor resection via the transsternal approach. Histopathological examination of the specimen indicated a neuroendocrine tumor contained within a mature teratoma. CONCLUSIONS: In this case, a neuroendocrine tumor was contained within a mature teratoma. Our patient had no specific symptoms and his serum markers were within the normal range. Although PET is beneficial for diagnosing other GCTSM, it is not useful in detecting a neuroendocrine tumor. Therefore, the preoperative diagnosis of neuroendocrine tumors contained within mature teratomas remains challenging. However, GCTSM should be suspected in patients exhibiting CT findings of a mediastinal tumor, measuring ≥ 6 cm, in addition to characteristic GCTSM findings. Moreover, surgery should be performed carefully in such cases. BioMed Central 2022-12-22 /pmc/articles/PMC9783718/ /pubmed/36550490 http://dx.doi.org/10.1186/s13019-022-02091-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Sato, Daisuke Izu, Asami Sakakibara, Masashi Hayashi, Sohei Kawachi, Riken Shimamura, Mie Masuda, Shinobu Sakurai, Hiroyuki A neuroendocrine tumor within an anterior mediastinal mature teratoma: a case report |
title | A neuroendocrine tumor within an anterior mediastinal mature teratoma: a case report |
title_full | A neuroendocrine tumor within an anterior mediastinal mature teratoma: a case report |
title_fullStr | A neuroendocrine tumor within an anterior mediastinal mature teratoma: a case report |
title_full_unstemmed | A neuroendocrine tumor within an anterior mediastinal mature teratoma: a case report |
title_short | A neuroendocrine tumor within an anterior mediastinal mature teratoma: a case report |
title_sort | neuroendocrine tumor within an anterior mediastinal mature teratoma: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783718/ https://www.ncbi.nlm.nih.gov/pubmed/36550490 http://dx.doi.org/10.1186/s13019-022-02091-3 |
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